Effects of Quercetin and Catechin on Hepatic Glutathione-S Transferase (GST), NAD(P)H Quinone Oxidoreductase 1 (NQO1), and Antioxidant Enzyme Activity Levels in Rats

Wiegand, Heike; Boesch-Saadatmandi, Christine; Regos, Ionela; Treutter, D.; Wolffram, Siegfried; Rimbach, Gerald

doi:10.1080/01635580902825621

Cited by 47 publications

(36 citation statements)

References 51 publications

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“…A study of growing rats revealed that dietary flavonoids do not affect vitamin E status (Wiegand et al 2009). Very few studies have been conducted on poultry, and they produced inconsistent results regarding the direction and range of the antioxidant effects of polyphenols in birds.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant status of blood and liver of turkeys fed diets enriched with polyunsaturated fatty acids and fruit pomaces as a source of polyphenols

Jankowski

Juśkiewicz

Zduńczyk

et al. 2016

Polish Journal of Veterinary Sciences

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It was hypothesized that dietary polyphenol-rich fruit pomaces can improve the antioxidant status of both diets and the tissues of turkeys fed such diets. Turkeys were fed diets containing a cellulose preparation (C) or 5% dried apple pomace (AP), blackcurrant pomace (BCP), strawberry pomace (SP) and seedless strawberry pomace (SSP). Blood and liver biochemical parameters were determined in 7 birds from each experimental group slaughtered at 15 weeks of age, after 5 weeks of feeding diets containing soybean oil and linseed oil (approx. 1:1 ratio). Dietary linseed oil added to diets at 2.5% lowered the n-6/n-3 PUFA ratio from approx. 7:1 to below 2:1, thus reducing the antioxidant properties of diets measured using DPPH, ABTS and photo-chemiluminescence assays, compared with diets containing only soybean oil and administered to birds in the first phase of feeding. Fruit pomaces, in particular SSP with the highest polyphenol content (32.81 g/kg) and the highest antioxidant activity (256.4 μM Trolox/g), increased the antioxidant capacity of turkey diets. In comparison with the control group, the dietary treatments with fruit pomaces improved blood antioxidant parameters, including catalase activity (groups AP and BCP), the total antioxidant capacity of hydrophilic (group AP) and lipophilic (groups AP, SP, and SSP) compounds, peroxide levels (groups AP and SSP) and antioxidant capacity measured by the FRAP (ferric reducing antioxidant power of plasma) assay (groups AP, BCP and SSP). Significantly lower concentrations of both vitamin E and thiobarbituric acid reactive substances (TBARS) were noted in the livers of turkeys fed all diets with dried fruit pomaces.

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Section: Discussionmentioning

confidence: 99%

Antioxidant status of blood and liver of turkeys fed diets enriched with polyunsaturated fatty acids and fruit pomaces as a source of polyphenols

Jankowski

Juśkiewicz

Zduńczyk

et al. 2016

Polish Journal of Veterinary Sciences

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“…11 in turn may affect the ability of the organism to detoxify endogenous and exogenous xenobiotics (98).…”

Section: Interactions Of Flavonoids With Cyp a Number Of Studies Havementioning

confidence: 99%

Which Sources of Flavonoids: Complex Diets or Dietary Supplements?

Egert

Rimbach

2011

Advances in Nutrition

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178

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There is increasing interest in the potential health benefits of dietary flavonoids. Fruits and vegetables, tea, and cocoa are rich natural sources of flavonoids. Epidemiological studies have indicated that consumption of these foods is likely to be associated with a reduced risk of cardiovascular disease, but the etiology of this benefit is not yet clearly defined. Furthermore, in some acute interventions, a positive effect of tea and cocoa on vascular function has been reported. An alternative source of flavonoids is dietary supplements, which have become increasingly popular in the recent past. In this context, it needs to be critically evaluated whether vascular health-promoting and other positive properties of flavonoid-rich diets can be replaced by purified flavonoids as dietary supplements. Plant sources of flavonoids contain a complex mixture of secondary plant metabolites and not only flavonoids per se. This complex mixture of secondary plant metabolites cannot be simply exchanged by single purified compounds as dietary supplements. If flavonoids are given as dietary supplements, toxicity issues as well as nutrient drug interactions need to be taken into account. Purified flavonoids given in high doses as dietary supplements may affect trace element, folate, and vitamin C status. Furthermore, they may exhibit antithyroid and goitrogenic activities. In this review article, the available literature on the safety issues surrounding high dose supplemental flavonoid consumption has been summarized.

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“…Same as in our study, the lowered NQO activity and unchanged activity of GPx, CAT, SOD in liver were revealed in rats fed semisynthetic diets enriched with catechin (2 g/kg) for 3 weeks [Wiegand et al, 2009]. NQO catalyzes two-electron reduction of quinones, thereby preventing one-electron reduction of quinones that would cause redox cycling with generation of superoxide.…”

Section: Discussionmentioning

confidence: 84%

“…As antioxidant enzymes keep redox balance and protect organism against reactive oxygen species (ROS), their modulation by tea catechins might have important consequences. Several studies, including our previous study, have shown that green tea polyphenols are able to modulate the expression and/or activity of antioxidant enzymes, such as glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), NAD(P)H:quinone oxidoreductase (NQO) and glutathione S-transferase (GST) in healthy lean mice or rats [Khan et al, 1992;Na & Surh, 2008;Wiegand et al, 2009;Bartikova et al, 2015]. However, there are only limited information about the effect of green tea on antioxidant status of obese animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

Bártíková¹,

Boušová²,

Matoušková³

et al. 2017

Pol. J. Food Nutr. Sci.

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Key words: monosodium glutamate-induced obesity, catechins, oxidative stress, polyphenon 60Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their effi cacy in obese individuals is insuffi cient. The present study was designed to follow up the effect of defi ned and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specifi c activities of glutathione reductase and catalase and increased concentrations of malondialdehyde in blood. Specifi c activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.Unauthenticated Download Date | 5/12/18 3:35 AM

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Effects of Quercetin and Catechin on Hepatic Glutathione-S Transferase (GST), NAD(P)H Quinone Oxidoreductase 1 (NQO1), and Antioxidant Enzyme Activity Levels in Rats

Cited by 47 publications

References 51 publications

Antioxidant status of blood and liver of turkeys fed diets enriched with polyunsaturated fatty acids and fruit pomaces as a source of polyphenols

Antioxidant status of blood and liver of turkeys fed diets enriched with polyunsaturated fatty acids and fruit pomaces as a source of polyphenols

Which Sources of Flavonoids: Complex Diets or Dietary Supplements?

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice

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