Effects of reversible inactivation of the dorsomedial hypothalamus on panic- and anxiety-related responses in rats

Nascimento, Juliana O.G.; Zangrossi, Hélio; Viana, Milena de Barros

doi:10.1590/s0100-879x2010007500075

Cited by 18 publications

(14 citation statements)

References 18 publications

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“…The absence of involvement of the DMH with ETM escape responses also contrasts with a previous study performed by our research group [23]. In this particular study, it was shown that intra-DMH injection of the GABAA agonist muscimol significantly impaired ETM escape, not altering, however, ETM avoidance.…”

Section: Discussioncontrasting

confidence: 98%

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Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze

Silva

Pereira

Céspedes

et al. 2014

Behavioural Brain Research

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Section: Discussioncontrasting

confidence: 98%

“…In fact, the electrical stimulation of the DMH induces escape behavior and autonomic arousal that resemble the ones presented by animals when facing natural threats [18][19][20]. Administration of glutamate agonists [13,21] and of GABA antagonists into the structure [22,23] also evokes a similar defense pattern.…”

Section: Introductionmentioning

confidence: 99%

Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze

Silva

Pereira

Céspedes

et al. 2014

Behavioural Brain Research

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“…The dose used in the acquisition experiment, however, was the same dose that was shown to effectively inhibit the expression of CD, suggesting that this dose of muscimol was sufficient to inhibit the nucleus accumbens. In addition, there are also previous studies indicating that a similar dose of muscimol alters panic/anxiety behavior or feeding behavior after infusion into the hypothalamus [35] or the amygdala [36], respectively.…”

Section: Discussionmentioning

confidence: 93%

“…Infusion of this dose into other brain areas has been shown to be effective in altering behavior. For example, 0.5 nmol of muscimol has been infused unilaterally into the dorsomedial hypothalamus to significantly decrease escape from the open arms in the elevated T-maze[35], a measure of anxiety. In addition, a bilateral infusion of 0.5 nmol muscimol into the amygdala is also effective in reducing intake of palatable food in rats[36].…”

Section: Methods and Proceduresmentioning

confidence: 99%

The role of the nucleus accumbens in the acquisition and expression of conditioned defeat

Luckett

Norvelle

Huhman

2012

Behavioural Brain Research

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When Syrian hamsters (Mesocricetus auratus) are defeated by a larger, more aggressive hamster, they subsequently exhibit submissive and defensive behavior, instead of their usual aggressive and social behavior, even towards a smaller, non-aggressive opponent. This change in behavior is termed conditioned defeat, and we have found that the amygdala, bed nucleus of the stria terminalis, and ventral hippocampus, among others, are crucial brain areas for either the acquisition and/or expression of this behavioral response to social stress. In the present study, we tested the hypothesis that the nucleus accumbens is also a necessary component of the circuit mediating the acquisition and expression of conditioned defeat. We found that infusion of the GABAA agonist muscimol into the nucleus accumbens prior to defeat training failed to affect acquisition of conditioned defeat, but infusion prior to testing significantly decreased submissive behavior and significantly increased aggressive behavior directed toward the non-aggressive intruder. These data indicate that, unlike the basolateral complex of the amygdala, the nucleus accumbens is not a critical site for the plasticity underlying conditioned defeat acquisition, but it does appear to be an important component of the circuit mediating the expression of the behavioral changes that are produced in response to a previous social defeat. Of note, this is the first component of the putative “conditioned defeat neural circuit” wherein we have found that pharmacological manipulations are effective in restoring the territorial aggressive response in previously defeated hamsters.

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“…Both nuclei are depicted as part of a neurobiological substrate controlling rodents’ avoidance and defensive behaviors, related to fear, anxiety and panic-like responses (31, 32). Specifically, the manipulation of GABAA receptor in both nuclei was shown to modulate rodents’ defensive behaviour, utilized as an experimental model of panic attack (33, 34).…”

Section: Discussionmentioning

confidence: 99%

Emotional regulatory function of receptor interacting protein 140 revealed in the ventromedial hypothalamus

Flaisher-Grinberg

Tsai

Feng

et al. 2014

Brain, Behavior, and Immunity

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Receptor-interacting protein (RIP140) is a transcription co-regulator highly expressed in macrophages to regulate inflammatory and metabolic processes. However, its implication in neurological, cognitive and emotional conditions, and the cellular systems relevant to its biological activity within the central nervous system are currently less clear. A transgenic mouse line with macrophage-specific knockdown of RIP140 was generated (MΦRIPKD mice) and brain-region specific RIP140 knockdown efficiency evaluated. Mice were subjected to a battery of tests, designed to evaluate multiple behavioral domains at naïve or following site-specific RIP140 re-expression. Gene expression analysis assessed TNF-α, IL-1β, TGF-1β, IL1-RA and Neuropeptide Y (NPY) expression, and in-vitro studies examined the effects of macrophage’s RIP140 on astrocytes’ NPY production. We found RIP140 expression was dramatically reduced in macrophages within the ventromedial hypothalamus (VMH) and the cingulate cortex of MΦRIPKD mice. These animals exhibited increased anxiety- and depressive-like behaviors. VMH-targeted RIP140 re-expression in MΦRIPKD mice reversed its depressive- but not its anxiety-like phenotype. Analysis of specific neurochemical changes revealed reduced astrocytic-NPY expression within the hypothalamus of MΦRIPKD mice, and in-vitro analysis confirmed that conditioned medium of RIP140-silnenced macrophage culture could no longer stimulate NPY production from astrocytes. The current study revealed an emotional regulatory function of macrophage-derived RIP140 in the VMH, and secondary dysregulation of NPY within hypothalamic astrocyte population, which might be associated with the observed behavioral phenotype of MΦRIPKD mice. This study highlights RIP140 as a novel target for the development of potential therapeutic and intervention strategies for emotional regulation disorders.

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Effects of reversible inactivation of the dorsomedial hypothalamus on panic- and anxiety-related responses in rats

Cited by 18 publications

References 18 publications

Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze

Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze

The role of the nucleus accumbens in the acquisition and expression of conditioned defeat

Emotional regulatory function of receptor interacting protein 140 revealed in the ventromedial hypothalamus

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