Effects of Rhodiola rosea extract on passive avoidance tests in rats

Abstract

<jats:title>Abstract</jats:title><jats:p>The purpose was to evaluate the effects of extract of Rhodiola rosea on learning and memory processes on rats. The two series of experiments were carried out — on naïve rats and on rats with scopolamine-impaired memory. The passive avoidance tests were performed — step-down and step-through. The latency of reactions in seconds was observed in both tests. Naïve rats treated with the extract in showed the prolongation of latency of reaction of both step-down and step-through passive avoidances compared to the controls. Rats with scopolamine-impaired memory showed shorter latency of reaction in both passive avoidance tests compared to the controls. Rats treated with the extract of Rh. Rosea with scopolamine-impaired memory prolonged the latency in both passive avoidance tests compared to scopolamine group. It was found that the extract of Rh. Rosea improved performance during learning session, short and long memory retrieval tests in naïve rats. Scopolamine impaired the learning and memory retrieval of rats, but Rh. Rosea pretreatment improved performance and turned off the deterioration effect of scopolamine on these brain functions probably by non-specific mechanisms on cholinergic neurons. The studied plant extract can be a candidate for treatment of dementia and other memory disturbances.</jats:p>

Anti-Amnesic Effect of Curculigo orchioides Plant Extract and Its Function on Acetylcholinesterase Enzyme

“…There is some connection in the AChE inhibition and memory improvement. Because the performance of a working memory task in a mice is significantly more sensitive to disruption of cholinergic mechanisms by AChE, in the hippocampus, than performance of reference memory task [31]. As the plant extract inhibit the AChE, so it possesses some ability to improve memory function of a mice.…”

Salidroside Protects Dopaminergic Neurons by Preserving Complex I Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway

“…Rhodiola rosea L. has been used for centuries in traditional medicinal practices in Asia, Scandinavia, and Eastern Europe to stimulate nerves, enhance physical and mental performance, improve resistance to high-altitude sickness, and treat fatigue, psychological stress, and depression [12, 13]. Salidroside (Sal), an active component extracted from Rhodiola rosea L., possesses multiple pharmacological properties, including antioxidant, antiaging, and antifatigue [12].…”