Effects of Restricted Fructose Access on Body Weight and Blood Pressure Circadian Rhythms

Senador, Danielle; Shewale, Swapnil V.; Irigoyen, Maria Cláudia; Elased, Khalid M.; Morris, Mariana

doi:10.1155/2012/459087

Cited by 8 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A diet that combined fructose with fat produced a profound syndrome with pathologies seen in multiple organ systems 45 . We have shown that dietary and liquid fructose produces autonomic aberrations along with changes in the brain expression of catecholaminergic and angiotensinergic markers 11,35 . As mentioned previously, changes in sleeping or eating patterns may have detrimental effects on physiological function.…”

Section: Discussionmentioning

confidence: 65%

“…Using radiotelemetry for chronic blood pressure monitoring in mice, we found that there was a light–dark pattern in the hypertensive response to a high‐fructose diet 11 . When fructose was given in the drinking water only during the light phase, there was an absence in the light–dark blood pressure rhythm 35 . Changes in circadian patterns are also associated with the risk of cardiovascular pathologies in humans; the peak period for heart attacks and strokes is seen in the early waking hours 36,37 …”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Timing of fructose intake: An important regulator of adiposity

Morris

Araujo

Pohlman

et al. 2011

Clin Exp Pharma Physio

Self Cite

View full text Add to dashboard Cite

Summary 1. Overconsumption of fructose produces glucose intolerance, autonomic abnormalities and renal dysfunction and may be related to the worldwide epidemic of obesity and diabetes. 2. Experiments were conducted to determine whether the time period (light or dark) of fructose consumption influenced the pathological consequences. C57BL mice were given standard chow and assigned to one of three groups: (i) control (n = 10), which received water over a 24 h period; (ii) FL (n = 11), which received 10% fructose solution during the 12 h light period; and (iii) FD (n = 11), which received 10% fructose solution during the 12 h dark period. 3. There was a time related increase in body weight for all groups (P < 0.01, 2 vs 6 wks). There was a greater increase in body fat in the FL group compared with the control and FD groups. The changes in adiposity occurred even though the total caloric intake was not significantly different among the groups (approximately 18 kcal/day). Total fluid (water + fructose) consumption was greater in the FD and FL groups compared with control at 6 weeks. Significant increases were noted for plasma insulin and leptin at 8 weeks, with highest levels in the FL compared with FD group (P < 0.05). There were no significant changes in glucose, glucose tolerance, cholesterol, triglycerides or adiponectin. 4. The results of the present study suggest that there is a mismatch in caloric consumption, metabolism and adiposity as related to the light–dark cycle of fructose consumption. These findings have clinical implications in the control of bodyweight, abdominal fat accumulation and Type 2 diabetes.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 96%

Timing of fructose intake: An important regulator of adiposity

Morris

Araujo

Pohlman

et al. 2011

Clin Exp Pharma Physio

Self Cite

View full text Add to dashboard Cite

show abstract

“…Fructose restriction to light phase additionally caused glucose intolerance and an attenuated amplitude of blood pressure rhythms. Ad libitum availability of fructose only caused glucose intolerance when compared to control animals without fructose (Senador et al, 2012 ). Another type of timed food restriction is done by dividing food intake into 4 or 6 meals equally divided over the L/D-cycle.…”

Section: Resultsmentioning

confidence: 99%

Rodent models to study the metabolic effects of shiftwork in humans

et al. 2015

View full text Add to dashboard Cite

Our current 24-h society requires an increasing number of employees to work nightshifts with millions of people worldwide working during the evening or night. Clear associations have been found between shiftwork and the risk to develop metabolic health problems, such as obesity. An increasing number of studies suggest that the underlying mechanism includes disruption of the rhythmically organized body physiology. Normally, daily 24-h rhythms in physiological processes are controlled by the central clock in the brain in close collaboration with peripheral clocks present throughout the body. Working schedules of shiftworkers greatly interfere with these normal daily rhythms by exposing the individual to contrasting inputs, i.e., at the one hand (dim)light exposure at night, nightly activity and eating and at the other hand daytime sleep and reduced light exposure. Several different animal models are being used to mimic shiftwork and study the mechanism responsible for the observed correlation between shiftwork and metabolic diseases. In this review we aim to provide an overview of the available animal studies with a focus on the four most relevant models that are being used to mimic human shiftwork: altered timing of (1) food intake, (2) activity, (3) sleep, or (4) light exposure. For all studies we scored whether and how relevant metabolic parameters, such as bodyweight, adiposity and plasma glucose were affected by the manipulation. In the discussion, we focus on differences between shiftwork models and animal species (i.e., rat and mouse). In addition, we comment on the complexity of shiftwork as an exposure and the subsequent difficulties when using animal models to investigate this condition. In view of the added value of animal models over human cohorts to study the effects and mechanisms of shiftwork, we conclude with recommendations to improve future research protocols to study the causality between shiftwork and metabolic health problems using animal models.

show abstract

“…Fructose overload in experimental animals has been associated with high triglyceride levels, adiposity, insulin resistance, and glucose intolerance [79–86]. These animals have been used by our group in order to understand the various aspects of obesity, dyslipidemia, and insulin resistance-associated cardiovascular changes [81–88]. We observed that an increased sympathetic modulation to the vessels and heart preceded metabolic dysfunction in fructose-consuming mice, thus suggesting that changes in autonomic modulation may be a triggering mechanism underlying the cluster of symptoms associated with cardiometabolic disease [83–86, 88].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Changes in Animal Models of Metabolic Syndrome

Lehnen

Rodrigues

Irigoyen

et al. 2013

Journal of Diabetes Research

View full text Add to dashboard Cite

Metabolic syndrome has been defined as a group of risk factors that directly contribute to the development of cardiovascular disease and/or type 2 diabetes. Insulin resistance seems to have a fundamental role in the genesis of this syndrome. Over the past years to the present day, basic and translational research has used small animal models to explore the pathophysiology of metabolic syndrome and to develop novel therapies that might slow the progression of this prevalent condition. In this paper we discuss the animal models used for the study of metabolic syndrome, with particular focus on cardiovascular changes, since they are the main cause of death associated with the condition in humans.

show abstract

Effects of Restricted Fructose Access on Body Weight and Blood Pressure Circadian Rhythms

Cited by 8 publications

References 52 publications

Timing of fructose intake: An important regulator of adiposity

Timing of fructose intake: An important regulator of adiposity

Rodent models to study the metabolic effects of shiftwork in humans

Cardiovascular Changes in Animal Models of Metabolic Syndrome

Contact Info

Product

Resources

About