Effects of radiotherapy on different histopathological types of rectal carcinoma

Şengül, Neriman; Wexner, Steven D.; Woodhouse, Sherry; Arrigain, Susana; Xu, Meng; Larach, J. A.; Ahn, Byung-Kwon; Weiss, E. G.; Nogueras, Juan J.; Berho, Mariana

doi:10.1111/j.1463-1318.2005.00934.x

Cited by 62 publications

(50 citation statements)

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“…In this study, the survival data were collected from various research, through meta-analysis, the HR value was 1.06 (CI: 1.04-1.08), suggesting the prognosis was poor in mucinous adenocarcinoma patients, although the difference of prognosis was not obvious, the HR value was only 1.06, there were still significant difference (P<0.001); therefore, we believe that mucinous adenocarcinoma is an independent prognostic risk factor for colorectal cancer. This result may be associated with reducing the sensitivity of radiotherapy and chemotherapy by mucinous adenocarcinoma (Negri et al, 2005;Sengul et al, 2006). We should pay more attention to the mucinous adenocarcinoma patients, the patients who were confirmed should be performed radical resection, and expanding the dissection range of lymph node, these organs which have been infiltrated should be performed resection too.…”

Section: Discussionmentioning

confidence: 99%

“…However, some other findings showed that mucinous adenocarcinoma was an independent prognostic risk factor (Kanemitsu et al, 2003;Catalano et al, 2009;Ghabeljoo et al, 2011). Some studies showed that mucinous adenocarcinoma might reduce the sensitivity of radiotherapy and chemotherapy in recent years (Negri et al, 2005;Sengul et al, 2006). At present, there are few studies about mucinous adenocarcinoma in China, and most studies suggested that the patients with mucinous adenocarcinoma had late stage and poor prognosis (Songqing et al, 2002;Miao et al, 2005;Safaee et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

Chen¹,

Tang²,

Xiang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumor patients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic features of colorectal tumors. Methods: 30 individual case-control studies were finally included into this meta-analysis, involving a total of 444,489 cancer cases and 45,050 mucinous adenocarcinomas, of relations with TNM staging and prognostic features. Results: Compared to non-mucinous adenocarcinoma patients, the TNM IV stage accounted for a larger percentage of mucinous adenocarcinomas (OR=1.48, 95%CI 1.28-1.71, POR<0.001) and the prognosis was significantly poor (HR=1.06, 95%CI 1.04-1.08, P<0.001). After heterogeneity testing, the results was similar to the holistic approach outcome (HR=1.48, 95%CI 1.35-1.62, P<0.001). Conclusion: Compared to patients with non-mucinous adenocarcinomas, mucinous adenocarcinoma patients with later TNM staging make up a big percentage, and mucinous adenocarcinoma is an independent risk factor for poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

Chen¹,

Tang²,

Xiang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…In some of the patients, however, MLs are induced by nCRT in rectal cancer tissue (5)(6)(7)(8)(9)(10)(11)(12). In patients who receive nCRT, the incidence of mucinous carcinoma is relatively high, ranging from 13% to 24% (6,8,11).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with mucinous carcinoma have been reported to have a poor response to nCRT, as well as poor outcomes. In some patients, however, nCRT may induce the formation of mucin lakes (MLs) in rectal cancer tissue (5)(6)(7)(8)(9)(10)(11)(12). The ability to determine whether MLs are induced or originally exist in resected specimens would be of great clinical significance.…”

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confidence: 99%

Chemoradiotherapy-induced Changes in Mucinous Components in Rectal Cancer Tissue: Evaluation on High Iron Diamine-alcian Blue and Mucin 1 Staining

