Effects of radiofrequency procedure on hypertrophic scar due to burns

Pinheiro, Nanci Mendes; Melo, Poliana; Crema, Virgínia Oliveira; Mendonça, A.C.

doi:10.1111/jdv.12388

Cited by 9 publications

(5 citation statements)

References 9 publications

(16 reference statements)

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“…Thus, electrical therapies with degenerate waves have shown an improvement in pain and itching, as well as a reduction in the formation of excess collagen in keloids [ 29 ]. In RF-based therapies, treatment of hypertrophic scars with moderate thermal increases (below 40 °C) generated by monopolar radiofrequency induces remodeling of collagen fibers, whether applied as a single therapy [ 14 ] or in association with negative pressure [ 18 ]. Other RF therapies have also shown changes in the morphology or production of collagen fiber [ 15 ] or a reduction in the amount of collagen I, collagen III, and TGF-β1 in scars, when RF is combined with pulsed light versus laser [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…There is experimental evidence that hyperthermia induced by radiofrequency (RF) is effective in scar or keloid regeneration treatments. In this regard, clinical evidence indicates that the application of RF [ 14 , 15 ], alone or in combination with other physical therapies such as laser [ 16 ] or ultrasound [ 17 ], can be effective for the treatment of hypertrophic and keloid scars. Thus, physical therapies induce a remodeling of the collagen derived from the denaturation of the fibers due to hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Fibrotic Effects of RF Electric Currents

Hernández-Bule

Toledano-Macías

Pérez-González

et al. 2023

IJMS

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Hypertrophic scars and keloids are two different manifestations of excessive dermal fibrosis and are caused by an alteration in the normal wound-healing process. Treatment with radiofrequency (RF)-based therapies has proven to be useful in reducing hypertrophic scars. In this study, the effect of one of these radiofrequency therapies, Capacitive Resistive Electrical Transfer Therapy (CRET) on biomarkers of skin fibrosis was investigated. For this, in cultures of human myofibroblasts treated with CRET therapy or sham-treated, proliferation (XTT Assay), apoptosis (TUNEL Assay), and cell migration (Wound Closure Assay) were analyzed. Furthermore, in these cultures the expression and/or localization of extracellular matrix proteins such as α-SMA, Col I, Col III (immunofluorescence), metalloproteinases MMP1 and MMP9, MAP kinase ERK1/2, and the transcription factor NFκB were also investigated (immunoblot). The results have revealed that CRET decreases the expression of extracellular matrix proteins, modifies the expression of the metalloproteinase MMP9, and reduces the activation of NFκB with respect to controls, suggesting that this therapy could be useful for the treatment of fibrotic pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Fibrotic Effects of RF Electric Currents

Hernández-Bule

Toledano-Macías

Pérez-González

et al. 2023

IJMS

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“… 2 3 4 5 6 We transformed the effects of ESWT on hypertrophic scars into the clinical results as POSAS scores, and most of the POSAS subscales were significantly improved after treatment. Apart from the previous studies, which included only the hypertrophic scars following burn wounds, 4 8 15 the current study also included the various etiologies of hypertrophic scars to extend the indications of using ESWT in other causes of hypertrophic scars.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it also stimulates fibroblasts, which are mechanoresponsive cells and play a role in remodeling of the extracellular matrix in wound healing and scars. [12][13][14][15][16][17][18][19][20] The molecular mechanism of ESWT has not yet been fully identified. However, induction of angiogenesis via stimulation of toll-like receptor 3 during ESWT was proposed in the literatures, possibly indicating the benefits of soft tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Extracorporeal Shock Wave Therapy for Hypertrophic Scars

et al. 2022

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Background Hypertrophic scars cause aesthetic concerns and negatively affect the quality of life. A gold standard treatment for hypertrophic scars has not been established due to various responses of modalities. Extracorporeal shock wave therapy (ESWT) is a noninvasive and affects scar remodeling by fibroblast regulation. This study investigated the effectiveness of ESWT for hypertrophic scars. Methods Twenty-nine patients were enrolled. All patients underwent ESWT once a week for 6 consecutive weeks. Their scars were assessed using the Patient and Observer Scar Assessment Scale (POSAS), erythema index, melanin index, and scar pliability before treatment and again 4 weeks after treatment completion. Results Thirty-four hypertrophic scars in this study had persisted for between 6 months and 30 years. Most scars developed after surgical incision (55.88%). The chest and upper extremities were the predominant areas of occurrence (35.29% each). Most of the POSAS subscales and total scores were significantly improved 4 weeks after treatment (p < 0.05). Furthermore, the pain, itching, and pigmentation subscale were improved. The pliability, melanin index, and erythema index were also improved, but without significance. The patients were satisfied with the results and symptoms alleviation, although subjective score changes were insignificant. No serious adverse events were found. The patients reported pruritus in 62.5% and good pain tolerance in 37.5%. Subgroup analyses found no differences in scar etiologies or properties at different parts of the body. Conclusion The ESWT is a modality for hypertrophic scar treatment with promising results. Most of POSAS subscales were significantly improved.

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