Effects of repeat fenbendazole treatment in dairy calves with giardiosis on cyst excretion, clinical signs and production

O’Handley, Ryan; Cockwill, C. L.; Jelinski, Murray; McAllister, Tim A.; Olson, Merle E.

doi:10.1016/s0304-4017(00)00200-4

Cited by 39 publications

(24 citation statements)

References 23 publications

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“…After treatment with fenbendazole, giardiasis-infected animals recovered rapidly from the symptoms and poor weight gain (13). However, in some other treatment studies with fenbendazole or paromomycin sulfate, differences in mean body weight, average daily weight gain, or feed intake between the control and treated groups were not significant, although there was a slightly higher weight gain and lower occurrence of diarrhea in the treated groups (88,190). Rapid reinfection after antigiardial treatment was one possible reason for the failure to detect some benefits of the treatment.…”

Section: Public Health Importance Of Giardiasismentioning

confidence: 97%

Zoonotic Potential and Molecular Epidemiology ofGiardiaSpecies and Giardiasis

2011

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SUMMARY Molecular diagnostic tools have been used recently in assessing the taxonomy, zoonotic potential, and transmission of Giardia species and giardiasis in humans and animals. The results of these studies have firmly established giardiasis as a zoonotic disease, although host adaptation at the genotype and subtype levels has reduced the likelihood of zoonotic transmission. These studies have also identified variations in the distribution of Giardia duodenalis genotypes among geographic areas and between domestic and wild ruminants and differences in clinical manifestations and outbreak potentials of assemblages A and B. Nevertheless, our efforts in characterizing the molecular epidemiology of giardiasis and the roles of various animals in the transmission of human giardiasis are compromised by the lack of case-control and longitudinal cohort studies and the sampling and testing of humans and animals living in the same community, the frequent occurrence of infections with mixed genotypes and subtypes, and the apparent heterozygosity at some genetic loci for some G. duodenalis genotypes. With the increased usage of multilocus genotyping tools, the development of next-generation subtyping tools, the integration of molecular analysis in epidemiological studies, and an improved understanding of the population genetics of G. duodenalis in humans and animals, we should soon have a better appreciation of the molecular epidemiology of giardiasis, the disease burden of zoonotic transmission, the taxonomy status and virulences of various G. duodenalis genotypes, and the ecology of environmental contamination.

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Section: Public Health Importance Of Giardiasismentioning

confidence: 97%

Zoonotic Potential and Molecular Epidemiology ofGiardiaSpecies and Giardiasis

2011

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“…No sheep in this study were treated with 3 consecutive doses of any anthelmintic. Furthermore, studies in calves have shown that cyst suppression after 3 days of BZ treatment was either not complete or short acting in field conditions, and it has been proposed that this may reflect rapid re-infection in contaminated environments (O'Handley et al, 2000;Guerden et al, 2006;Geurden et al, 2010). Therefore any BZ treatments used in the present study were likely sub-therapeutic, and reinfection rapid.…”

Section: Parvum (But Not All Cryptosporidium Spp)mentioning

confidence: 78%

“…Cama et al (2008) reported that reinfection with both the same and different genotypes were common. In cattle, reinfection after treatment is common (O'Handley et al, 2000;Guerden et al, 2006;Geurden et al, 2010). Little is known about the situation in sheep.…”

Section: Parvum (But Not All Cryptosporidium Spp)mentioning

confidence: 99%

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Greater intensity and frequency of Cryptosporidium and Giardia oocyst shedding beyond the neonatal period is associated with reductions in growth, carcase weight and dressing efficiency in sheep

Jacobson

Williams

Yang

et al. 2016

Veterinary Parasitology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Haemonchus status (positive or negative) with lamb production were assessed using general linear models (HSCW and dressing %) and linear mixed effects models (live weight). HighCryptosporidium parvum shedding was associated with lower live weight, ranging 2.31-4.52kg over the 3 sampling occasions. Cryptosporidium parvum shedding was associated 3 with less HSCW in high (3.22kg less) and low (3.22kg less) shedding lambs post-weaning, and high (2.21kg less) and low (2.60kg less) shedding lambs pre-slaughter as well as lower dressing % (2.7% lower in high shedding lambs post-weaning). Cryptosporidium (all species) shedding pre-slaughter was associated with reduced dressing % in both high (1.25% lower) and low (1.21% lower) shedding lambs. Giardia shedding pre-slaughter was associated with 0.59kg less HSCW in high shedding lambs. Increased frequency of C.parvum and Giardia shedding in a specific animal (repeated detection) were associated with Abbreviations:HSCW: hot standard carcase weight WEC: Faecal worm egg count

