Bone Viscoelastic Properties in an Animal Model with Osteoporosis after BMSC-Alendronate Sodium Intervention

Abstract

This study aimed to test stress relaxation and creep of the femur in osteoporotic rats after bone mesenchymal stem cell (BMSC) intervention and to provide a viscoelastic basis for the prevention and treatment of osteoporosis. The osteoporotic animal models prepared by ovariectomy were intervened with BMSCs and alendronate sodium tablets (ASTs), respectively, for 30 days, and then compared for serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), estradiol (E2), estrogen receptor (ER), superoxide dismutase (SOD), and malondialdehyde (MDA) levels, as well as for stress relaxation, creep, and bone mineral density (BMD). BMD and Ca, ALP, E2, ER, and SOD levels, as well as 7200 s stress reduction and 7200 s strain increase, were statistically higher in BMSC group than in MOD and AST groups (p < 0.05). However, P and MDA levels in BMSC group were lower than those in MOD and AST groups. BMSC intervention can improve bone quality and restore bone viscoelasticity in osteoporotic rat models.