Effects of Prostaglandin F2 on Pseudopregnancy and Pregnancy in Mice

Bartke, A; Merrill, Anne P.; Baker, Cyril F.

doi:10.1016/s0015-0282(16)39132-4

Cited by 29 publications

(1 citation statement)

References 13 publications

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“…It was suggested that uterus in an unknown manner controls the luteal functions (Asdell 8c Hammond 1933;Bradbury 1937;Wiltbank 8c Casida 1956;Perry Sc Rowlands 1961;Fischer 1965;Ginther et al 1966;Duby et al 1969;Orsini 1969). Exogenous PGFo" induces luteal regression, shortens pseudopregnancy and terminates preg¬ nancy in many species of animals (Gutknecht et al 1969;McCracken et al 1970;Bartke et al 1972;Chang 8c Hunt 1972;Labhsetwar 1974;Lau et al 1974;Lau et al, in press;Saksena et al, in press). Exogenous PGFo" induces luteal regression, shortens pseudopregnancy and terminates preg¬ nancy in many species of animals (Gutknecht et al 1969;McCracken et al 1970;Bartke et al 1972;Chang 8c Hunt 1972;Labhsetwar 1974;Lau et al 1974;Lau et al, in press;Saksena et al, in press).…”

mentioning

confidence: 99%

Effect of Indomethacin, an Inhibitor of Prostaglandin Biosynthesis on the Length of Pseudopregnancy in Rats and Hamsters

Lau¹,

Saksena²,

Chang³

1975

Acta Endocrinologica

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confidence: 99%

Effect of Indomethacin, an Inhibitor of Prostaglandin Biosynthesis on the Length of Pseudopregnancy in Rats and Hamsters

Lau¹,

Saksena²,

Chang³

1975

Acta Endocrinologica

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Potential Value of Plants As Sources of New Antifertility Agents I *

Farnsworth¹

1975

Journal of Pharmaceutical Sciences

208

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Teratology study with the synthetic prostaglandin ONO‐802 given intravaginally to rabbits

Petrere¹,

Humphrey²,

Sakowski³

et al. 1984

Teratog Carcinog Mutagen

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ONO-802, a synthetic E1 prostaglandin, was administered intravaginally via pessaries to Dutch belted rabbits at doses of 250, 62.5, and 12.5 micrograms/kg on days 6 through 18 of gestation. Rabbits in a vehicle control group were treated with pessaries that did not contain ONO-802 during the same period. Another group of animals remained untreated throughout gestation. Necropsies were performed on rabbits found dead and on those killed on gestation day 30. Body weight, food and water consumption, and clinical signs were monitored during the experiment. Major organs were weighed when the dams were necropsied on gestation day 30, and litter and fetal data were collected. Abortion and maternal deaths occurred in drug-treated groups. Body weight gains and food and water consumption were adversely affected by treatment particularly at the 250 and 12.5 micrograms/kg dose levels. Wastage (postimplantation loss) was significantly increased among treated groups (all dose levels), while other litter and fetal parameters were unaffected. ONO-802 was not teratogenic at maternal and embryotoxic dose levels.

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Effects of Prostaglandin F2 on Pseudopregnancy and Pregnancy in Mice

Cited by 29 publications

References 13 publications

Effect of Indomethacin, an Inhibitor of Prostaglandin Biosynthesis on the Length of Pseudopregnancy in Rats and Hamsters

Effect of Indomethacin, an Inhibitor of Prostaglandin Biosynthesis on the Length of Pseudopregnancy in Rats and Hamsters

Potential Value of Plants As Sources of New Antifertility Agents I *

Teratology study with the synthetic prostaglandin ONO‐802 given intravaginally to rabbits

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