Effects of protein and amino acid supplementation on muscle protein metabolism in relation to exercise

Shimomura, Yoshiharu; Kitaura, Yasuyuki; Shimomura, Noriko

doi:10.7600/jpfsm.1.219

Cited by 4 publications

(4 citation statements)

References 52 publications

(58 reference statements)

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“…There is a less degree of change (decrease) of the post supplementation mean values of the BCAA group as compared to the placebo group signifying the effectiveness of the experimental supplement in attenuating the reduction of muscle force following damaging exercises. These findings suggest a possibility of improved regulation of muscle protein metabolism following supplementation post EIMD [35,36]. Moreover, we observed an improvement in the mean values of muscle force in the subsequent day of recovery (transition from Day 2 to Day 3 values) both before and after supplementation of either BCAA or placebo, yet contrary to our hypothesis BCAA convincingly enhanced recovery after supplementation only during flexion movement of supplementation period was found to be higher than in the pre supplementation period in the BCAA group, both depicting an improved lactate threshold [23] and an augmented ventilatory response [37] post EIMD due to less muscle damage and enhanced muscle recovery following supplement consumption.…”

Section: Resultsmentioning

confidence: 75%

Effect of Chronic Supplementation of Branched Chain Amino Acids on Exercise-Induced Muscle Damage in Trained Athletes

Shenoy¹,

Dhawan²,

Sandhu³

2017

JSS

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PURPOSE: Branched Chain Amino Acids (BCAA) has been considered an important nutritional strategy to improve skeletal muscle protein turnover in many conditions especially following exercise induced muscle damage. Exercise induced muscle damage (EIMD), a phenomenon impairs muscle function and hampers athletic performance. The effects of consumption of BCAA for a chronic period (4 weeks) on EIMD in trained athletic population have never been explored. Therefore, the aim of the present study was to examine the effects of chronic consumption (4 weeks) of BCAA on indices of muscle damage elicited via a bout of damaging exercise in trained athletes. METHODS: Twenty trained males (20 road cyclists) aged 18-28 years were randomly assigned to two groups (BCAA and Placebo) (n = 10). The damaging exercise consisted of 100 consecutive drop-jumps. Biochemical markers including creatine kinase (CK), high sensitivity c reactive protein (hs-cRP) and myeloperoxidase (MPO), isometric knee muscle strength, muscle soreness, aerobic capacity (VO 2max ) and heart rate (HR) were measured. RESULTS: Differences were observed in pre-and post-supplementation periods among all the participants with mean height and weight values of 168.57 (4.5) cm and 61.74 (4.55) kg respectively as calculated by the anthropologist randomly allocated to the two groups in all tested parameters indicating the effectiveness of BCAA in attenuating muscle damage and enhancing muscle recovery with chronic consumption when compared to placebo, however in contrast to our expectations based on symptoms and our clinical judgment during the study statistically significant difference (P < 0.05) were noticed with biochemical indices only. CONCLUSION: Our findings suggest that chronic BCAA supplementation proved to be an effective meansof reducing muscle damage, enhancing muscle protein synthesis and recovery following EIMD as compared to placebo in well trained athletic population.

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Section: Resultsmentioning

confidence: 75%

Effect of Chronic Supplementation of Branched Chain Amino Acids on Exercise-Induced Muscle Damage in Trained Athletes

Shenoy¹,

Dhawan²,

Sandhu³

2017

JSS

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“…There is little information in exercise literature with respect to effects of soy protein consumption on change in isometric muscle strength after damaging bout of exercise. The possible rationale behind the decrease in reduction of muscle strength following supplementation post exercise induced muscle damage may be attributed to the regulatory function of isolated soy protein on muscle protein metabolism (38, 39). …”

Section: Discussionmentioning

confidence: 99%

Four Weeks of Supplementation With Isolated Soy Protein Attenuates Exercise-Induced Muscle Damage and Enhances Muscle Recovery in Well Trained Athletes: A Randomized Trial

