Effects of prostaglandin E2 (PGE2) and histamine on renal fluid dynamics

Sinclair, R J; Rd, Bell; Keyl, M. J.

doi:10.1152/ajplegacy.1974.227.5.1062

Cited by 13 publications

(5 citation statements)

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“…Interestingly, the H 4 receptor antagonist JNJ‐39758979 prevented megalin loss in a model of experimental diabetic nephropathy (Pini, Grange et al, 2018). The dysregulation of the reabsortive process at the different levels of the nephron may account for the excretion of electrolytes, particularly sodium, an excretion induced by histamine via H 1 receptors (Banks et al, 1978; Gerber & Nies, 1983; Ichikawa & Brenner, 1979; Laight et al, 1995; R. J. Sinclair, Bell, & Keyl, 1974). Furthermore, a potential role for H 4 receptors should be considered, even if it has yet to be investigated.…”

Section: The Role Of Histamine In the Kidneysmentioning

confidence: 99%

Histamine in the kidneys: what is its role in renal pathophysiology?

Grange

Gurrieri

Verta

et al. 2019

British J Pharmacology

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Starting with a role for histamine role in renal haemodynamics, evidence has accumulated, over time, suggesting a wider range of actions on renal function and this has renewed interest in the pathophysiological role of histamine in the kidney. Here we provide an up-to-date review of this topic. As the kidney expresses enzymes that synthesize and metabolise histamine, along with its receptors, all the components for histaminergic transmission are present in this tissue. The distribution of histamine receptors matches a wide range of effects. We address the questions of the redundancy of H 1 and H 2 receptors in renal haemodynamics, the complementary role of H 1 and H 4 receptors in renal filtration and reabsorption, and the dichotomy between local and neuronal H 1 and H 3 receptors. Experimental models of renal disease raise the possibility of new therapeutic approaches based on histamine. The effects of histamine on renal function are not yet fully understood and their elucidation is still ongoing. LINKED ARTICLES: This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit

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Section: The Role Of Histamine In the Kidneysmentioning

confidence: 99%

Histamine in the kidneys: what is its role in renal pathophysiology?

Grange

Gurrieri

Verta

et al. 2019

British J Pharmacology

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“…In the kidney of diabetic rats, histamine was increased compared with controls [2]. Basically, histamine has been reported to regulate the renal microcirculation, to increase salt and water excretion [3][4][5], decrease the ultrafiltration coefficient by reducing the total filtration surface area [4], and increase renin release [6].…”

Section: Introductionmentioning

confidence: 99%

H3 receptor renal expression in normal and diabetic rats

et al. 2015

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“…Actually, the first evidence for a possible role of histamine in diabetic nephropathy was provided in the 1960s when, concurrent with an increased tissue HDC activity, an increased level of this amine was observed in the kidney of diabetic animals [12,13]. In particular, histamine has already been demonstrated to increase salt and water excretion [14][15][16] and renin release [17], and to decrease the ultrafiltration coefficient [18]. These effects were classically attributed to the well-known vasoactive properties of the amine.…”

Section: Introductionmentioning

confidence: 99%

Histamine H 4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice

Pini

Grange

Veglia

et al. 2018

Pharmacological Research

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Due to the incidence of diabetes and the related morbidity of diabetic nephropathy, identification of new therapeutic strategies represents a priority. In the last few decades new and growing evidence on the possible role of histamine in diabetes has been provided. In particular, the histamine receptor HR is emerging as a new promising pharmacological target for diabetic nephropathy. The aim of this study was to evaluate the efficacy of selective HR antagonism by JNJ39758979 on the prevention of diabetic nephropathy progression in a murine model of diabetes induced by streptozotocin injection. JNJ39758979 (25, 50, 100 mg/kg/day p.o.) was administered for 15 weeks starting from the onset of diabetes. Functional parameters were monitored throughout the experimental period. JNJ39758979 did not significantly affect glycaemic status or body weight. The urine analysis indicated a dose-dependent inhibitory effect of JNJ39758979 on Albumin-Creatinine-Ratio, the Creatinine Clearance, the 24 h urine volume, and pH urine acidification (P < 0.05). The beneficial effects of JNJ39758979 on renal function paralleled comparable effects on renal morphological integrity. These effects were sustained by a significant immune infiltration and fibrosis reduction. Notably, megalin and sodium-hydrogen-exchanger 3 expression levels were preserved. Our data suggest that the HR participates in diabetic nephropathy progression through both a direct effect on tubular reabsorption and an indirect action on renal tissue architecture via inflammatory cell recruitment. Therefore, HR antagonism emerges as a possible new multi-mechanism therapeutic approach to counteract development of diabetic nephropathy development.

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Effects of prostaglandin E2 (PGE2) and histamine on renal fluid dynamics

Cited by 13 publications

References 0 publications

Histamine in the kidneys: what is its role in renal pathophysiology?

Histamine in the kidneys: what is its role in renal pathophysiology?

H3 receptor renal expression in normal and diabetic rats

Histamine H 4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice

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