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“…Other authors have reported that fenbendazole and albendazole have similar effects on giardiasis in calves and cattle [16][17][18] . In the present study, the reduction in daily cyst excretion increased more rapidly in the paromomycin groups than the albendazole group based on the cyst count on the first day.…”

Section: Discussionmentioning

confidence: 99%

Doğal İnfekte Giardiazisli Kuzuların Tedavisinde Albendazol ve İki Farklı Paromomisin Dozunun Etkisinin Karşılaştırılması

Albay¹,

Şahinduran²,

Adanir³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryGiardia duodenalis is a protozoan that infects a variety of vertebrates. It is a major cause of diarrhea in agricultural animals. There have been reports of clinical signs in cattle and sheep, which include diarrhea, dehydration and weight loss, however; there are limited drugs available for the treatment of giardiasis in animals. In this study, we compared the therapeutic effect of 20 mg albendazole, 50 mg and 100 mg paromomycin (kg body weight orally) for 3 successive days in lambs naturally infected with giardiasis. The efficacy of these drugs was evaluated based on reduction in cyst excretion. In the group treated with albendazole, no cysts were seen in the feces after treatment on D5 (day 5) in 7 lambs and on D8 in all animals. In the group treated with 50mg/kg of paromomycin, no cysts were seen in the feces after treatment on D2 in 3 lambs and on D6 in all animals. In the group treated with 100 mg/kg of paromomycin, there were no cysts after treatment on D2 in 5 lambs and on D6 in all of lambs. White blood cell (WBC) levels were high in all groups before treatment; paromomycin decreased the total leukocyte count more than albendasole. In the present study, we found paromomycin to be more effective than albendozole for the treatment of lambs with giardiasis for both treatment regiments mentioned above. Keywords: Albendazole, Paromomycin, Giardiasis, Lambs Doğal İnfekte Giardiazisli Kuzuların Tedavisinde Albendazol ve İki Farklı Paromomisin Dozunun Etkisinin Karşılaştırılması ÖzetGiardia duodenalis çeşitli omurgalılarda hastalık yapan bir protozoondur. Çiftlik hayvanlarında oluşan ishalin önemli sebeplerinden biridir. Sığır ve koyunlarda ishal, dehidrasyon ve kilo kaybı gibi klinik bulgular bildirilmiştir fakat çiftlik hayvanlarında giardiazis tedavisinde kullanılan ilaçlar sınırlıdır. Bu çalışmada doğal infekte giardiazisli kuzularda 3 gün oral kullanılan 20 mg Albendazol, 50 mg ve 100 mg Paromomisinin (kg canlı ağırlık) terapötik etkileri karşılaştırıldı. Bu ilaçların etkinliği kist atılımındaki azalmaya bakılarak değerlendirildi. Albendazol grubunda 5. günde 7 kuzuda ve 8. günde bütün hayvanlarda kist atılımı sıfırlandı. 50 mg/kg paromomisinle tedavi grubunda 2. günde 3 kuzu ve 6. günde bütün hayvanlarda kist atılımı sıfırlandı. 100 mg/kg paromomisinle tedavi grubunda ise 2. günde 5 kuzu ve 6. günde bütün hayvanlarda kist atılımı sıfırlandı. Tedavi öncesi lökosit değeri bütün gruplarda normalin üstünde tespit edildi. Paromomisin total lökosit sayısını albendazole göre daha fazla düşürdü. Sonuç olarak giardiazisli kuzuların tedavisinde paromomisin albendazole oranla etkili bulundu.

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Effects of repeat fenbendazole treatment in dairy calves with giardiosis on cyst excretion, clinical signs and production

Cited by 39 publications

References 23 publications

Zoonotic Potential and Molecular Epidemiology ofGiardiaSpecies and Giardiasis

Zoonotic Potential and Molecular Epidemiology ofGiardiaSpecies and Giardiasis

Greater intensity and frequency of Cryptosporidium and Giardia oocyst shedding beyond the neonatal period is associated with reductions in growth, carcase weight and dressing efficiency in sheep

Doğal İnfekte Giardiazisli Kuzuların Tedavisinde Albendazol ve İki Farklı Paromomisin Dozunun Etkisinin Karşılaştırılması

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