2016

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BackgroundThe effects of consumption of isolated soy protein (ISP) for a chronic period (4 weeks) on exercise induced muscle damage (EIMD) in athletic population have never been explored.ObjectivesTo examine the effects of ISP on muscle damage indices elicited via a bout of damaging exercise.Patients and MethodsForty males (20 boxers, 20 cyclists) aged 18 - 28 years were randomly assigned to two groups (ISP and Placebo) (n = 20). All participants who engaged themselves in specific, regular training of 30 hours a week during the competitive season were included in the study. Participants consumed the supplement and the placebo for 4 weeks. The damaging exercise consisted of 100 consecutive drop-jumps. Pre and post supplementation readings of the criterion variables, highly sensitive C reactive protein (hs-cRP), creatine Kinase (CK), myeloperoxidase (MPO), isometric muscle strength, maximum aerobic capacity (VO2 max), heart rate (HR) and muscle soreness were obtained at baseline (Day 1), at 24 hours (Day 2) and at 48 hours (Day 3) following EIMD.ResultsDifferences were observed in pre and post supplementation values (P < 0.05) indicating the effectiveness of soy protein in attenuating muscle damage and enhancing muscle recovery.ConclusionsOur findings suggest that soy protein; a vegetable based supplement is effective, in ameliorating the negative effects of EIMD in trained athletic population.

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“…Amino acids have long been known to be prime regulators of autophagy, 53 and BCAA supplementation suppresses muscle protein breakdown 54,55 . In this study, MuRF‐1 mRNA expression in the Tr group tended to be lower than that of the DeTr group (Figure 5A) but not different from that of the DeTr + BCAA group.…”

Section: Discussionmentioning

confidence: 50%

Branched‐chain amino acid supplementation suppresses the detraining‐induced reduction of mitochondrial content in mouse skeletal muscle

et al. 2022

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Exercise training enhances oxidative capacity whereas detraining reduces mitochondrial content in skeletal muscle. The strategy to suppress the detraininginduced reduction of mitochondrial content has not been fully elucidated. As previous studies reported that branched-chain amino acid (BCAA) ingestion increased mitochondrial content in skeletal muscle, we evaluated whether BCAA supplementation could suppress the detraining-induced reduction of mitochondrial content. Six-week-old male Institute of Cancer Research (ICR) mice were randomly divided into four groups as follows: control (Con), endurance training (Tr), detraining (DeTr), and detraining with BCAA supplementation (DeTr + BCAA). Mice in Tr, DeTr, and DeTr + BCAA performed treadmill running exercises [20-30 m/min, 60 min, 5 times/week, 4 weeks]. Then, mice in DeTr and DeTr + BCAA were administered with water or BCAA [0.6 mg/g of body weight, twice daily]for 2 weeks of detraining. In whole skeletal muscle, mitochondrial enzyme activities and protein content were decreased after 2 weeks of detraining, but the reduction was suppressed by BCAA supplementation. Peroxisome proliferatoractivated receptor γ coactivator-1α (PGC-1α) protein content, a master regulator of mitochondrial biogenesis, was decreased by detraining irrespective of BCAA ingestion. Regarding mitochondrial degradation, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), a mitophagy-related protein, was significantly higher in the Tr group than in the DeTr + BCAA group, but not different from in the DeTr group. With respect to mitochondrial quality, BCAA ingestion

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Effects of protein and amino acid supplementation on muscle protein metabolism in relation to exercise

Cited by 4 publications

References 52 publications

Effect of Chronic Supplementation of Branched Chain Amino Acids on Exercise-Induced Muscle Damage in Trained Athletes

Effect of Chronic Supplementation of Branched Chain Amino Acids on Exercise-Induced Muscle Damage in Trained Athletes

Four Weeks of Supplementation With Isolated Soy Protein Attenuates Exercise-Induced Muscle Damage and Enhances Muscle Recovery in Well Trained Athletes: A Randomized Trial

Branched‐chain amino acid supplementation suppresses the detraining‐induced reduction of mitochondrial content in mouse skeletal muscle

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