Effects of Purified Paper (Yellow) Wasp (Polistes flavus) Venom Toxins on Phosphatase Enzyme Activity in Blood Serum, Liver and Gastrocnemius Muscle Tissue of Albino Mice

Abstract

In this study biological effects of purified wasp venom toxins were evaluated on phosphatase enzyme activity in blood serum, liver and gastrocnemius muscle tissue of albino mice. A significant elevation was observed in serum acid phosphatase, alkaline phosphatase in serum, liver and gastrocnemius muscles in albino mice after injection of sub-lethal dose of purified Polistes flavus venom toxins. Polistes flavus venom toxins also cause liver ischemia and hypoxia, which resulted in increase in level of serum acid phosphatase and alkaline phosphatase, may retard the protein synthesis in tissues and release excess free amino acids into the circulation, thereby, increasing amino acid level in the serum. Both conditions clearly indicate toxic effects of venom toxins on membrane and muscle cell functions.