Anti-Fibrotic Effects of RF Electric Currents

Hernández-Bule, María Luisa; Toledano-Macías, Elena; Pérez-González, Luis Alfonso; Martínez-Pascual, Miryam; Fernández‐Guarino, M.

doi:10.3390/ijms241310986

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Additionally, Tecar therapy action was assessed on biomarkers of skin fibrosis using human myofibroblast cultures. Results indicated that it decreased the expression of extracellular matrix proteins, altered metalloproteinase 9 expression, and reduced nuclear factor kappa-light-chain-enhancer of activated B cells activation compared to controls, suggesting its potential efficacy in treating fibrotic conditions [163].…”

Section: Tecar Therapymentioning

confidence: 99%

Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

Lippi,

Ferrillo,

Losco

et al. 2024

Medicina

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Although rehabilitation medicine emphasizes a holistic health approach, there is still a large gap of knowledge about potential interventions aimed at improving overall wellbeing through cosmetic interventions. Therefore, this narrative review investigates the role of different rehabilitative techniques in enhancing aesthetics, quality of life, and psychosocial wellbeing for patients with disabilities. The study follows the SANRA framework quality criteria for a narrative review. Literature searches across PubMed/Medline, Web of Science, and Scopus identified articles focusing on rehabilitation strategies within the aesthetic rehabilitation domain. The review identified evidence supporting injection procedures, such as Botulinum Toxin, Platelet-Rich Plasma, Hyaluronic Acid, Ozone, and Carboxytherapy, and assessing their applications in several disabling disorders. Additionally, physical therapies like Extracorporeal Shock Wave Therapy, Laser Therapy, Microcurrent Therapy, Tecar Therapy, and physical exercises were explored for their impact on cutaneous microcirculation, cellulite treatment, wound healing, and scar appearance improvement. Lastly, the manuscript underlines the role of manual therapy techniques in addressing both physical discomfort and aesthetic concerns, discussing their effectiveness in adipose tissue therapy, scar tissue mobilization, and regional fat thickness reduction. Taken together, this review emphasizes the role of a multidisciplinary approach, aiming to provide valuable insights into potential benefits for both functional and aesthetic outcomes.

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Section: Tecar Therapymentioning

confidence: 99%

Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

Lippi,

Ferrillo,

Losco

et al. 2024

Medicina

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Novel needle‐type electrocoagulation and combination pharmacotherapy: Basic and clinical studies on efficacy and safety in treating keloids

Zhao,

Zhai,

et al. 2024

J of Cosmetic Dermatology

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Background and AimKeloids cannot be effectively treated using monotherapy regimens. This study aimed to evaluate the efficacy and safety of ablation (a novel needle‐assisted electrocoagulation technique) combined with pharmacotherapy (corticosteroid and 5‐fluorouracil [5‐FU] injections) in removing keloids and to investigate the underlying biological mechanisms.MethodsThe effects of energy consumption and duration of needle‐assisted electrocoagulation on the ablation zone were tested in porcine liver tissue, which simulates human skin. The regulatory effects of ablation combined with pharmacotherapy on collagen deposition, cell proliferation, and angiogenesis were analyzed in a keloid‐bearing nude mouse model in vivo. In a clinical trial involving six patients with keloids, the Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) scores were graded before treatment and 1 month after one cycle of ablation combined with corticosteroid and 5‐FU therapy.ResultsHigher energy consumption and longer duration of electrocoagulation resulted in a larger ablation zone and higher surface temperature. Ablation combined with pharmacotherapy significantly reduced keloid volume in nude mice, upregulated MMP‐1 and MMP‐3, downregulated COL I and COL III, and inhibited angiogenesis and proliferation. This combination also significantly reduced the VSS and POSAS scores in patients with keloids after treatment without any obvious adverse events.ConclusionOur findings show that electroablation combined with pharmacotherapy effectively reduces keloid volume by inhibiting collagen deposition, angiogenesis, and cell proliferation. Thus, this novel combination may serve as a safe therapeutic approach for keloid removal.

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Anti-Fibrotic Effects of RF Electric Currents

Cited by 2 publications

References 48 publications

Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

Novel needle‐type electrocoagulation and combination pharmacotherapy: Basic and clinical studies on efficacy and safety in treating keloids

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