Effects of prostaglandin E2 and DL204 IT, an inhibitor of prostaglandin degradation, on ovulation and ovum transport in the hamster

Lerner, Leonard J.; Oldani, Claudia; Vitale, A

doi:10.1016/0090-6980(78)90136-3

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…This is in agreement with the results obtained by others [15,23] suggesting that prostaglandins do not play a significant role in the control of oviductal transport in the hamster. The leukotriene synthesis inhibitor NDGA significantly delayed the transport of embryos to the uterus; the effect was limited to pregnant animals, since oocyte transport in cycling animals was not affected.…”

Section: Discussionsupporting

confidence: 93%

Possible Role of Platelet-Activating Factor in Embryonic Signaling during Oviductal Transport in the Hamster1

Velásquez

Aguilera

Croxatto³

1995

Biology of Reproduction

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Hamster embryos enter the uterus in pregnant females nearly one day earlier than unfertilized eggs in cycling females. The hypothesis that a substance derived from eicosanoids is released by the embryos, but not by oocytes, to hasten their transport to the uterus was tested by examining the effects of indomethacin, nordihydroguaiaretic acid (NDGA), platelet-activating factor (PAF), and PAF antagonists on egg transport in the hamster. Administration of indomethacin had no effect on embryo transport, whereas administration of NDGA delayed the transport of eggs to the uterus in pregnant but not in cycling hamsters. The PAF antagonists TCV-309 and BN-52021 delayed significantly the transport of eggs to the uterus in pregnant animals, but not in cycling animals; i.e., they retarded the passage of embryos but not of oocytes to the uterus. Administration of PAF to cycling hamsters hastened the oviductal transport of ova. These data suggest that, in the hamster, the earlier passage of embryos to the uterus as compared to oocytes is mediated by PAF. Thrombocytopenia was detected in early-pregnant hamsters, and PAF-like activity was detected in spent media of two-cell through morula stage hamster embryos. These results suggest that preimplantation hamster embryos produce PAF-like activity that mediates embryonic signaling to the oviduct as well as pregnancy-associated thrombocytopenia.

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Section: Discussionsupporting

confidence: 93%

Possible Role of Platelet-Activating Factor in Embryonic Signaling during Oviductal Transport in the Hamster1

Velásquez

Aguilera

Croxatto³

1995

Biology of Reproduction

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Drugs that block smooth muscle contraction inhibit in vivo ovulation in hamsters

Martin

Talbot

1981

J. Exp. Zool.

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We have demonstrated previously that smooth muscle cells (SMC) in the base of hamster follicles contract minutes before ovulation. The contraction of these cells correlates well in time with the development of a constriction in the base of the follicle. The purpose of this study was to determine whether contraction of SMC (1) produces this constriction and (2) is necessary for ovulation. We treated preovulatory hamster ovaries with six classes of drugs (lanthanides, calcium antagonists, local anesthetics, prostaglandins, cAMP modulators, and cytochalasin B) known to inhibit SMC contraction in other tissues. Drugs were injected into the experimental bursal cavity of a hamster 3 hours before ovulation; the contralateral ovary received no treatment and served as a control. Three hours after ovulation, the number of ruptured follicles on experimental and control ovaries were compared by light and electron microscopy. All the smooth muscle (SM) inhibitors, except those that affect cAMP levels and cytochalasin B, prevented (1) contraction of follicular SM, (2) constriction of the base of the follicle, and (3) ovulation. These results support the idea that contraction of follicular SMC constricts the follicle and is required for ovulation. The results further show that follicular SMC are activated by an influx of extracellular calcium and that prostaglandin F2 alpha may be involved in promoting this contraction.

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A review — Role of eicosanoids in vertebrate ovulation

1993

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Effects of prostaglandin E2 and DL204 IT, an inhibitor of prostaglandin degradation, on ovulation and ovum transport in the hamster

Cited by 8 publications

References 21 publications

Possible Role of Platelet-Activating Factor in Embryonic Signaling during Oviductal Transport in the Hamster1

Possible Role of Platelet-Activating Factor in Embryonic Signaling during Oviductal Transport in the Hamster1

Drugs that block smooth muscle contraction inhibit in vivo ovulation in hamsters

A review — Role of eicosanoids in vertebrate ovulation

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