et al. 2018

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Abstract. Background Total mesorectal excision (TME) after neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for rectal cancer (1-4). Patients with mucinous carcinoma have been reported to have a poor response to nCRT, as well as poor outcomes. In some patients, however, nCRT may induce the formation of mucin lakes (MLs) in rectal cancer tissue (5-12). The ability to determine whether MLs are induced or originally exist in resected specimens would be of great clinical significance.Sialomucin and sulphomucin are included in intracytoplasmic mucin of cancer cells and MLs in patients with colorectal cancer and can be identified by high iron diamine-Alcian blue (HID-AB) staining (13). Mucin 1 (MUC1), a transmembrane mucin and a membrane-bound glycoprotein, exists in cancer cells and in MLs in colorectal cancer tissue and has been reported to be related to outcomes (14-17).HID-AB staining and MUC1 immunohistochemical staining was, therefore, performed in resected specimens of rectal cancer obtained from patients who received nCRT and those who did not, to evaluate mucinous components in cancer cells and MLs in cancer tissue and examine whether nCRT induces changes in mucinous components. Patients and MethodsSubjects. From 2005 through 2015, a total of 293 patients with rectal cancer underwent curative surgery. Among the 205 patients who received nCRT, the ML formation which occupied at least 20% of the area of the maximum cut surface of the resected specimens was found in 20 patients. These patients were designated as the CRT-MC group. Among the 88 patients who did not receive CRT, 9 patients were histologically diagnosed with mucinous carcinoma on the resected specimens in which ML formation was remarkable (non-CRT-MC group), and 18 patients were diagnosed with well-or moderately differentiated adenocarcinoma but had apparent ML formation in less than 50% of the area ratios of the tumors. These patients were designated as the non-CRT-AC group. A total of 47 patients were studied. This study was approved by the institutional review board of our University (17R-238), and all patients gave their written informed consent.HID-AB staining, MUC1 staining, and evaluations. To perform HID-AB staining, the sections were deparaffinized and then stained with HID solution, prepared using N, N-dimethyl-m-phenylenediamine dihydrochloride (120 mg) and N,N-dimethyl-p-phenylenediamine 4783

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“…None of the mucinous tumour achieved complete response, but almost half were down-staged by one stage. Sengul et al [40] reported a statistically significant difference in tumour regression grade (TRG) between the two subtypes and a much smaller decrease in T and N staging. However, only 16 patients were studied and the small numbers may account for the results.…”

Section: Radiological Diagnosis and Measuring Responsementioning

confidence: 99%

Mucinous carcinoma of the rectum: a distinct clinicopathological entity

Chand

Swift

et al. 2013

Tech Coloproctol

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Purpose The definition of mucinous tumours relies on quantification of the amount of mucus produced by neoplastic cells within the rectum. This has changed over the years to include varying degrees of mucin production. The inconsistency of diagnosis has led to conflicting reports in the literature regarding clinical outcomes and treatment response. A universally accepted definition and improved imaging and surgical techniques in the last decade are now challenging the traditional view of these tumours. The aim of this review was to present the current evidence on the clinicopathological characteristics of mucinous tumours of the rectum. Methods A systematic review was conducted using Preferred Reporting for Systematic Reviews and Meta-Analyses guidelines. A literature search was performed using the Ovid SP to search both EMBASE and MEDLINE databases, Google Scholar and PubMed to find all studies relating to mucinous carcinoma of the rectum. The search dates were between 1 January 1965 and 1 March 2013. Results Mucinous tumours comprise 5-20 % of all rectal cancers and commonly present at a more advanced stage and in younger patients. They are readily identified on MRI, and the diagnosis is confirmed on histological analysis, demonstrating more than 50 % of extracellular mucin within the tumour complex. They carry an overall worse prognosis compared to adenocarcinoma of the same stage. The response to oncological treatment remains controversial. Conclusion Mucinous tumours of the rectum are less well understood than non-mucinous adenocarcinoma. This is due to the inconsistent histopathological definitions of the past making comparison of clinical outcome data difficult. They remain challenging to treat and are associated with a poor prognosis. A universally accepted definition and the role of imaging techniques such as MRI to accurately detect mucinous tumours are likely to lead to a better understanding of these cancers.

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Effects of radiotherapy on different histopathological types of rectal carcinoma

Abstract: Mucinous carcinoma was associated with a lower response to pre-operative chemo-radiotherapy in this group of rectal carcinoma patients. Further studies are needed to determine its prognostic value.

Cited by 62 publications

References 40 publications

TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

Chemoradiotherapy-induced Changes in Mucinous Components in Rectal Cancer Tissue: Evaluation on High Iron Diamine-alcian Blue and Mucin 1 Staining

Mucinous carcinoma of the rectum: a distinct clinicopathological entity

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