Effects of Red Ginseng extract on ultraviolet B‐irradiated skin change in C57BL mice

Abstract

Red Ginseng (the roots of Panax ginseng C.A. Meyer) is used clinically in China, Korea and Japan for various diseases, including atherosclerosis, hypertension and stress etc. Although Red Ginseng roots have traditionally been thought to have antiageing effects, the basis for this hearsay is unclear. This study examined the effects of Red Ginseng extract on ultraviolet B (UVB)-irradiated skin ageing in mice. Oral administration of Red Ginseng extract (20 or 60 mg/kg, twice daily) prevented UVB-irradiated skin damage (increases of skin thickness and pigmentation, and reduction of skin elasticity). Furthermore, Red Ginseng extract inhibited the increases of epidermis and corium thickness induced by UVB irradiation. Red Ginseng extract inhibited the increase of skin TGF-beta1 content induced by UVB irradiation. These findings suggest that the protective action of Red Ginseng extract against UVB-irradiated skin ageing may be due partly to an inhibition of the increase of skin TGF-beta1 induced by UVB irradiation. In conclusion, the oral administration of Red Ginseng extract may be useful as a health supplement for protection against photoageing.

Fermenting Red Ginseng Enhances Its Safety and Efficacy as a Novel Skin Care Anti-Aging Ingredient: In Vitro and Animal Study

“…Recently, RG was studied for cosmetic applications and as a cosmeceutical ingredient. [13][14][15]41,42 Some researchers have studied the fermentation of RG as a way to improve its biological activity. 43,44 Bae et al 43 reported that orally administered RG extract did not significantly protect against ischemicareperfusion brain injury, whereas fermented RG did.…”

“…Ginsenosides can induce antioxidant enzymes, such as superoxide dismutase and catalase, which are important for maintaining cell viability. 11 Many previous studies have reported that P. ginseng has anti-wrinkle effects, 12 protects against ultraviolet radiation-induced skin aging, 13,14 and has anti-melanogenesis effects. 15 Furthermore, it was reported that ginseng has immunostimulating activity.…”

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

“…ginseng has been shown to possess a wide range of biological and pharmacological activities and is used as a general tonic in traditional oriental medicine to increase vitality, health, and longevity, especially in older persons. Previous research has reported that ginseng has several beneficial effects on human and animal skin [3][4][5][6][7]. Kim et al [36] reported that topical applications of total ginseng saponins (10 pg or 100 ng/mouse) and ginsenoside Rb1 (100 fg, 10 pg, or 1 ng/mouse) isolated from red ginseng significantly inhibited increases in skin thickness and wrinkle formation and reduced skin elasticity induced by long-term UVB irradiation.…”

Stimulatory Effect of Dietary Red Ginseng on Epidermal Hydration and Ceramide Levels in Ultraviolet-Irradiated Hairless Mice

“…14 The phenylpropanoid component of cinnamic acid has also been reported to exhibit a tyrosinase inhibitory effect and depigmenting activity in UVB-induced hyperpigmentation of the brown guinea pig. Recently, oral supplementation of red ginseng extracts (20 or 60 mg=kg of body weight, twice daily) was shown to inhibit the clinical damages such as epidermal hyperplasia, pigmentation, and wrinkles in UVB-irradiated skin, 36 but little is known about the effect of ginseng extracts on epidermal hydration or facilitating ceramide accumulation in epidermis.…”