Effects of raloxifene hydrochloride on bone mineral density and serum lipids in Kuwaiti postmenopausal women with osteoporosis

Abdelazim, Ibrahim A.; Faza, Mohannad Abu; Ayash, Hany Mohammed

doi:10.4103/2278-960x.153518

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Bone mesenchymal stem cells (BMSCs) produce osteogenic factors and angiogenic growth factors, which contribute to bone formation, indicating that BMSCs have direct osteogenic effects 3) . Several studies conducted extensive research on the intervention of BMSCs and other drugs to treat osteoporosis [4][5][6][7][8] . Takada et al 9) showed that BMSC transplantation restores the balance between osteoclasts and osteoblasts, improves the quantity and quality of bone tissue cells, and increases the bone density in the area, concluding that BMSC transplantation can be used to treat osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

“…Wang et al 11) investigated re-construction of osteoporotic rat femur using cultured BMSCs and calcium alginate gel mixture intervention and showed increasing trabecular bone density and strength. Previous studies [5][6][7][8][9] , however, did not investigate the effect of BMSCs and alendronate sodium tablets (ASTs) on viscoelasticity properties of the bone in an osteoporotic animal model. The authors hypothesized that stress relaxation, creep mechanical properties, bone mineral density (BMD), and serum bone metabolic markers exhibit changes in an osteoporotic animal model.…”

Section: Introductionmentioning

confidence: 99%

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Bone Viscoelastic Properties in an Animal Model with Osteoporosis after BMSC-Alendronate Sodium Intervention

Piao

Ding

Kong

2019

J. Hard Tissue Biology.

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This study aimed to test stress relaxation and creep of the femur in osteoporotic rats after bone mesenchymal stem cell (BMSC) intervention and to provide a viscoelastic basis for the prevention and treatment of osteoporosis. The osteoporotic animal models prepared by ovariectomy were intervened with BMSCs and alendronate sodium tablets (ASTs), respectively, for 30 days, and then compared for serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), estradiol (E2), estrogen receptor (ER), superoxide dismutase (SOD), and malondialdehyde (MDA) levels, as well as for stress relaxation, creep, and bone mineral density (BMD). BMD and Ca, ALP, E2, ER, and SOD levels, as well as 7200 s stress reduction and 7200 s strain increase, were statistically higher in BMSC group than in MOD and AST groups (p < 0.05). However, P and MDA levels in BMSC group were lower than those in MOD and AST groups. BMSC intervention can improve bone quality and restore bone viscoelasticity in osteoporotic rat models.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bone Viscoelastic Properties in an Animal Model with Osteoporosis after BMSC-Alendronate Sodium Intervention

Piao

Ding

Kong

2019

J. Hard Tissue Biology.

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Comparison of bone biomechanical properties after bone marrow mesenchymal stem cell or alendronate treatment in an osteoporotic animal model

Piao

Ding

Kong

2019

Biomedical Engineering / Biomedizinische Technik

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The aim of this study was to explore the effects of bone marrow mesenchymal stem cells (BMMSCs) and alendronate sodium (ALN) intervention on osteoporosis (OP). Sixty-eight 6-month-old healthy female Sprague Dawley (SD) rats were used to generate an OP model by removal of the ovaries. After 12 weeks, rats were treated with BMMSCs (BMMSC group) or ALN (ALN group) for 5 weeks. Serum type I collagen C terminal peptide (CTX_1), procollagen type I N-terminal propeptide (PINP), and bone alkaline phosphatase (BALP) were tested along with the femur bone density and other properties, including bone mineral density (BMD), BALP, percent trabecular area (BV/TV), trabecular thickness (Tb.Th), trabecular number (TbN), maximum load, maximum stress, maximum strain, and elastic modulus. BMD, BALP, BV/TV, Tb.Th, TbN, maximum load, maximum stress, maximum strain, and elastic modulus values were higher in the BMMSC group versus the ALN group relative to the control group (p < 0.05); CTX_1, PINP, trabecular separation (Tb.Sp), and osteoclast number (OC.N) were lowest in the BMMSC group versus the ALN group relative to the control group (p < 0.05). Both BMMSCs and ALN could improve the metabolic function and bone quality in osteoporotic mice while restoring the strength and toughness of bones. The intervention effects of BMMSCs are better than ALN in this model.

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Effects of raloxifene hydrochloride on bone mineral density and serum lipids in Kuwaiti postmenopausal women with osteoporosis

Cited by 2 publications

References 15 publications

Bone Viscoelastic Properties in an Animal Model with Osteoporosis after BMSC-Alendronate Sodium Intervention

Bone Viscoelastic Properties in an Animal Model with Osteoporosis after BMSC-Alendronate Sodium Intervention

Comparison of bone biomechanical properties after bone marrow mesenchymal stem cell or alendronate treatment in an osteoporotic animal model

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