Effects of recombinant porcine somatotropin (rpST) on joint cartilage and axial bones in growing and finishing pigs

He, Ping; Aherne, F. X.; Nam, Doo Seok; Nakano, T.; Schaefer, A. L.; Thompson, James R.

doi:10.4141/cjas94-036

Cited by 1 publication

(1 citation statement)

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“…There are a number of conflicting reports documenting either increased or decreased levels of general PGs, or individual PG components of the extracellular matrix in OC. However, changes were restricted to the growth cartilage and were either unchanged due to the absence of lesions or not determined in the articular cartilage of the joints examined [5,17,18,33]. Nakano et al [31] concluded that biochemical changes in PGs only occur in severely affected joint cartilage, and not in cartilage with early OC/OA.…”

Section: Discussionmentioning

confidence: 99%

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D₃

Jefferies

Farquharson

Thomson³

et al. 2002

Vet. Res.

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-Osteochondrosis/osteoarthrosis (OC/OA) are common terms for various joint pathologies that occur in pigs. Pathologies that may contribute to these disorders have been described, but the primary cause(s) remain unknown. We hypothesised that as OC has some similarities to dyschondroplasia, which involves a failure of growth plate chondrocytes to fully differentiate and hypertrophy, treatment with 25-hydroxyvitamin D 3 (25-D) might reduce the incidence and/or severity of lesions in pigs, as it does in chickens with dyschondroplasia. Control pigs were fed a commercial diet ad libitum. In the treated group this diet was supplemented with 25-D at 0.1mg/kg. Ten pigs from each of the control and treated groups were sampled at 7, 12, 16 and 21 weeks. Treatment with 25-D had no effect on the incidence or severity of OC/OA lesions. Cartilage dry weight, total collagen content and proteoglycan content, and plasma levels of total calcium, inorganic phosphorous, vitamin C, insuline-like growth factor-I, parathyroid hormone and tumour necrosis factor alpha were unaffected by treatment. In addition, none of these parameters were correlated with the incidence or severity of OC/OA lesions. The mRNA expression levels of 21 out of 23 genes assayed by RT-PCR were unaltered in articular cartilage from OA lesion samples as compared to normal articular cartilage. However, collagen type II was reduced and collagen type X increased in OA lesion and near lesion samples. These results suggest that OA in pigs may share some features of osteoarthritis in other mammalian species. Ostéo-chondrite et arthrose (OC/AR) sont des termes courants désignant les diverses pathologies des articulations survenant chez le porc. Les maladies pouvant contribuer à ces troubles ont été décrites, mais les causes premières demeurent inconnues. Nous avons fait l'hypothèse que, puisque l'ostéochon-drite a quelques similarités avec la dyschondroplasie, qui entraîne une incapacité de la plaque endochondriale à se différencier et à s'hypertrophier, le traitement par la 25-hydroxyvitamine D 3 (25-D) pourrait réduire l'incidence et/ou la sévérité des lésions chez le porc, comme elle le fait chez les poulets atteints de dyschondroplasie. Des porcs témoins ont été nourris à volonté par des rations commerciales. Dans le groupe des porcs traités, cette ration a été complétée par de la 25-D à 0,1 mg/kg. Dix porcs provenant de chaque groupe (témoin et traité) ont été examinés aux semaines 7, 12, 16 et 21. Le traitement par la 25-D n'a eu aucun effet sur l'incidence ou la sévérité des lésions OC/AR. Le poids sec des cartilages, le contenu total en collagène et en protéoglycanes, et les taux plasmatiques en calcium total, en phosphore inorganique, en vitamine C, en facteur de croissance proche de l'insuline-I (IGF-I), en hormone parathyroïdienne, et en facteur de nécrose des tumeurs-α (TNFα), n'ont pas été affectés par le traitement. De plus, aucun de ces paramètres n'était corrélé à l'incidence ou à la sévéri-té des lésions OC/AR. Les niveaux d'expression de l'ARNm...

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Section: Discussionmentioning

confidence: 99%

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D₃

Jefferies

Farquharson

Thomson³

et al. 2002

Vet. Res.

View full text Add to dashboard Cite

show abstract

Effects of recombinant porcine somatotropin (rpST) on joint cartilage and axial bones in growing and finishing pigs

Cited by 1 publication

References 23 publications

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D₃

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D₃

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Effects of recombinant porcine somatotropin (rpST) on joint cartilage and axial bones in growing and finishing pigs

Cited by 1 publication

References 23 publications

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D3

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D3

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Resources

About

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D₃

Differences in metabolic parameters and gene expression related to Osteochondrosis/Osteoarthrosis in pigs fed 25-hydroxyvitamin D₃