Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats

Zhu, Jun; Chang, Chen; Wu, Jinfeng; He, Ming; Li, Shuang; Fang, Yuanyuan; Yan, Zhenlin; Xu, Haibo; Sadigh-Eteghad, Saeed; Manyande, Anne; Zheng, Feng; Chen, Ting; Xu, Fuqiang; Ma, Ding; Wang, Jie; Zhang, Zongze

doi:10.1016/j.bja.2023.05.025

Cited by 6 publications

(7 citation statements)

References 35 publications

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“…The prefrontal cortex and the hippocampus share some similarities. For instance, both are vital neural structures in the brain and are crucial for normal emotion, social interaction, perception, and attention (Zhu et al, 2023). However, the prefrontal cortex and the hippocampus also exhibit certain distinctions.…”

Section: Discussionmentioning

confidence: 99%

“…However, the prefrontal cortex and the hippocampus also exhibit certain distinctions. The medial prefrontal cortex subregions have long been thought to play a critical role in emotional and social processing, whereas the hippocampus is primarily involved in the formation of short-term and long-term memories (Zhu et al, 2023). In future studies, we intend to further investigate the specific roles and interactions of the prefrontal cortex and the hippocampus in neurodevelopmental toxicity induced by general anesthetics.…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory neuron map of sevoflurane induced neurotoxicity model in young primates

Niu,

Cheng,

Miao

et al. 2023

Front. Cell. Neurosci.

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IntroductionSevoflurane, one of the most commonly used anesthetic agents in children, may induce neuronal dysfunction and cognitive impairment. Exposure to sevoflurane might induce an imbalance between neural excitation and inhibition which could be a mechanism behind anesthesia-induced cognitive and affective dysfunctions. However, the underlying mechanisms remain unclear.MethodsIn this study, we used two rhesus macaques in the control group, and one rhesus macaques in the anesthesia group. We employed single-nucleus RNA sequencing (snRNA-seq) technology to explore alterations in distinct types of inhibitory neurons involved in the long-term cognitive impairment caused by sevoflurane in young macaques.ResultsFollowing sevoflurane treatment, an upregulation was observed in the SST+ inhibitory neuron in the LHX6+ neighborhood in the hippocampus of rhesus macaques. This alteration might impact brain development by influencing interneuron migration and maturation. Additionally, we proposed a novel classification of inhibitory neurons, defined by CNR1 and LHX6 applicable to both humans and macaques.DiscussionOur study proposed a novel classification of inhibitory neurons defined by LHX6 and CNR1, relevant in macaques and humans. We also provide evidence that sevoflurane upregulated the SST+ inhibitory neuron in the LHX6+ neighborhood in the hippocampus of rhesus macaques, which may underlie the potential neurotoxic effects induced by general anesthetics. Our results also offer a more reliable approach for studying the structure and function of the human brain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhibitory neuron map of sevoflurane induced neurotoxicity model in young primates

Niu,

Cheng,

Miao

et al. 2023

Front. Cell. Neurosci.

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“…The sleep stages in the recordings were scored by AI-driven software, Lunion Stage, developed by LunionData 62 ( https://www.luniondata.com/en/lunion_stage ). The AI engine of Lunion Stage employs a convolutional neural network, which is a type of deep learning model.…”

Section: Methodsmentioning

confidence: 99%

40 Hz light flickering promotes sleep through cortical adenosine signaling

Zhou,

He,

et al. 2024

Cell Res

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Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical underpinning has hampered its therapeutic development. Here, we demonstrate that light flickering triggered an immediate and sustained increase (up to 3 h after flickering) in extracellular adenosine levels in the primary visual cortex (V1) and other brain regions, as a function of light frequency and intensity, with maximal effects observed at 40 Hz frequency and 4000 lux. We uncovered cortical (glutamatergic and GABAergic) neurons, rather than astrocytes, as the cellular source, the intracellular adenosine generation from AMPK-associated energy metabolism pathways (but not SAM-transmethylation or salvage purine pathways), and adenosine efflux mediated by equilibrative nucleoside transporter-2 (ENT2) as the molecular pathway responsible for extracellular adenosine generation. Importantly, 40 Hz (but not 20 and 80 Hz) light flickering for 30 min enhanced non-rapid eye movement (non-REM) and REM sleep for 2–3 h in mice. This somnogenic effect was abolished by ablation of V1 (but not superior colliculus) neurons and by genetic deletion of the gene encoding ENT2 (but not ENT1), but recaptured by chemogenetic inhibition of V1 neurons and by focal infusion of adenosine into V1 in a dose-dependent manner. Lastly, 40 Hz light flickering for 30 min also promoted sleep in children with insomnia by decreasing sleep onset latency, increasing total sleep time, and reducing waking after sleep onset. Collectively, our findings establish the ENT2-mediated adenosine signaling in V1 as the neurochemical basis for 40 Hz flickering-induced sleep and unravel a novel and non-invasive treatment for insomnia, a condition that affects 20% of the world population.

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Section: Does Sleep Promotion Induce Fast Surgical Recovery?mentioning

confidence: 99%

“…In animals, it has been showed that propofol protected against anxiety behaviors induced by sleep deprivation, reducing symptoms. 14 Propofol might be superior to sevoflurane for patients with sleep disorders who receive anesthesia, which should be tested in clinical studies. 5 The role of the hospital's environment and early postoperative discomforts is well established, as well as the influence of frequent patient care activities and noise during sleep-time in patients who had undergone surgery.…”

Section: Does Sleep Promotion Induce Fast Surgical Recovery?mentioning

confidence: 99%

Can Improving Postoperative Sleep Speed Up Surgical Recovery?

da Silva,

Guerreiro,

Barreto

et al. 2024

Sleep Sci

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Sleep disturbance is common during recovery after surgical procedures and may have an important effect on mortality, and quality of life. Sleep restriction/deprivation, including decreased quantity and continuity, is common in patients who are patients and persons with acute and chronic illnesses. Age, gender, illness, primary sleep disorders, environment, and medical treatment factors are thought to influence sleep throughout the preoperative period, hospitalization, and recovery. Resulting sleep pattern disturbances include decreases in circadian patterning, continuity, duration, and perceived (subjective) sleep quality. This article synthesizes sleep disturbance in patients who have undergone surgery and highlights sleep strategies to improve faster surgical recovery.

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Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats

Cited by 6 publications

References 35 publications

Inhibitory neuron map of sevoflurane induced neurotoxicity model in young primates

Inhibitory neuron map of sevoflurane induced neurotoxicity model in young primates

40 Hz light flickering promotes sleep through cortical adenosine signaling

Can Improving Postoperative Sleep Speed Up Surgical Recovery?

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