Effects of Rhodiola on production, health and gut development of broilers reared at high altitude in Tibet

Li, Long; Wang, Honghui; Zhao, Xin

doi:10.1038/srep07166

Cited by 20 publications

(24 citation statements)

References 39 publications

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“…The comparative results of the BW and tibia parameters showed that the BWs, T. Weights, T. lengths, and T. growth plate widths of the TBCs were markedly lower than those of the AACs. Additionally, the T. Weight index and T. growth plate width index were also lower, suggesting that the slow growth of TBCs may be related to the local hypoxic climate 31 (Fig. 1c–h ).…”

Section: Discussionmentioning

confidence: 99%

Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens

Huang

Rehman

Lan

et al. 2017

Sci Rep

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Tibial dyschondroplasia (TD) is an intractable poultry problem that is characterized by the appearance of non-vascularized and non-mineralized cartilage masses in tibial growth plates (TGPs). However, the role of angiogenesis inhibition in the occurrence of TD remains unknown. In this study, we found that, compared to low-altitude Arbor Acres chickens (AACs), high-altitude Tibetan chickens showed higher tibial vascular distributions that were accompanied by up-regulation of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor A (VEGFA) and VEGF receptors. These observations provide insights into hypoxia-induced angiogenesis, which may be related to the absence of TD in high-altitude native Tibetan chickens. Importantly, hypoxia experiments also showed that during hypoxia, tibial angiogenesis was enhanced, which was due to pro-angiogenic factor up-regulation (including VEGFA, VEGFR1, VEGFR2, and IL-8), in AACs. Moreover, we observed that thiram-induced TD could strongly inhibit tibial angiogenesis in the hypertrophic zone through coordinated down-regulation of HIF-1α and pro-angiogenic factors, leading to a disruption in the blood supply to the TGP. Taken together, these findings reveal that the occurrence of TD is highly associated with inhibition of tibial angiogenesis through down-regulated expression of HIF-1α, VEGFA and VEGF receptors, which results in suppression of TGP development.

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Section: Discussionmentioning

confidence: 99%

Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens

Huang

Rehman

Lan

et al. 2017

Sci Rep

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“…[3], where the BW of AACs raised at high altitude was approximately 172.6 g on day 14. Meanwhile, previous reports on the BW of TBCs had lower numbers, but the ADFI remained the same as the AACs.…”

Section: Discussionmentioning

confidence: 99%

High altitude hypoxia as a factor that promotes tibial growth plate development in broiler chickens

et al. 2017

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Tibial dyschondroplasia (TD) is one of the most common problems in the poultry industry and leads to lameness by affecting the proximal growth plate of the tibia. However, due to the unique environmental and geographical conditions of Tibet, no case of TD has been reported in Tibetan chickens (TBCs). The present study was designed to investigate the effect of high altitude hypoxia on blood parameters and tibial growth plate development in chickens using the complete blood count, morphology, and histological examination. The results of this study showed an undesirable impact on the overall performance, body weight, and mortality of Arbor Acres chickens (AACs) exposed to a high altitude hypoxic environment. However, AACs raised under hypoxic conditions showed an elevated number of red blood cells (RBCs) and an increase in hemoglobin and hematocrit values on day 14 compared to the hypobaric normoxia group. Notably, the morphology and histology analyses showed that the size of tibial growth plates in AACs was enlarged and that the blood vessel density was also higher after exposure to the hypoxic environment for 14 days, while no such change was observed in TBCs. Altogether, our results revealed that the hypoxic environment has a potentially new role in increasing the blood vessel density of proximal tibial growth plates to strengthen and enhance the size of the growth plates, which may provide new insights for the therapeutic manipulation of hypoxia in poultry TD.

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“…In that study, all dead birds during the experimental period were necropsied to identify ascites-related mortality or non-ascites induced mortality. Non-ascites induced mortality accounted for 83.3% of the total mortality and ascites induced mortality accounted for 16.7% of the total mortality during the first 2 weeks 1 . In addition, the production performance of chickens reared at high altitude is low 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…However, the mortality rates are high, causing great economic losses to farmers. Our previous study showed that the mortality of commercial broiler chickens reared in Linzhi city (average 2,986 m above the sea level) was about 30% during a 42 days rearing period, with approximately 50% of the death occurring during the first 14 days 1 . In that study, all dead birds during the experimental period were necropsied to identify ascites-related mortality or non-ascites induced mortality.…”

Section: Introductionmentioning

confidence: 99%

Effects of oxygen levels and a Lactobacillus plantarum strain on mortality and immune response of chickens at high altitude

Wang

Liu

et al. 2019

Sci Rep

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Chickens reared in high altitude regions suffer from a high mortality, possibly due to poor immune responses induced by hypoxia. This experiment was conducted to evaluate whether increasing the oxygen level or administration of a probiotic could improve mortality and immune response of chickens at high altitude (2,986 m above the sea level). One-d-old chickens were randomly allocated to 1 of 6 treatments in a 2 × 3 factorial arrangement. The first factor was the oxygen level (low and high), while the second factor was the diet (basal diet, basal diet containing aureomycin, and basal diet plus L. plantarum). Increasing the oxygen level significantly reduced the mortality and improved immune responses. The levels of IgA, IgG, IL-10 and anti-BSA antibodies were significantly higher, while IL-1β, LITAF were significantly lower in chickens reared in the high-oxygen room. In the low-oxygen room, L. plantarum significantly decreased the mortality of chickens compared with the other 2 groups. Moreover, L. plantarum significantly increased the levels of IgA, anti-BSA antibodies, IL-10 and decreased IL-1β, LITAF compared with the control group. These results demonstrated that increasing oxygen level or administration of L. plantarum can improve health status of chickens in high altitude regions.

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Effects of Rhodiola on production, health and gut development of broilers reared at high altitude in Tibet

Cited by 20 publications

References 39 publications

Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens

Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens

High altitude hypoxia as a factor that promotes tibial growth plate development in broiler chickens

Effects of oxygen levels and a Lactobacillus plantarum strain on mortality and immune response of chickens at high altitude

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