Effects of Repeated Ether Stress on the Hypothalamic-Pituitary-Testes Axis in Adult Rats with Special Reference to Inhibin Secretion.

Tohei, Atsushi; Tomabechi, Taeko; Mamada, Masayuki; Akai, Makoto; Watanabe, Gen; Taya, Kazuyoshi

doi:10.1292/jvms.59.329

Cited by 33 publications

(18 citation statements)

References 40 publications

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“…In previous studies, surgical [2,29,36,50], physical [11,13,28,38,39], and social stress [43][44][45] resulted in decreased plasma levels of gonadotropins, inhibin and/or testosterone in humans, male primates and rats. However, in the present study, plasma levels of inhibin significantly increased on day 3 after vasectomy.…”

Section: Discussionmentioning

confidence: 86%

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

et al. 2011

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The present study was undertaken to clarify changes in secretions of FSH, LH, inhibin and testosterone, and sperm motility after bilateral vasectomy in adult male rats. Bilateral vasectomy was created surgically (treated group) and intact rats were used as control (control group). On days 3,5,7,14,30, 60, and 90 after surgery, plasma concentrations of FSH, LH, inhibin, and testosterone were measured by radioimmunoassay, and sperm motility characteristics were measured by computer-assisted sperm analysis (CASA). The results show that weights of epididymides significantly increased in vasectomized rats as compared to control rats. Histologically, damage to spermatogenesis was observed in vasectomized rats. Multinucleated giant cells were observed in the lumen of some seminiferous tubules, and there were degenerative spermatids in the epididymides of vasectomized rats. Plasma levels of LH, FSH, and testosterone only decreased on day 3 after vasectomy; however, plasma levels of ir-inhibin significantly increased on day 3 after vasectomy. In addition, the sperm motility parameters, straight-line velocity, curvilinear velocity, deviation of the sperm head from the mean trajectory and the maximum amplitude of lateral head displacement were decreased from day 60 after vasectomy. These results suggest that vasectomy reduces sperm motility starting from day 60 after vasectomy, and early bilateral vasectomy does not strongly affect the endocrine function of the testis, though it may result in damage to spermatogenesis in vasectomized rats.

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Section: Discussionmentioning

confidence: 86%

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

et al. 2011

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“…However, concentrations of ir-inhibin in the testicular interstitial fluid were significantly higher than in the control group until 3 days after the operation. Surgical [40,41], physical [42][43][44][45][46][47], and social [48][49][50] stress can result in an acute decline in plasma l e v e l s o f g o n a d o t r o p i n s , i n h i b i n , a n d / o r testosterone in adult male rats [51,52]. However, it must be pointed out that the expected reciprocal relationship between plasma FSH and inhibin B levels following early cryptorchidism in mature rats is clear.…”

Section: Discussionmentioning

confidence: 97%

Effects of Experimental Cryptorchidism on Sperm Motility and Testicular Endocrinology in Adult Male Rats

