Effects of Proteins from Culture Medium on Surface Property of Silanes- Functionalized Magnetic Nanoparticles

Zp, Chen; Xu, Rongzheng; Zhang, Y; Gu, Ning

doi:10.1007/s11671-008-9226-1

Cited by 56 publications

(35 citation statements)

References 27 publications

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“…On the second day, the particle size and polydispersity increased due to the agglomeration of NPs. There have been several studies of the effect of serum adsorption on the behaviour of NPs in biological systems [44][45][46]. Interactions of NPs with biomolecules such as proteins may interfere with the functions of both.…”

Section: Stability Of Polymer-bound Fe 3 O 4 Nanoparticlesmentioning

confidence: 99%

Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study

Castelló

Gallardo

Busquets

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Stability Of Polymer-bound Fe 3 O 4 Nanoparticlesmentioning

confidence: 99%

Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study

Castelló

Gallardo

Busquets

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Silanes-MNPs with various functional groups had different adsorption capacity to proteins in the cell culture medium, as inferred by UV-visible spectroscopy using Coomassie blue fast staining method, about 4.8% of proteins in 10 mL cell culture medium could be adsorbed onto the surface of 1 mg NH 2 -silanes-MNPs. And compared to NH 2 -and COOH-silanes-MNPs, the amount of protein adsorbed by PEG-silanes-MNPs was negligible, indicating protein repellent property of PEG despite its low molecular weight and short chain used in this study [25].…”

Section: Protein Corona Associated With Nanoparticlesmentioning

confidence: 80%

In vitro biological effects of magnetic nanoparticles

Chen

2012

Chin. Sci. Bull.

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Magnetic nanoparticles (MNPs) have great potential for a wide use in various biomedical applications due to their unusual properties. It is critical for many applications that the biological effects of nanoparticles are studied in depth. To date, many disparate results can be found in the literature regarding nanoparticle-biological factors interactions. This review highlights recent developments in this field with particular focuses on in vitro MNPs-cell interactions. The effect of MNPs properties on cellular uptake and cytotoxicity evaluation of MNPs were discussed. Some employed methods are also included. Moreover, nanoparticle-cell interactions are mediated by the presence of proteins absorbed from biological fluids on the nanoparticle. Many questions remain on the effect of nanoparticle surface (in addition to nanoparticle size) on protein adsorption. We review papers related to this point too. The current development of magnetic nanoparticles (MNPs) requires a better understanding of its biological effects. A great deal of work has been conducted to study MNPsbiological factors interactions. Many researchers bend themselves to in vitro cell-based assessment. In this work, the current knowledge of how the in vitro cultured cells can interact with the exposed colloid MNPs is discussed as well as the effect of nanoparticle size and surface properties on cell responses. The specific cell line selected for in vitro assay is intended to model a response or phenomenon likely observed or sensitized by particles in vivo. Here, the frequent lack of consistency or predictability between in vitro models and in vivo observations, which is because of the different biological conditions particles exposed to and the changed cell phenotype against primary cell types, is out of our consideration. As we have known, cell monocultures as measured by in vitro assays rarely react in such isolated pathways in native tissues comprosed of multiple, dynamically communicative cell types that produce non-linear and correlated response to foreign materials.Adsorption of proteins onto the nanoparticle surface happens immediately after particles come in contact with a biological fluid, and it is the proteins associate with nanoparticles, leading to a protein "corona" which defines the biological identity of the particle. Here, we also try to review some current work on associated protein "corona" when nanoparticles were incubated in biological medium.

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“…Some particles are stabilized by the proteins in the cell culture media while some are aggregated by salts [116], [117], [118], [119], [120].…”

Section: Nanotoxicologymentioning

confidence: 99%

Toxicological Issues of Nanoparticles Employed in Photocatalysis

Wagner

Bloh²,

Kasper³

et al. 2011

Green

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A huge amount of different nanomaterials is nowadays on the market used for various specific applications. Some nanomaterials such as TiOHence these materials are used for many applications, e.g., for self-cleaning and antibacterial coatings on different surfaces and for the purification of wastewater where the cleaning can be induced by simple exposure to sunlight. Because of the frequent use of these nanoparticles it is important to investigate the life cycles of these nanostructured materials as well as their environmental impact and their toxicity to animals and humans.This review first gives a short overview about nanotechnology and nanotechnological products as well as about photocatalysis and semiconductors used in this field. We then discuss the need for a new technology named nanotoxicology and the problems occurring when investigating the toxic potential of nanomaterials as well as the life cycle of nanomaterials. Furthermore, we focus on the environmental impact of TiO

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Effects of Proteins from Culture Medium on Surface Property of Silanes- Functionalized Magnetic Nanoparticles

Cited by 56 publications

References 27 publications

Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study

Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study

In vitro biological effects of magnetic nanoparticles

Toxicological Issues of Nanoparticles Employed in Photocatalysis

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