Effects of Resveratrol Supplementation in Nrf2 and NF-κB Expressions in Nondialyzed Chronic Kidney Disease Patients: A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial

Saldanha, Juliana F.; Leal, Viviane O.; Rizzetto, Felipe; Grimmer, Gustavo H.; Ribeiro-Alves, Marcelo; Daleprane, Julio Beltrame; Carraro-Eduardo, José Carlos

doi:10.1053/j.jrn.2016.06.005

Cited by 62 publications

(48 citation statements)

References 35 publications

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“…In a pilot study in nondialyzed CKD patients, none of the proinflammatory and antioxidant biomarkers were, however, found to be improved after resveratrol treatment. Investigators suggested that additional studies with different doses and/or duration of treatment may be required for the better elucidation of resveratrol's efficacy in these patients …”

Section: Completed Clinical Trialsmentioning

confidence: 99%

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Health benefits of resveratrol: Evidence from clinical studies

Singh

Verma

et al. 2019

Medicinal Research Reviews

354

238

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Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing. Resveretrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The polyphenol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy. The molecular basis for the pleiotropic activities of resveratrol are based on its ability to modulate multiple cell signaling molecules such as cytokines, caspases, matrix metalloproteinases, Wnt, nuclear factor‐κB, Notch, 5′‐AMP‐activated protein kinase, intercellular adhesion molecule, vascular cell adhesion molecule, sirtuin type 1, peroxisome proliferator‐activated receptor‐γ coactivator 1α, insulin‐like growth factor 1, insulin‐like growth factor‐binding protein 3, Ras association domain family 1α, pAkt, vascular endothelial growth factor, cyclooxygenase 2, nuclear factor erythroid 2 like 2, and Kelch‐like ECH–associated protein 1. Although the clinical utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use. In this regard, the recently produced micronized resveratrol formulation called SRT501, shows promise. This review discusses the currently available clinical data on resveratrol in the prevention, management, and treatment of various diseases and disorders. Based on the current evidence, the potential utility of this molecule in the clinic is discussed.

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Section: Completed Clinical Trialsmentioning

confidence: 99%

“…Investigators suggested that additional studies with different doses and/or duration of treatment may be required for the better elucidation of resveratrol's efficacy in these patients. 172 Overall, the efficacy of resveratrol against kidney diseases is demonstrated only in three clinical trials.…”

mentioning

confidence: 99%

Health benefits of resveratrol: Evidence from clinical studies

Singh

Verma

et al. 2019

Medicinal Research Reviews

354

238

View full text Add to dashboard Cite

show abstract

“…Its antioxidant activity is due to the inhibition of lipid peroxidation, the ability of chelate metal ions and the direct action of radical scavenging. Moreover, resveratrol enhances antioxidant enzyme production and modulates nuclear factors involved in inflammation and oxidative stress, such as Nrf2 and NF-κB [143]. In fact, NF-κB activation plays a key role in the development and progression of CKD and its related disorders [144].…”

Section: Plant-derived Metabolitesmentioning

confidence: 99%

Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites

Rapa

Iorio

Campiglia

et al. 2019

IJMS

275

208

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Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary.

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“…A study by O'Donovan et al indicated that suicidal ideation is associated with elevated inflammation in patients with major depressive disorder (14). Previous reports have also demonstrated that resveratrol can effectively inhibit endothelial degeneration and prevent the production of tumor necrosis factor α in patients with coronary artery disease (15), and has also shown beneficial effects in patients with chronic kidney disease through the downregulation of nuclear factor erythroid 2-related factor 2 and nuclear factor-κB in a randomized, double-blind, placebo-controlled, crossover clinical trial (16). In addition, Rodrigues et al described the potential association between oxidative stress and genetic vulnerability in major depressive disorder and Alzheimer's disease (17), and the effects of oxidative and nitrosative stress in accelerated aging and major depressive disorder have also been discussed in a previous study (18).…”

Section: Introductionmentioning

confidence: 98%

Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellularï¿½signal-regulated kinase/cAMP signal transduction pathway

Wang

et al. 2018

Mol Med Report

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Depressive disorder is a mental health disorder caused by the dysfunction of nerve regeneration, neuroendocrine and neurobiochemistry, which frequently results in cognitive impairments and disorder. Evidence has shown that resveratrol offers benefits for the treatment of depressive disorder. In the present study, the therapeutic effects of resveratrol were investigated and the potential mechanisms mediated by resveratrol were analyzed in hippocampal neuron cells. The anti‑oxidative stress and anti‑inflammatory properties of resveratrol were also examined in vitro and in vivo. The results revealed that resveratrol administration inhibited the inflammation in hippocampal neuron cells induced by ouabain. Oxidative stress in the hippocampal neuron cells was ameliorated by resveratrol treatment in vitro and in vivo. In addition, the apoptosis of hippocampal neuron cells was inhibited by the upregulation of anti‑apoptotic genes, including P53, B‑cell lymphoma‑2 (Bcl‑2) and Bcl‑2‑associated death promoter, and the downregulation of the cleaved caspase‑3 and caspase‑9. The analysis of the mechanism revealed that that resveratrol treatment suppressed the apoptosis of hippocampal neuron cells through the NETRIN1‑mediated extracellular signal‑regulated kinase/cAMP signal transduction pathway. The results of the in vivo assay showed that resveratrol treatment led to improvements in cognitive competence, learning memory ability and anxiety in a mouse model of depressive disorder induced by ouabain. In conclusion, these results indicated that resveratrol treatment had protective effects against oxidative stress and neuroinflammatory pathogenesis through the NETRIN1‑mediated extracellular signal‑regulated kinase/cAMP signal transduction pathway, suggesting that resveratrol treatment may be a potential antidepressant agent for the treatment of depressive disorder.

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Effects of Resveratrol Supplementation in Nrf2 and NF-κB Expressions in Nondialyzed Chronic Kidney Disease Patients: A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial

Cited by 62 publications

References 35 publications

Health benefits of resveratrol: Evidence from clinical studies

Health benefits of resveratrol: Evidence from clinical studies

Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites

Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellularï¿½signal-regulated kinase/cAMP signal transduction pathway

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