Cardiovascular Changes in Animal Models of Metabolic Syndrome

Lehnen, Alexandre Machado; Rodrigues, Bruno; Irigoyen, Maria Cláudia; Angelis, Kátia De; Schaan, Beatriz D.

doi:10.1155/2013/761314

Cited by 32 publications

(22 citation statements)

References 109 publications

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“…It has been shown that fructose-fed rats present moderate hypertension and glucose intolerance, associated with high levels of plasma insulin, cholesterol and triglycerides [11,22-24]. In the present investigation, chronic fructose consumption induced an increase in triglyceride levels and arterial pressure, together with a decrease in insulin sensitivity, thus corroborating previous findings of our group [9,11].…”

Section: Discussionsupporting

confidence: 92%

Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model

Morvan

Lima

Machi

et al. 2013

Cardiovasc Diabetol

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BackgroundThe increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise training (LET) on metabolic, hemodynamic, ventricular and vascular morphological changes induced by fructose drinking in male rats.MethodsMale Wistar rats were divided into (n = 8 each) control (C), sedentary fructose (F) and ET fructose (FT) groups. Fructose-drinking rats received D-fructose (100 g/l). FT rats were assigned to a treadmill training protocol at low intensity (30% of maximal running speed) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, white adipose tissue (WAT) and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BS) was evaluated by the tachycardic and bradycardic responses. Right atria, left ventricle (LV) and ascending aorta were prepared to morphoquantitative analysis.ResultsLET reduced WAT (−37.7%), triglyceride levels (−33%), systolic AP (−6%), heart weight/body weight (−20.5%), LV (−36%) and aortic (−76%) collagen fibers, aortic intima-media thickness and circumferential wall tension in FT when compared to F rats. Additionally, FT group presented improve of BS, numerical density of atrial natriuretic peptide granules (+42%) and LV capillaries (+25%), as well as the number of elastic lamellae in aorta compared with F group.ConclusionsOur data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS.

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Section: Discussionsupporting

confidence: 92%

Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model

Morvan

Lima

Machi

et al. 2013

Cardiovasc Diabetol

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“…It consists of a mixture of equal parts (33% of each with 33% of inversion) of glucose, fructose, and invert sucrose 23,24 . Moreover, studies have found that sugar overload can promote metabolic, hemodynamic, structural, and functional disorders in rodents, increasing plasma insulin, leptin, triglycerides, glucose, and free fatty acids, leading to low glucose tolerance 25 , typical prediabetes characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, the mean energy intake of the group fed the cafeteria diet was lower than that of the control group, despite the cafeteria diet's high energy density and low nutrient density. The cafeteria diet consists of chocolate, biscuits, cookies, hot dogs, potato chips, and carbonated beverages, among others 25 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Molz¹,

Rael

Fischer

et al. 2017

Rev. Nutr.

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Objective: To evaluate whether vitamin C can help to prevent obesity and hyperglycemia in Wistar rats treated with excess invert sugar to induce prediabetes. Methods: One hundred-day-old Male Wistar rats with a mean weight of 336.58±23.43g were randomly assigned to the following groups: (1) control, receiving water (C); (2) invert sugar control, receiving a 32% watery solution of invert sugar; (3) vitamin C control, receiving a watery solution of vitamin C (60mg/L), and (4) vitamin C plus invert sugar, receiving a watery solution of vitamin C and invert sugar. All animals had access to chow and water ad libitum and were treated for 17 weeks. Prediabetes was assessed according to two criteria: obesity (based on body mass indexand peritoneal fat content) and impaired glucose tolerance (assessed by the intraperitoneal glucose tolerance test and expressed as area under the curve) . Results: Group invert sugar control gained significantly more weight (p=0.035) and visceral fat (p<0.001) than groups vitamin C control and vitamin C plus invert sugar. Consequently, groups vitamin C control and vitamin C plus invert sugar had gained as little body mass index as group C by the end of the experiment. Vitamin C decreased the fasting glycemia of both groups supplemented with vitamin C and normalized the glucose tolerance of group vitamin C plus invert sugar, whose area under the curve matched that of group C. Conclusion: Vitamin C has anti-obesogenic and glycemia-lowering effects in Wistar rats, which might be promising to prediabetics. Future studies are needed to understand the anti-obesogenic and anti-hyperglycemic mechanisms of vitamin C in prediabetes.

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“…Fructose overload in experimental animals is associated with increased body mass, insulin resistance, glucose and lipid metabolism disorders [10,[13][14]. High-fructose diet is also used in SHR to develop metabolic syndrome [10,15].…”

Section: Description Of the Methods And Facilitiesmentioning

confidence: 99%

“…This rat strain was chosen because arterial hypertension is prevalent CVD in Ukraine and is one of key components of metabolic syndrome. To provoke metabolic disorders in animals carbohydrate or fat overload is usually used [10][11][12]. We choose carbohydrate overload, according to modern nutritional pattern of Ukrainian people with metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%