Effects of quercetin and surgicel for preventing adhesions after gynecological surgery: A rat uterine horn model

Güney, Gürhan; Kaya, Cihan; Oto, Gökhan; Yıldırım, Serkan; Özdemir, Hülya; Tokmak, Aytekin

doi:10.1111/jog.13185

Cited by 10 publications

(6 citation statements)

References 19 publications

(47 reference statements)

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“…This is a simple, effective, and reproducible technique for hemostasis during emergency TAR surgeries for acute aortic dissection with FET. Hydrofit ® sealant is reinforced with Surgicel ® , since Surgicel ® is considered to be capable of holding or containing water or blood …”

Section: Resultsmentioning

confidence: 99%

Enhanced hemostasis with a sealant consisting of Hydrofit and Surgicel

2017

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Section: Resultsmentioning

confidence: 99%

Enhanced hemostasis with a sealant consisting of Hydrofit and Surgicel

2017

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“…so far, many surgical methods have been described aiming at the prevention of excessive creation of peritoneal adhesions (folding of the intestine wall, splinting of the intestine and leaving the peritoneum open in the post-operative course), but these methods result in the necessity to perform further operational interventiona [15,16]. This is why the avoidance of a lesion of the peritoneum during an operation is considered to be the most efficient method of preventing the creation of post--operative adhesions [1,17].…”

Section: Discussionmentioning

confidence: 99%

“…They occur in about 5-14% of surgical patients. abdominal adhesions very frequently occur after operations executed in the lower part of the abdominal cavity (surgical interventions affecting intestines, laparoscopy, gynecological operations) [1]. sometimes peritoneal adhesions do not cause any complications, yet in many cases, the presence of adhesions causes persistent or recurrent abdominal pains.…”

Section: Introductionmentioning

confidence: 99%

Physical possibilities in the treatment of chronic abdominal pain in patients with peritoneal adhesions

Pasek¹,

Senejko²,

Cieślar³

2019

fmpcr

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Background. The most intensive pains suffered by patients after surgical interventions are caused by post-operative peritoneal adhesions, which are incorrect connective tissue connections formed on or among internal organs and tissues in the abdominal cavity. These adhesion-related pains are resistant to analgesic treatment and often persist for many years. Objectives. in this trial, the estimation of the efficacy of combined treatment with the use of two variable magnetic field related therapeutic methods (magnetotherapy and magnetostimulation) in the treatment of 119 patients with chronic abdominal pains caused by numerous post-operative peritoneal adhesions was performed. Material and methods. 67 patients from the examined group were subjected to two series of 20 daily procedures of exposure to variable magnetic fields in the form of magnetotherapy and magnetostimulation, while 52 patients from the comparison group were subjected to sham exposure, during which no magnetic field was generated in the applicators. Prior to the therapeutic cycle and after its completion, the assessment of pain intensity, with the use of the Visual analogue scale (Vas), and subjective estimation of quality of life, by means of the euroQol scale, were performed. Results. in patients from the examined group, a significant decrease in pain intensity, according to the Vas, and a significant improvement of life quality level, on the euroQol scale, in comparison to initial values, was achieved (8.0 ± 1.1 vs 2.3 ± 1.0 points, and 30.2 ± 14.1 vs 86.2 ± 8.5 points, respectively (p < 0.05); while in the control group, no statistically significant changes of the estimated parameters were observed. Conclusions. Magnetotherapy and magnetostimulation are efficient therapeutic methods in the case of patients with long-lasting abdominal pain related to peritoneal adhesions, enabling an improvement in their life quality (regardless of gender and age). Taking into account that magnetotherapy and magnetostimulation are not applicable in primary care, family doctors should consider a consultation with a physical therapy specialist in order to prescribe a cycle of physical treatment with the use of these methods in the case of such patients with drug-resistant abdominal pain caused by diagnosed postoperative peritoneal adhesions.

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“…As described by Kaya et al [21] five standard lesions were made on the antimesenteric side of each uterine horn with a 10-Watt bipolar cautery [22,23]. The same surgical procedure was performed in all rats.…”

Section: Methodsmentioning

confidence: 99%

“…After the animals recovered from surgery, they were housed separately under controlled temperatures of 22-28°C with 14-hour light and 10-hour dark cycles with food and water ad libitum. The surgery was limited to approximately 10 minutes for each rat to prevent the tissue from drying at room temperature [21,23]. All surgical procedures were performed by the same surgeon (N.C), who has 10 years of experience in gynecology and obstetrics, and an Obstetrics and Gynecology resident.…”

Section: Methodsmentioning

confidence: 99%

Two natural materials found to reduce adhesion formation in a rat uterine horn model

Elçi¹,

Sayan²,

Elçi³

et al. 2021

Journal of Surgery and Medicine

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Background/Aim: Post-operative pelvic adhesions cause various problems in patients, pose surgical difficulties to clinicians, and an increase in health costs. We compared the effectiveness of two natural materials, Trehalose (TRZ), Human Amnion Fluid (HAF), with oxidized regenerated cellulose (ORC) in terms of adhesion prevention after gynecological operations. Methods: In this controlled experimental study, twenty-four female Wistar Hannover rats were divided into four groups: Control, TRZ, HAF, and ORC. The control group received medication used for the surgical procedure only. 3% TRZ, cell-free HAF, and 1 cm 2 ORC (interceed®) were laid on the tissue on the antimesenteric side of each uterine horn damaged with a 10-Watt bipolar cautery. Adhesions were scored 30 days after the first surgical procedure. Results: The extent, severity, degree, total adhesion, inflammation, and fibrosis scores of the control group were significantly higher than those of the TRZ and HAF groups (P<0.05 for each). There was no significant difference between the Control and ORC groups in terms of inflammation (P=0.055), but all other parameters were significantly higher in the control group compared to the ORC group (P<0.05). The TRZ group had lower total adhesion scores (P=0.019) and histopathological scores (P=0.015, P=0.001) than the ORC group. Conclusions: TRZ and HAF may be useful in preventing pelvic adhesions.

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Effects of quercetin and surgicel for preventing adhesions after gynecological surgery: A rat uterine horn model

Abstract: Quercetin, Surgicel and quercetin + Surgicel treatment may be useful for preventing pelvic adhesions.

Cited by 10 publications

References 19 publications

Enhanced hemostasis with a sealant consisting of Hydrofit and Surgicel

Enhanced hemostasis with a sealant consisting of Hydrofit and Surgicel

Physical possibilities in the treatment of chronic abdominal pain in patients with peritoneal adhesions

Two natural materials found to reduce adhesion formation in a rat uterine horn model

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