Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study

Koyu, Ezgi Bellikci; Sarer-Yurekli, B.P.; Akyön, Yakut; Köse, Fadime Aydın; Karagözlü, Cem; Özgen, A. Gökhan; Brinkmann, Annika; Nitsche, Andreas; Ergünay, Koray; Yılmaz, Engin; Büyüktuncer, Zehra

doi:10.3390/nu11092089

Cited by 93 publications

(80 citation statements)

References 80 publications

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“…It is a low-cost food, accessible to the general population, easy to handle and with great functional potential ( 18 ) due to its bioactive compounds ( 11 , 18 ) like exopolysaccharides, conjugated fatty acids and peptidases ( 11 , 16 ). Kefir consumption does not seem to result in negative effects ( 18 ) for adult humans ( 19 ) or animals ( 20 ). In kefir produced with whole milk, high cholesterol content can be observed, and in individuals with intolerance to lacteal proteins, allergic reactions may be observed, that can be avoided by replacing the milk matrices for water and sugar, which reinforces the absence of adverse effects of kefir ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Kefir and Intestinal Microbiota Modulation: Implications in Human Health

et al. 2021

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In the last decades changes in the pattern of health and disease in Latin America and in the world has been observed, with an increase in cases of chronic non-communicable diseases. Changes in intestinal microbiota composition can contribute to the development of these diseases and be useful in their management. In this context, the consumption of fermented foods with probiotic properties, such as kefir, stands out due to its gut microbiota-modulating capacity. There is an increasing interest in the commercial use of kefir since it can be marketed as a natural beverage containing health-promoting bacteria and has been gaining international popularity in Latin America. Also the consumption of these drinks in Latin America seems to be even more relevant, given the socioeconomic situation of this population, which highlights the need for disease prevention at the expense of its treatment. In this narrative review, we discuss how kefir may work against obesity, diabetes mellitus, liver disease, cardiovascular disorders, immunity, and neurological disorders. Peptides, bioactive compounds and strains occurring in kefir, can modulate gut microbiota composition, low-grade inflammation and intestinal permeability, which consequently may generate health benefits. Kefir can also impact on the regulation of organism homeostasis, with a direct effect on the gut-brain axis, being a possible strategy for the prevention of metabolic diseases. Further studies are needed to standardize these bioactive compounds and better elucidate the mechanisms linking kefir and intestinal microbiota modulation. However, due to the benefits reported, low cost and ease of preparation, kefir seems to be a promising approach to prevent and manage microbiota-related diseases in Latin America and the rest of the world.

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Section: Introductionmentioning

confidence: 99%

Kefir and Intestinal Microbiota Modulation: Implications in Human Health

et al. 2021

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“…Despite not reaching statistical significance, several of the changes were correlated with improvements in anthropometric measurements. 14 …”

Section: Resultsmentioning

confidence: 99%

Role of gut microbiota in metabolic syndrome: a review of recent evidence

Alveirinho

Freitas

Faleiro

2020

Porto Biomedical Journal

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The metabolic syndrome is a complex entity comprised of multiple cardiovascular risk factors grouped in a single individual, contributing to an increased rate of cardiovascular events which goes beyond what would be expected given the impact of each individual risk factor. It is a multifactorial condition whose complete pathogenesis is not yet fully understood. Several studies have shown that not only the intestinal microbiota and dysbiosis may play a role in its pathogenesis, but also that modulating said microbiota may play a role in treating or at least ameliorating the metabolic syndrome. The purpose of this article is to review some of the most recent evidence linking the gut microbiome and the metabolic syndrome to help further understand this relationship and try to identify further research directions.

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“…Vinderola et al (2006) proved that kefir activated immune system with down-regulation of Th2 response that promoted cell mediated immune response against tumor and pathogenic infection in mice. Previous studies performed by Bellikci-Koyu et al (2019) showed that consumption of kefir frequently for 12 weeks in patients having metabolic syndrome displayed microbiota alteration with the increase in Actinobacteria without any changes in Bacteroidetes and Proteobacteria population. Kefir possessed antioxidative, antibacterial and hepato-protective activity against CCl 4 induced liver toxicity in mice (AbdEl-Mogheith et al 2017).…”

Section: Kefirmentioning

confidence: 92%

Role of fermented dairy foods in human health

Kaur¹,

Gupta²,

Kapila³

et al. 2020

IJDS

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Unhealthy lifestyle and unbalanced diet are directly associated with diseases like inflammatory bowel diseases (IBD), diarrhea, hypersensitivity, irritable bowel syndrome, Helicobacter pylori infection, lactose intolerance, and gastroenteritis etc.The malfunction of the mediators of inflammation affect intestinal epithelial barrier functions by disruption of the physiological pathways. Fermented dairy foods influence human health through secretion of bioactive compounds and interaction of their inherent beneficial microbes with gut. Among all foods, fermented products have also been used as the most efficient vehicle for delivery of beneficial or probiotic microbes as they not only preferred by consumer being superior in sensory attributes during oral intake but also provide buffered media for survival of bacteria in harsh gastric environment. In-vitro and in-vivo studies have shown that fermented dairy products (fermented milk, curd, yogurt, cheese, koumiss, paneer and kefir) assisted in the maintenance of normal mucosal homeostasis and modulate the immune response in a positive fashion which provides protection against various metabolic and pathogen mediated diseases by anti-oxidative, antimicrobial, anti-fungal, anti-inûammatory, anti-diabetic and antiatherosclerotic activities. Cumulatively, this review focuses mainly on the health effects of fermented dairy foods.

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Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study

Cited by 93 publications

References 80 publications

Kefir and Intestinal Microbiota Modulation: Implications in Human Health

Kefir and Intestinal Microbiota Modulation: Implications in Human Health

Role of gut microbiota in metabolic syndrome: a review of recent evidence

Role of fermented dairy foods in human health

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