Effects of Pycnogenol on cisplatin-induced optic nerve injury: an experimental study

Abstract

Pycnogenol pretreatment was highly effective in preventing augmentation of cisplatin-induced oxidative stress and inflammation in eye tissue.

Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries?

“…There are countless experimental studies about pycnogenol. In this literature, the antioxidative effects of pycnogenol have been investigated in various organs and tissues, such as the eye, brain, optic nerve, nasal mucosa, peritoneum, lymph nodes, bones, heart, aorta, kidney, liver and colon in animal models [8,[10][11][12][13][19][20][21][22][23][24]. This literature information suggests that antioxidant drugs might be beneficial in preventing CP-related uterine and ovarian toxicity.…”

“…Pycnogenol also inhibits histamine and proinflammatory cytokines and reduces allergic responses [10]. Icel et al reported that pycnogenol treatment was highly effective in preventing cisplatin-induced oxidative stress in ocular and optic nerve tissues [11].…”

Abstract Book of 6th International Brain Research School-21 and 27 June 2021, Isparta /TURKEY-http://2021.brs.org.tr

“…The etiology of the chemotherapeutic agent should be clarified in order to allow the discovery of new therapeutic drugs to modulate the chemotherapeutic agent-induced optic nerve oxidative damage. The results of recent studies indicate the involvement of chemotherapeutic agents-induced oxidative stress in the optic nerve oxidative injury in the rats (Icel et al 2018;Taşlı et al 2018;Özkaya and Nazıroğlu 2020).…”

“…The hydrogen peroxide is converted to water by the catalytic actions of catalase and glutathione peroxidase. Hence, the decrease of the antioxidants such as glutathione and glutathione peroxidase were reported in the cisplatin-induced optic nerve injury of rats, although the decreases of antioxidants are modulated by the antioxidant treatments such as curcumin, Pycnogenol, and rutin (Icel et al 2018;Taşlı et al 2018;Özkaya and Nazıroğlu 2020). In the oral presentation, I will summarize recent developments on the chemotherapeutic agents-induced oxidative injury in optic nerve.…”

Chemotherapeutic agents increase mitochondrial oxidative stress and apoptosis in optic nerve

“…If the products of oxidative stress such as superoxide radical and hydrogen peroxide will be controlled by antioxidants the cell injury in normal tissue will not be occur. Results of recent reports indicated that optic nerve injury was induced through excessive production of reactive oxygen species (ROS) in rats by chemotherapeutic agents, although ROS were scavenged by antioxidants such as pycnogenol and rutin (Icel et al 2018;Taşlı et al 2018). It seems that the chemotherapeutic agentsinduced excessive ROS production results in increased levels of lipid peroxidation as malondialdehyde and inflammation markers such as TNF-α and NF-κB levels, but decrease of glutathione and total antioxidant levels.…”