Ren

Medan

Ozu

et al. 2006

Journal of Reproduction and Development

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Abstract. The effect of induced cryptorchidism on testicular function and sperm motility was investigated. Bilateral cryptorchidism was created surgically in adult male rats (treated group), and sham-operated rats were used as a control group. Five rats from each group were sacrificed on days 1, 3, 5, and 7 after surgery. The percentage of motile spermatozoa began to decrease 1 day after the operation, followed by an abrupt decline 3 and 5 days later in cryptorchid rats. Furthermore, there were significant decreases in the other sperm motility parameters 5 days after inducement of cryptorchidism. In cryptorchid rats, plasma concentrations of LH, FSH, testosterone, and inhibin B were significantly lower than in the control group 1 day after the operation. Thereafter, plasma concentrations of LH, FSH, and testosterone gradually increased in the cryptorchid rats. On the other hand, plasma concentrations of inhibin B showed a further decline from day 3 after the operation onward. Concentrations of immunoreactive (ir)-inhibin, but not testosterone, in testicular interstitial fluid were remarkably increased until 3 days after surgery in the cryptorchid rats, and declined thereafter. Testicular response to human chorionic gonadotropin (hCG) for testosterone release was decreased in the cryptorchid rats compared with the control rats, indicating that heat stress to testes resulted in a reduction of the activity of Leydig cells and Sertoli cells. These results clearly indicate that heat stress to the testes resulted in a significant reduction of sperm activity within 3 days, and this was followed by changes in testicular endocrine function. Key words: Cryptorchidism, Heat stress, Inhibin B, Sperm motility, Testosterone (J. Reprod. Dev. 52: [219][220][221][222][223][224][225][226][227][228] 2006) ormal testicular descent is dependent on a series of complex endocrine and mechanical interactions [1]. In most mammalian species, the testis is kept approximately 4-5 C below body temperature. This lower temperature has been shown to be important for normal germ cell development and testicular function [2,3]. A slight increase in testicular temperature for a short period results in a rapid loss of mature germ cells [4,5], and the number of primary spermatocytes and spermatids drops rapidly [6]. In the field of animal production, summer sterility is a serious problem especially in male domestic animals, such as pigs, cattle, and stallions. In the rat, testicular damage caused by cryptorchidism is reversible, if the

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“…The anesthetic, di-ethyl ether, can act as a stressor and affect corticosterone levels (Tohei et al 1997;Raff et al 2003). To determine the possible effects of di-ethyl ether on hormonal profiles, I compared corticosterone levels in ten captive male mice kept in Zurich (Switzerland), when they were anaesthetized with ether, and when they were anaesthetized with methoxyflurane (Medical Developments International limited, Springvale, Australia).…”

Section: Blood Collectionmentioning

confidence: 99%

Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent

Schradin

2008

Hormones and Behavior

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Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent Schradin, C Schradin, C (2008). Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent. Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent AbstractAnimals have to adjust their physiology to seasonal changes, in response to variation in food availability, social tactics and reproduction. I compared basal corticosterone and testosterone levels in free ranging striped mouse from a desert habitat, comparing between the sexes, breeding and philopatric non-breeding individuals, and between the breeding and the non-breeding season. I expected differences between breeders and non-breeders and between seasons with high and low food availability. Basal serum corticosterone was measured from 132 different individuals and serum testosterone from 176 different individuals of free living striped mice. Corticosterone and testosterone levels were independent of age, body weight and not influenced by carrying a transmitter. The levels of corticosterone and testosterone declined by approximately 50% from the breeding to the non-breeding season in breeding females as well as non-breeding males and females. In contrast, breeding males showed much lower corticosterone levels during the breeding season than all other classes, and were the only class that showed an increase of corticosterone from the breeding to the non-breeding season. As a result, breeding males had similar corticosterone levels as other social classes during the non-breeding season. During the breeding season, breeding males had much higher testosterone levels than other classes, which decreased significantly from the breeding to the non-breeding season. My results support the prediction that corticosterone decreases during periods of low food abundance. Variation in the pattern of hormonal secretion in striped mice might assist them to cope with seasonal changes in energy demand in a desert habitat. AbstractAnimals have to adjust their physiology to seasonal changes, in response to variation in food availability, social tactics and reproduction. I compared basal corticosterone and testosterone levels in free ranging striped mouse from a desert habitat, comparing between the sexes, breeding and philopatric non-breeding individuals, and between the breeding and the non-breeding season. I expected differences between breeders and nonbreeders and between seasons with high and low food availability. Basal serum corticosterone was measured from 132 different individuals and serum testosterone from 176 different individuals of free living striped mice. Corticosterone and testosterone levels were independent of age, body weight and not influenced by carrying a transmitter.The levels of corticosterone and testosterone declined by approximately 50% from the breeding to the non-breeding season in breeding females as well as n...

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Effects of Repeated Ether Stress on the Hypothalamic-Pituitary-Testes Axis in Adult Rats with Special Reference to Inhibin Secretion.

Cited by 33 publications

References 40 publications

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

Effects of Experimental Cryptorchidism on Sperm Motility and Testicular Endocrinology in Adult Male Rats

Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent

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