Effects of oxygen levels and a Lactobacillus plantarum strain on mortality and immune response of chickens at high altitude

Abstract

Chickens reared in high altitude regions suffer from a high mortality, possibly due to poor immune responses induced by hypoxia. This experiment was conducted to evaluate whether increasing the oxygen level or administration of a probiotic could improve mortality and immune response of chickens at high altitude (2,986 m above the sea level). One-d-old chickens were randomly allocated to 1 of 6 treatments in a 2 × 3 factorial arrangement. The first factor was the oxygen level (low and high), while the second factor was the diet (basal diet, basal diet containing aureomycin, and basal diet plus L. plantarum). Increasing the oxygen level significantly reduced the mortality and improved immune responses. The levels of IgA, IgG, IL-10 and anti-BSA antibodies were significantly higher, while IL-1β, LITAF were significantly lower in chickens reared in the high-oxygen room. In the low-oxygen room, L. plantarum significantly decreased the mortality of chickens compared with the other 2 groups. Moreover, L. plantarum significantly increased the levels of IgA, anti-BSA antibodies, IL-10 and decreased IL-1β, LITAF compared with the control group. These results demonstrated that increasing oxygen level or administration of L. plantarum can improve health status of chickens in high altitude regions.

Dietary Lactobacillus plantarum improves the growth performance and intestinal health of Pekin ducks

“…Similarly, previous studies have reported that supplementation with LP enhanced growth performance of chicken ( Peng et al., 2016 ; Trabelsi et al., 2016 ). On the contrary, Wang et al. (2019b) and Deepthi et al.…”

Horizontally Acquired Polysaccharide-Synthetic Gene Cluster From Weissella cibaria Boosts the Probiotic Property of Lactiplantibacillus plantarum

“…EPSs also play a role in the inflammatory response of the host epithelial cells ( Dertli et al, 2015 ; Jiang and Yang, 2018 ). Previously, LTC-113 showed excellent probiotic activity in protecting newly hatched chicken from S. typhimurium infection and decreasing the mortality ( Wang et al, 2018 , 2019 ). Data from current study revealed that the cpsWc -derived EPSs are the main driving power for the probiotic property.…”

“…LTC-113 can protect newly hatched chicks from intestinal barrier disruption by Salmonella typhimurium infection via regulating the expression of tight junction genes and inflammatory meditators and decreasing the S. typhimurium colonization (Wang et al, 2018). Moreover, another study also found LTC-113 significantly decreased chickens' mortality and improved the health status of chickens breeding in high altitude regions (Wang et al, 2019). In this study, we sought to investigate whether EPS plays a role in the probiotic properties of LTC-113, and lay the groundwork for understanding the molecular basis of its probiotic activity using genomic, biochemical, biological, and engineering approaches.…”

Managing broiler production challenges at high altitude

“…The levels of cytokines can also be influenced by hypoxia, thereby disrupting the balance between proinflammatory and anti-inflammatory cytokines. Moreover, Wang et al (2019) found that the levels of IgA, IgG and IL-10 were significantly higher in birds reared at high altitude.…”

“…Moreover, Wang et al. (2019) found that the levels of IgA, IgG and IL‐10 were significantly higher in birds reared at high altitude.…”