Effects of Rhubarb on Intestinal Flora and Toll-Like Receptors of Intestinal Mucosa in Rats With Severe Acute Pancreatitis

Yao, Ping; Cui, Min; Li, Yan; Deng, Yiyun; Wu, Hao

doi:10.1097/mpa.0000000000000339

Cited by 26 publications

(17 citation statements)

References 26 publications

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“…Currently the intestinal floras that have been detected are Bacteroides , Firmicutes, Fusobacterium , Actinomycetes, Verrucomicrobia, Proteobacteria, Spirochaetes, Cyanobacteria, VadinBE97 and Methanobrevibacter ( 4 ). The intestinal floras are maintained in a relatively balanced state in the human body under normal conditions, which can regulate and nurture the intestines, influence the immune system of the body, effectively prevent the invasion of pathogenic bacteria and have a close association with hypertension ( 5 ). Bacteroides thetaiotaomicron is one of the largest microflora in the intestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Correlation analysis of intestinal flora with hypertension

Liu¹,

et al. 2018

Exp Ther Med

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Relationship between intestinal flora content and hypertension was investigated. Ninety-four patients with hypertension who were admitted and treated in No. 215 Hospital of Shaanxi Nuclear Industry from May 2016 to April 2017 were selected as the observation group; and 94 healthy people from the physical examination center of No. 215 Hospital of Shaanxi Nuclear Industry in the same time period were selected as the control group. The systolic (SBP) and diastolic blood pressure (DBP) of all the participants were measured. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the quantities of Eubacterium rectale, Bacteroides thetaiotaomicron and Bifidobacterium in the intestines, and correlation analyses were performed. The SBP, DBP and content of Eubacterium rectale in the observation group were significantly higher than those in the control group, while the contents of Bacteroides thetaiotaomicron and Bifidobacterium were obviously lower than those in the control group (P<0.05). Pearson's correlation analysis showed that Eubacterium rectale was positively correlated with SBP and DBP, while Bacteroides thetaiotaomicron and Bifidobacterium had a negative correlation with SBP and DBP (P<0.05). The results showed that the quantities of Bifidobacterium and Bacteroides thetaiotaomicron are decreased while the number of Eubacterium rectale is increased in the intestines of patients with hypertension. Moreover, the content of intestinal flora has a significant correlation with hypertension.

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Section: Introductionmentioning

confidence: 99%

Correlation analysis of intestinal flora with hypertension

Liu¹,

et al. 2018

Exp Ther Med

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“…As expected, co‐administration of rhubarb with EEN significantly improved the therapeutic outcomes as depicted by the improved gastrointestinal function and suppressed systemic inflammation and modulation of SAP‐associated damages of liver and kidney function in patients (Wan et al , ). In support of these clinical findings, another group found out that rhubarb improves the integrity of microbial flora during SAP and may play an important role in maintaining the intestinal mucosal barrier by controlling intestinal flora and its antiinflammatory effect on intestinal tissue (Yao et al , ,b). Rhein is the active constituent behind the potential antipancreatitic activity of rhubarb.…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 84%

“…In another report, P‐selectin was reported to be involved in the protection by pharmacological intervention of emodin from MODS (liver, lungs and intestines) associated with SAP (Wan et al , ). Emodin exhibits its antiinflammatory property by following mechanisms: (i) it blocks the NF‐κB activity, in turn decreasing levels of TNF‐α, IL‐6 and IL‐1β expression in serum; (ii) it may overcome calcium overload and endoplasmic reticulum stress levels which are elevated during pancreatitis; (iii) it blocks TGF‐β 1 activation which is a critical factor for the progress to pancreatic fibrosis; and (iv) it increases expression of ICAM‐3 (Lou et al , ; Wu et al , ; Ni et al , ; Yao et al , ,b). Despite a large number of other supporting reports with emodin in SAP, the molecule has not been approved clinically, and a critical control needs to be maintained behind the rationale for studying the pharmacological intervention in a single disease as many reports with emodin in SAP lack proper rationale.…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 99%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Studies have shown that translocation of bacteria through the intestinal wall represents the major cause of pancreatic and peripancreatic infection and sepsis, as well as systemic inflammatory response syndrome and multiple organ dysfunction, so it can't be overemphasized the importance of maintaining intestinal mucosal barrier integrity and preventing translocation of bacteria and endotoxins. [4,5,6,7,8] Epithelial cells and intercellular adhesion are the fundamental components of the intestinal mucosal barrier, and the latter includes tight junction, adhesion junction, gap junction, etc. The junction proteins between epithelial cells mainly include occludin, claudin, ZO-1, and so on, whereas occludin is one of the major functional components of tight junction between cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of NF-κB and Occludin in Intestinal Mucosal Barrier During Severe Acute Pancreatitis and Its Clinical Significance

Zhu¹,

Yang²,

Pan³

et al. 2017

AJIM

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Abstract:Objective to investigate the expression of NF-κB and occludin in intestinal mucosal barrier during severe acute pancreatitis (SAP) and its clinical significance. Method Twenty-four Wistar rats were randomly divided into a normal control group, an SAP group, and a PDTC group. The rats were sacrificed at 24h after modeling, and general appearance of the abdominal cavity, pathological changes of the intestinal mucosa, changes in intestinal mucosal permeability were observed, serum inflammatory factor IL-1 was measured, and expression of tight junction protein occludin in the intestinal epithelial cells were determined by immunohistochemistry. Results Rats of the SAP group showed obvious inflammatory reaction in the abdominal cavity, manifested by enlargement of intestinal tract, intestinal edema, and increased permeability of intestinal barrier, whereas NF-κB inhibitor alleviated intestinal damage and intestinal mucosa edema, upregulated intestinal epithelial tight junction protein occludin, decreased intestinal permeability, and lowered the level of inflammatory factors. Conclusion Impairment of intestinal barrier function during SAP may be associated with increased NF-κB and decreased intestinal tight junction protein occludin; inhibiting NF-kB may alleviate intestinal mucosal barrier dysfunction during SAP.

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Effects of Rhubarb on Intestinal Flora and Toll-Like Receptors of Intestinal Mucosa in Rats With Severe Acute Pancreatitis

Abstract: Rhubarb might maintain the intestinal mucosal barrier through regulating intestinal flora and inhibiting intestinal inflammatory response in rats with SAP.

Cited by 26 publications

References 26 publications

Correlation analysis of intestinal flora with hypertension

Correlation analysis of intestinal flora with hypertension

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

Expression of NF-κB and Occludin in Intestinal Mucosal Barrier During Severe Acute Pancreatitis and Its Clinical Significance

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