“…The actual degree of variation of IPSP parameters with propofol concentration observed physiologically is highly dependent on the brain region studied, the neurotransmittor receptors considered, and the experimental preparation, whether it be cell cultures or isolated cells (Krasowski et al, 1998;Bai et al, 1999Bai et al, , 2001Siegwart et al, 2002;Dong & Xu, 2002;Feng & 470 Macdonald, 2004;Drexler et al, 2009;Yue et al, 2011;Wakita et al, 2013), or tissue slices (Collins, 1988;Bieda & MacIver, 2004;Wang et al, 2004;Ying & Goldstein, 2005;Wang, 2009). In tissue slices, measurements focus more directly on PSP-level parameters and appear to indicate a greater sensitivity to propofol of the IPSP rate constant than for IPSP amplitude, however, there are still observed variations in both parameters depending on the preparation (Collins, 1988;Bieda & MacIver, 2004;Wang et al, 2004;Ying & Goldstein, 2005;Wang, 2009).…”