Effects of Resveratrol and ACE Inhibitor Enalapril on Glucose and Lipid Profiles in Mice

Pinheiro, Thaisa de Almeida; Feltenberger, John David; Andrade, João Marcus Oliveira; Ferreira, Emíllio César Neves; Lelis, Deborah de Farias; Guimarães, André Luiz Sena; Paula, Alfredo Maurício Batista de; Caldeira, Antônio Prates; Santos, Sérgio Henrique Sousa

doi:10.2174/0929866524666170728153600

Cited by 15 publications

(8 citation statements)

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“…ACE inhibition is a standard approach against hypertension. A recent study showed that co-administration of ACE inhibitor enalapril and resveratrol improved glucose and lipid mice profiles by modulating expression of some lipogenesis genes by decreasing mRNA expression of fatty acid synthase ( Fasn ), acetyl-CoA carboxylase alpha ( Acaca ), and Pparg [ 49 ] in a way that is similar to the results of our study ( Figure 4 and Figure 5 ). Their results indicate that these inhibitory peptides are ones of the strong candidates for anti-obese constituents also in PM.…”

Section: Discussionsupporting

confidence: 89%

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

et al. 2018

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(1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases.

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Section: Discussionsupporting

confidence: 89%

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

et al. 2018

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“…Despite a positive effect of antihypertensive drugs over blood glucose was found (de Almeida Pinheiro et al., 2017), the present study did not show that trend since there was no significant decrease in that parameter when captopril was supplied, according to Figure 3.…”

Section: Resultscontrasting

confidence: 81%

“…The lowest TG value after the 3 weeks of assessment was obtained when captopril drug was supplied (T 5 ), suggesting a relationship between the antihypertensive treatment and the concentration of TG. Regarding this topic, an association between captopril and resveratrol (a phenolic compound) over the improvement of the lipid profile was reported in mice after 8 months of treatment (de Almeida Pinheiro et al., 2017).…”

Section: Resultsmentioning

confidence: 99%

Impact of consumption of cooked red and blackChenopodium quinoaWilld. over blood lipids, oxidative stress, and blood glucose levels in hypertension‐induced rats

et al. 2020

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Background and objectives Hypertension is associated with the overproduction of free radicals, generating oxidative stress, which could contribute to the lipid peroxidation, altering the blood lipid levels, and to the development of diseases such as diabetes. The aim of this work was to evaluate the bioactivity of cooked red and black quinoa over blood lipids, oxidative stress, and glucose levels in hypertension‐induced rats by the supply of the drug N (ω)‐nitro‐L‐arginine methyl ester (L‐NAME). Findings The consumption of red quinoa increased significantly (p < .05) the levels of high‐density lipoprotein (HDL). In addition, the quinoa consumption, regardless of the variety, not only increased the activity of antioxidant enzymes (superoxide dismutase and catalase), but also reduced blood glucose levels. The total phenolic compounds and total flavonoid content were higher in red than in black quinoa, while this latter obtained better values for the total antioxidant activity. Conclusions The presence of bioactive compounds in quinoa could be responsible for its capacity to improve the HDL levels, the in vivo antioxidant activity, and the levels of fasting blood glucose in hypertension‐induced rats. Significance and novelty Findings from this study could promote the consumption of quinoa, which seems to be a good source in the development of functional foods, in order to take advantages of its bioactivities.

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“…In view of these considerations, new therapeutic approaches were evaluated using the combination of bioactive compounds, a strategy that is characterized by (i) the use of lower doses of compounds than monotherapies with shorter supplementation periods to minimize possible side effects; and (ii) the involvement of compounds with protective effects that are exerted through different or similar mechanisms of action, thus allowing synergistic or additive actions and a more efficient control of the damaging effects [4,7]. For example, (i) preservation of liver tissue regeneration post-hepatectomy can be obtained by a L-3,3 ,5-triiodothyronine (T 3 ) plus methylprednisolone treatment [8]; (ii) high-fat diet (HFD)-induced liver steatosis can be diminished by n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) and extra virgin olive oil (EVOO) [9]; (iii) combined T 3 and fish oil supplementation suppresses ischemia-reperfusion inflammatory liver injury [10]; whereas (iv) resveratrol and enalapril improved glucose and lipid profiles by decreasing lipogenic gene expression [11]. Interestingly, an inverse correlation between serum free thyroxine (T 4 ) levels and hepatic steatosis was established in overweight and obese patients [12] or with elevated serum thyroid-stimulating hormone concentrations in overweight/obese children [13], while higher baseline levels of T 3 and T 4 predict more weight loss, but not weigh regain, in overweight/obese patients with normal thyroid function subjected to weight loss diets [14].…”

Section: Introductionmentioning

confidence: 99%

Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View

Valenzuela

Videla

2020

Nutrients

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Nonalcoholic fatty liver disease (NAFLD) is present in approximately 25% of the population worldwide. It is characterized by the accumulation of triacylglycerol in the liver, which can progress to steatohepatitis with different degrees of fibrosis, stages that lack approved pharmacological therapies and represent an indication for liver transplantation with consistently increasing frequency. In view that hepatic steatosis is a reversible condition, effective strategies preventing disease progression were addressed using combinations of natural products in the preclinical high-fat diet (HFD) protocol (60% of fat for 12 weeks). Among them, eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:5n-3, DHA), DHA and extra virgin olive oil (EVOO), or EPA plus hydroxytyrosol (HT) attained 66% to 83% diminution in HFD-induced steatosis, with the concomitant inhibition of the proinflammatory state associated with steatosis. These supplementations trigger different molecular mechanisms that modify antioxidant, antisteatotic, and anti-inflammatory responses, and in the case of DHA and HT co-administration, prevent NAFLD. It is concluded that future studies in NAFLD patients using combined supplementations such as DHA plus HT are warranted to prevent liver steatosis, thus avoiding its progression into more unmanageable stages of the disease.

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Effects of Resveratrol and ACE Inhibitor Enalapril on Glucose and Lipid Profiles in Mice

Abstract: In conclusion the resveratrol and enalapril association improved the glucose and lipid profiles by modulating the expression of some lipogenesis genes, which are critical regulators of metabolic homeostasis.

Cited by 15 publications

References 0 publications

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Impact of consumption of cooked red and blackChenopodium quinoaWilld. over blood lipids, oxidative stress, and blood glucose levels in hypertension‐induced rats

Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View

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