Effects of protein deficiency on lipid peroxidation in the small intestine and liver of rats

Soda intake influences phenotype, antioxidants and inflammatory status in high protein-fed wistar rats

“…In this study we investigated the effect our experimental diets on malondialdehyde levels in both male and female animals. The low MDA levels in high protein diet groups confirms previous findings that protein has an inverse relationship with lipid peroxidation as previous research has shown that diets low in protein increase markers of lipid peroxidation [ 71 , 72 ].…”

Effects of a Low-Protein Diet on Plasma Amino Acid and Homocysteine Levels and Oxidative Status in Rats

“…Feoli et al [8] observed similar results in the brain of rats whose mothers were exposed to protein malnutrition (7% protein diet). Pelissier et al [25] detected a significant reduction in GSH concentration in the liver and intestine of rats submitted to protein malnutrition (6 vs. 22% casein), and also reported a greater incidence of deleterious effects such as an increase in biomarkers of lipid peroxidation in the intestine linked to protein deficiency. Prada et al [26] observed a significant reduction and increase in plasma GSH and TBARS concentration, respectively, in rats administered a protein-deficient diet (6% casein) compared to those given a control diet (17% casein) for 21 days.…”

“…While some investigators have already observed this phenomenon [8,12,25,26] , few studies have related GSH concentrations to an increase in lipid peroxidation in the liver. Hum et al [12] studied the effects of diets containing 5 different protein concentrations (0, 5, 10, 20 and 40% casein) administered to rats for 7 days.…”