Effect of Indomethacin, an Inhibitor of Prostaglandin Biosynthesis on the Length of Pseudopregnancy in Rats and Hamsters

Lau, I.F.; Saksena, S.K.; Chang, M. C.

doi:10.1530/acta.0.0780343

Cited by 29 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with previous reports [7,8], systemic administration of DEX or IND prolonged luteal activity in the present study. According to Espey et al [10], systemic injection of IND (0.1 mg/ immature rat ) decreased ovarian PGE and PGF contents to less than 10% in 5 h. While it is described that a single dose of IND can reduce PG levels in the entire body for at least 24 h [21], this drug disappears rapidly from circulation with a plasma half-life of about 6 h [22,23].…”

Section: Discussionsupporting

confidence: 94%

Effects of Intra-ovarian Bursal Injection of Eicosanoid Synthesis Inhibitors on Luteal Function in Immature Pseudopregnant Rats

Kurusu

Hirano

Kawagishi

et al. 1995

Journal of Reproduction and Development

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 94%

Effects of Intra-ovarian Bursal Injection of Eicosanoid Synthesis Inhibitors on Luteal Function in Immature Pseudopregnant Rats

Kurusu

Hirano

Kawagishi

et al. 1995

Journal of Reproduction and Development

View full text Add to dashboard Cite

“…PGF 2a is known to induce luteolytic effects in rodents and ewes (1 -3). For example, indomethacin prolongs the corpus luteal life span in rats (18) and FP receptor-deficient mice cannot deliver pups (4). There are some reports and reviews demonstrating the involvement of apoptosis in the process of PGF 2a -induced luteolysis.…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin F2α-Induced Functional Regression of the Corpus Luteum and Apoptosis in Rodents

et al. 2003

View full text Add to dashboard Cite

Abstract. We investigated the relationship between prostaglandin (PG) F 2a -induced functional luteal regression and apoptosis in the rodent ovary. Administration of PGF 2a significantly decreased the serum levels of progesterone within 12 h after treatment in pseudopregnant mice. Apparent signals were detected in luteal tissues at 24 to 72 h by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick endo labeling (TUNEL) assay. PGF 2a significantly increased the levels of the cleavage nuclear poly (ADP-ribose) polymerase fragment and transforming growth factor-b (TGF-b) mRNA within 48 h. PGF 2a (10 m M) decreased progesterone secretion 6 to 72 h after its addition in luteinized ovarian cells, whereas C2-ceramide (25 m M) decreased progesterone levels by 44% 72 h after its addition. DNA fragmentation was not observed in the cultured cells treated with PGF 2a for 24 h, although cells incubated with C2-ceramide showed fragmentation. Treatment with PGF 2a for 1 h caused a distinct decrease in luteinizing hormone (LH)-induced cyclic AMP production. Thus, the inhibitory effect of PGF 2a on progesterone secretion may be caused by both the blockage of the functional LH receptor and the activation of apoptotic signaling.

show abstract

“…Since the rate of indomethacin released from the Silastic wafers (40 pg/~2 5 mg ovary per day) is more than a hundred times higher than the lethal dose by the subcutaneous route (Lau, Saksena & Chang, 1975;Sato, Taya, Jyujo & Igarachi, 1974) and because at the end of the 7 days of treatment more than half of No. of corpora lutea on days: 15 91 + 10 6-9 + 0-7 5-9 + 0-7 8-2+1-0 6-5 + 0-6 5-9 + 0-6 22 7-7 + 0-5 7-2 + 0-6 6-9 + 0-7 7-2 + 0-3 5-6 + 0-5 6-4+1-8…”

Section: Discussionmentioning

confidence: 99%

Indomethacin treatment prevents prolactin-induced luteolysis in the rat

Sánchez-Criado¹,

Ochiai²,

Rothchild³

1987

Journal of Endocrinology

View full text Add to dashboard Cite

Adult female rats were hypophysectomized and their pituitary glands autotransplanted beneath the left kidney capsule on day 2 (day 1 was the day of ovulation). In such rats the pituitary secretes prolactin fairly constantly and the corpora lutea secrete progesterone for several months. To induce the luteolytic effect of prolactin the rats were first injected s.c. with 2-bromo-alpha-ergocryptine (CB-154) on cycle days 12, 13 and 14 (i.e. 10, 11 and 12 days after operation) to depress prolactin secretion, and then with CB-154 vehicle (70% ethanol) daily until cycle day 21, to allow prolactin secretion to resume. One ovary was removed from each rat on day 15 and the remaining one on day 22. The mean (+/- S.E.M.) weight of the corpora lutea on day 15 was 1.46 +/- 0.06 mg and 0.98 +/- 0.07 mg on day 22 (n = 17). In contrast, rats in which the CB-154 treatment was maintained to day 21 had corpora lutea which weighed 1.31 +/- 0.09 on day 15 and 1.47 +/- 0.08 mg on day 22 (n = 15). To investigate whether indomethacin, a prostaglandin synthesis inhibitor, affected the luteolytic action of prolactin, the experiment was repeated, but on day 15 (after the removal of one ovary) the groups in which CB-154 treatment was stopped, as well as the group in which CB-154 treatment was maintained, were each divided into two groups. In one, indomethacin-containing silicone elastomer wafers and, in the other, blank silicone elastomer wafers, were placed within the bursa of the remaining ovary.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Effect of Indomethacin, an Inhibitor of Prostaglandin Biosynthesis on the Length of Pseudopregnancy in Rats and Hamsters

Abstract: Pseudopregnancy (PSP) in rats was significantly lengthened after subcutaneous administration of 0.2\p=n-\1.0 mg indomethacin/day, starting on day 5 of PSP. Injections of 1 mg indomethacin on days 5 and 6 or days 7 and 8, as well as a single injection of 2 mg indomethacin on day 6,

Cited by 29 publications

References 10 publications

Effects of Intra-ovarian Bursal Injection of Eicosanoid Synthesis Inhibitors on Luteal Function in Immature Pseudopregnant Rats

Effects of Intra-ovarian Bursal Injection of Eicosanoid Synthesis Inhibitors on Luteal Function in Immature Pseudopregnant Rats

Prostaglandin F2α-Induced Functional Regression of the Corpus Luteum and Apoptosis in Rodents

Indomethacin treatment prevents prolactin-induced luteolysis in the rat

Contact Info

Product

Resources

About