Effects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in rats

Koz, Sema T.; Etem, Ebru Önalan; Baydaş, Gıyasettin; Yüce, Hüseyin; Ozercan, Halil Ibrahim; Kuloğlu, Tuncay; Köz, Süleyman; Etem, Arzu; Demir, Nevgül

doi:10.1016/j.brainres.2012.09.026

Cited by 33 publications

(23 citation statements)

References 70 publications

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“…Nowadays, many herbal drugs and their active ingredients can protect against chemical-induced cognitive deficits (Koz et al, 2012;Lan et al, 2012;Xian et al, 2011Xian et al, , 2012. Paeoniflorin, a monoterpene glycoside isolated from the aqueous extract of the dry root of Paeonia, has been identified as a main active ingredient in Radix Paeoniae Alba.…”

Section: Introductionmentioning

confidence: 99%

Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats

Lan

Chen

et al. 2013

Brain Research

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Section: Introductionmentioning

confidence: 99%

Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats

Lan

Chen

et al. 2013

Brain Research

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“…The major mechanism by which L-methionine induced memory impairment may be related to increased oxidative stress levels in the brain due to development of hyper-homocystenemia [10-13]. It is believed that hyper-homocystenemia in cells leads to auto-oxidation of thiol groups that generates hydrogen peroxide and the reactive radical oxygen species, superoxide and hydroxyl radical, and, thus, leads to oxidative stress [28-31].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies on animals have shown that chronic administration of L-methionine results in hyperhomocysteinemia condition [4, 5] and the subsequent development of cerebrovascular diseases including stroke [6]; atherosclerosis [7, 8], and vascular dementia [9]. In addition, hyperhomocysteinemia is associated with increased levels of oxidative stress and lipid peroxidation that interfere with memory formation [5, 10-13]. Hyperhomocysteinemia also contributes to the increased risk of dysfunction in endothelial cells that may interfere with blood supply to brain and the subsequent cognitive decline [13].…”

Section: Introductionmentioning

confidence: 99%

Metformin Eased Cognitive Impairment Induced by Chronic L-methionine Administration: Potential Role of Oxidative Stress

Alzoubi

Khabour

Al‐Azzam

et al. 2014

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Chronic administration of L-methionine leads to memory impairment, which is attributed to increase in the level of oxidative stress in the brain. On the other hand, metformin is a commonly used antidiabetic drug with strong antioxidant properties. In the current study, we tested if chronic metformin administration prevents memory impairment induced by administration of L-methionine. In addition, a number of molecules related to the action of metformin on cognitive functions were examined. Both metformin and L-methionine were administered to animals by oral gavage. Testing of spatial learning and memory was carried out using radial arm water maze (RAWM). Additionally, hippocampal levels or activities of catalase, thiobarbituric acid reactive substances (TBARs), glutathione peroxidase (GPx), glutathione (GSH), oxidized glutathione (GSSG) and GSH/GSSG ratio were determined. Results showed that chronic L-methionine administration resulted in both short- and long- term memory impairment, whereas metformin treatment prevented such effect. Additionally, L-methionine treatment induced significant elevation in GSSG and TBARs, along with reduction in GSH/GSSG ratio and activities of catalase, and GPx. These effects were shown to be restored by metformin treatment. In conclusion, L-methionine induced memory impairment, and treatment with metformin prevented this impairment probably by normalizing oxidative stress in the hippocampus.

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“…Recent studies supported the fact that elevation of circulating homocysteine is associated with inflammation. Level of circulating homocysteine can be effectively reduced by the administration of anti-inflammatory medications 21 . Current data have suggested the possible pathogenetic implications for Hhcy in inflammatory bowel disease (IBD) suggesting that Hcy may act as a pro-inflammatory and immuno-stimulating molecule 6 .…”

Section: Measurement Of Homocysteine and Crp (Inflammatory Marker)mentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:The present study was designed to evaluate the effect of Helix aspersa crude extract on colonic injury resulting from hyperhomocysteinemia induced by feeding rat's high methionine diet. Wistar albino rats (200-250g) were divided into four groups. Hyperhomocysteinemia (Hhcy) was induced by methionine treatment (1g/kg/day) for 15 days. M group received only Methionine, MH and MP received Methionine and Helix aspersa Crude Extract (8g/kg/day) or Prednisolone (4 mg/kg/day) respectively at the 8th day until the end of experimentation. Prednisolone was used as a standard drug. At the end plasma homocysteine and Creactive protein were evaluated, followed by colon histopathological investigations. Methionine treatment induced significant increase (P <0.001) in homocysteine and CRP levels in plasma as compared to control rats. Helix aspersa crude extract induces significant decrease of homocysteine (P <0.001) and CRP (P <0.01) levels as compared with experimental control group. The results were comparable to those obtained with prednisolone, a standard anti-inflammatory drug. Histological assessment showed colonic tissue damages in methionine treated group compared to control (P <0.001) as mucosal inflammation, crypt damage and hyperemia. Crude extract markedly reduces the damage induced by the Hhcy and preserved the histoarchitecture of colonic tissue compared to M group (P <0.001). This study provides clear evidence that Helix aspersa crude extract treatment decrease the major inflammatory markers homocysteine and CRP. Also it acts as a potent protective agent of colon against the inflammatory state induced by elevated level of plasma homocysteine.

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Effects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in rats

Cited by 33 publications

References 70 publications

Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats

Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats

Metformin Eased Cognitive Impairment Induced by Chronic L-methionine Administration: Potential Role of Oxidative Stress

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