Beneficial effect of commercial Rhodiola extract in rats with scopolamine-induced memory impairment on active avoidance

Vasileva, Liliya V.; Getova, D.; Doncheva, N.; Marchev, Andrey S.; Georgiev, Milen I.

doi:10.1016/j.jep.2016.10.011

Cited by 22 publications

(27 citation statements)

References 22 publications

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“…Cognitive impairment following SCO treatment in rodents has been well established by various behavioral tasks used to assess learning and memory, and rodent models of SCO-induced amnesia have been widely used to investigate the efficacy of agents which have possibility to improve cognitive deficits [827]. …”

Section: Discussionmentioning

confidence: 99%

Vanillin and 4-hydroxybenzyl alcohol attenuate cognitive impairment and the reduction of cell proliferation and neuroblast differentiation in the dentate gyrus in a mouse model of scopolamine-induced amnesia

Kim

Park

2017

Anat Cell Biol

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4-Hydroxy-3-methoxybenzaldehyde (vanillin) and 4-hydroxybenzyl alcohol (4-HBA) are natural phenolic compounds, which present in many plants and have diverse biological properties. In this study, we examined effects of vanillin and 4-HBA on learning and memory function, cell proliferation, and neuroblast differentiation in the hippocampal dentate gyrus in a mouse model of scopolamine-induced amnesia. Scopolamine (SCO; 1 mg/kg/day, intraperitoneally), vanillin, and 4-HBA (40 mg/kg/day, orally) were administered for 28 days. Treatment with scopolamine alone impaired learning and memory function in the Morris water maze and passive avoidance tests, in addition, the treatment significantly reduced cell proliferation and neuroblast differentiation in the dentate gyrus, which were examined by immunohistochemistry for Ki-67 (a classic marker for cell proliferation) and doublecortin (a marker for neuroblasts). However, treatment with vanillin or 4-HBA significantly attenuated SCO-induced learning and memory impairment as well as the reduction of cell proliferation and neuroblast differentiation in the dentate gyrus. These results indicate that vanillin and 4-HBA may be helpful in improving cognitive function and in increasing endogenous neuronal proliferation in the brain.

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Section: Discussionmentioning

confidence: 99%

Vanillin and 4-hydroxybenzyl alcohol attenuate cognitive impairment and the reduction of cell proliferation and neuroblast differentiation in the dentate gyrus in a mouse model of scopolamine-induced amnesia

Kim

Park

2017

Anat Cell Biol

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“…[174][175][176] A recent study has shown the beneficial effect of a commercial R. rosea extract (Extract 70) could improve learning ability and memory of scopolamine-induced memory impairment in rats in a dose-dependent manner (50 and 100 mg/kg/d). 177 In earlier studies, compound R. sachalinensis (Extract 71) 178 and a water extract (Extract 72) 179 showed their protective effects of liver function in the CCl 4 -induced liver injury rat model. The potential mechanism of Extract 71 could be its abilities to decrease the production of transforming growth factor β1 (TGF-β1), collagen, expression of messenger RNAs of TGF-β1, a1(I) and Na + /Ca 2+ exchanger, and inhibit the activation of hepatic stellate cells (HSCs).…”

Section: Anti-inflammatory and Analgesic Activitiesmentioning

confidence: 99%

“…A recent study has shown the beneficial effect of a commercial R. rosea extract (Extract 70 ) could improve learning ability and memory of scopolamine‐induced memory impairment in rats in a dose‐dependent manner (50 and 100 mg/kg/d) …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Tao

Cao

et al. 2019

Medicinal Research Reviews

106

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Rhodiola species, belonging to the family Crassulaceae, have long been used as an adaptogen, tonic, antidepressant, and antistress medicine or functional food in Asia and Europe. Due to the valuable application, the growing demand of Rhodiola species has led to a rapid decrease in resource content. This review aims to summarize the integrated research progress of seven mainstream Rhodiola species. We first outline both traditional and current use of Rhodiola for the treatment of various diseases. A detailed summary and comparison of chemical, pharmacological, toxicological, and clinical studies of various Rhodiola species highlight recent scientific advances and gaps, which gives insights into the understanding of Rhodiola application and would be helpful to improve the situation of biological resources and diversities of Rhodiola plants.

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“…In detail, R. rosea regulates various components of the antioxidant, anti-inflammatory, neuroendocrine, neurotrophic and neurotransmitter receptor pathways, which are likely associated with both its neuroprotective potential and beneficial effects on mood [15]. R. rosea increases the levels of both monoamines and acetylcholine (Ach) in nerve terminals and is likely bound to its mental health-promoting effects concerning both mood and cognition [91,[115][116][117][118][119][120][121]. However, compared with S. baicalenis and H. erinaceus, R. rosea produces more significant effects at the level of the 5-HT system, by increasing 5-HT and 5-HT1A receptor levels [121,122].…”

Section: Complementary Effects Of S Baicalensis H Erinaceus and Rmentioning

confidence: 99%

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

et al. 2020

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Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of herbal compounds are reported to produce both neuroprotective and psychotropic activities which may help to combat mental disorders such as depression, anxiety, sleep disturbances and cognitive alterations. In the present manuscript, we focus on three herbs which appear effective in mitigating anxiety or depression with favourable risk-benefit profiles, namely Scutellaria baicalensis (S. baicalensis), Hericium erinaceus (H. erinaceus) and Rhodiola rosea (R. rosea). These three traditional folk medicinal herbs target the main biochemical events that are implicated in mental disorders, mimicking, to some extent, the mechanisms of action of conventional antidepressants and mood stabilizers with a wide margin of tolerability. In detail, they rescue alterations in neurotransmitter and neuro-endocrine systems, stimulate neurogenesis and the synthesis of neurotrophic factors, and they counteract oxidative stress, mitochondrial dysfunction and inflammation. Albeit the encouraging results that emerge from both experimental and clinical evidence, further studies are needed to confirm and better understand the mental-health promoting, and specifically, the antidepressant effects of these herbs.

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Beneficial effect of commercial Rhodiola extract in rats with scopolamine-induced memory impairment on active avoidance

Cited by 22 publications

References 22 publications

Vanillin and 4-hydroxybenzyl alcohol attenuate cognitive impairment and the reduction of cell proliferation and neuroblast differentiation in the dentate gyrus in a mouse model of scopolamine-induced amnesia

Vanillin and 4-hydroxybenzyl alcohol attenuate cognitive impairment and the reduction of cell proliferation and neuroblast differentiation in the dentate gyrus in a mouse model of scopolamine-induced amnesia

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

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