Effects of Propionate on Lipid Biosynthesis in Isolated Rat Hepatocytes

Nishina, Patsy M.; Freedland, R. A.

doi:10.1093/jn/120.7.668

Cited by 209 publications

(109 citation statements)

References 24 publications

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“…Another recent study suggested a role for differences in intestinal methane production in altered glycemic control in diabetic subjects [34], further supporting our finding of altered glucose levels in methane-producing individuals, and methane producers have also been shown to have higher fasting serum cholesterol concentrations when compared to age-, sex-, and BMI-matched non-methane producers. The alteration between systemic availability of acetate and propionate produced during carbohydrate fermentation by methanogenic archaea has been suggested to influence doi: 10.7243/2053-3640-2-2 the blood lipid levels [35][36][37]. Using an animal model and ex vivo studies, our group has also shown that methane may also directly affect intestinal transit and gut neuromuscular function [38], findings which have since been confirmed by an independent group [39].…”

Section: Discussionmentioning

confidence: 60%

Methane-producing human subjects have higher serum glucose levels during oral glucose challenge than non-methane producers: a pilot study of the effects of enteric methanogens on glycemic regulation

Mathur¹,

Goyal²,

Kim³

et al. 2014

Res J Endocrinol Metab

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Background: Recent studies support that intestinal microbes contribute to human disease, and enteric methanogens have been specifically linked to altered gut metabolism and weight gain. In this study, we tested whether methane on breath test (as a surrogate for colonization with the predominant methanogen Methanobrevibacter smithii) is associated with altered glucose tolerance in humans. Methods: Consecutive methane producing (methane ≥3ppm, N=5) and non-methane producing (methane <3ppm, N=15) subjects undergoing lactulose breath test at our center were recruited and subjected to a 75 g oral glucose tolerance test (OGTT). Results: The average age of methane-producing subjects was 48.8±10.0 vs. 37.7±12.1 for non-methane subjects (P=0.17). Methane and non-methane subjects also had comparable mean body mass index (BMI) (23.9±0.2 vs. 25.0±8.0 kg/m2; P=0.53) and baseline insulin resistance (HOMA-IR) (1.32±0.72 vs. 2.21±1.52; P=0.23). During 180 minutes post-glucose load, methane producers had greater serum glucose area-under-the-curve (AUC) (774.2±140.3 mg/dL) than non-methane subjects (585.5±128.3 mg/dL) (P=0.03), but similar insulin AUC (217.76±122.08 μU/mL vs. 215.37±75.02 μU/mL, respectively). Conclusions: Individuals with methane on breath test (reflecting higher colonization with enteric methanogens, predominantly M. smithii) may have impaired glucose tolerance when challenged with a high carbohydrate load, and may also have a higher susceptibility to hyperglycemia which appears to be independent of basal insulin resistance and BMI.

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Section: Discussionmentioning

confidence: 60%

Methane-producing human subjects have higher serum glucose levels during oral glucose challenge than non-methane producers: a pilot study of the effects of enteric methanogens on glycemic regulation

Mathur¹,

Goyal²,

Kim³

et al. 2014

Res J Endocrinol Metab

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“…It has also been suggested that hypocholesterolemic effect of dietary fi bres might also be mediated by the short chain fatty acids from fi bre fermentation. Propionate is reported to inhibit fatty acid metabolism, which plays a key role in the synthesis of cholesterol (Nishina and Freeland 1990, Wright et al 1990, Demignè et al 1995.…”

Section: Dietary Fi Bre and Health Benefi Tsmentioning

confidence: 99%

Dietary fibre as functional ingredient in meat products: a novel approach for healthy living — a review

2010

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There is a rapid change in our overall lifestyle due to impact of globalization. Every day hasty life has forced consumers to be dependent upon fast foods, which contain meagre amount of dietary fi bre. Non-starch polysaccharides and resistant oligosaccharides, lignin, substances associated with NSP and lignin complex in plants, other analogous carbohydrates, such as resistant starch and dextrins, and synthesized carbohydrate compounds, like polydextrose are categorized as dietary fi bre. They are mostly concentrated in cereals, pulses, fruits and vegetables. It has been proclaimed that daily dietary fi bre intake helps in prevention of many nutritional disorders like gut related problems, cardiovascular diseases, type 2 diabetes, certain types of cancer and obesity. Meat is generally lacking this potential ingredient, which could be incorporated while products processing to make them more healthful. Various fi bre rich sources have been attempted in different products attributed to their technological and health benefi ts and many are in the queue to be used in a variety of meat products. Selection of appropriate fi bre rich ingredients and their proper incorporation can improve health image of meat products.

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“…Our results showed that propionate prevented cellular TG accumulation in YAMC cells through the induction of PPARa expression. Evidence has been accumulating that propionate has fatty acid-lowering effects through the inhibition of fatty acid production in the liver (24). Additionally, the decreases in fatty acid levels by propionate probably derive from the inhibition of lipolysis and the induction of adipogenesis in adipose tissue (25).…”

Section: Discussionmentioning

confidence: 99%

Propionate Promotes Fatty Acid Oxidation through the Up-Regulation of Peroxisome Proliferator-Activated Receptor α in Intestinal Epithelial Cells

Higashimura

Naito

Takagi

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Short chain fatty acids (SCFAs) are produced in the colonic lumen mainly by bacterial fermentation of dietary fiber. Emerging evidence shows that SCFA has important physiological and pathophysiological effects on colonic and systemic events. Recently, propionate, known as a kind of SCFA, has been shown to lower fatty acid contents in plasma and reduce food intake. However, the detailed mechanism underlying the propionate-mediated lipid metabolism action remains poorly understood. The intestinal lipid metabolism process is critical for systemic energy homeostasis. Therefore, we investigate here the effects of propionate on intestinal lipid metabolism. Results show that propionate induced peroxisome proliferator-activated receptor a (PPARa) expression time-dependently and concentrationdependently in YAMC (a mouse intestinal epithelial cell line) cells. The expression levels of PPARa-responsive genes such as carnitine palmitoyl transferase II (CPTII) and trifunctional protein a (TFPa) were up-regulated in the presence of propionate, thereby suppressing triglyceride (TG) accumulation. Furthermore, propionate-mediated PPARa induction required phosphorylation of extracellular signal-regulated kinase. Collectively, these data indicate that propionate regulates intestinal lipid metabolism through the induction of PPARa expression. Results suggest that the inhibitory effect of propionate on TG accumulation partly contributes to the propionate-mediated fatty acid-lowering effect.

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Effects of Propionate on Lipid Biosynthesis in Isolated Rat Hepatocytes

Cited by 209 publications

References 24 publications

Methane-producing human subjects have higher serum glucose levels during oral glucose challenge than non-methane producers: a pilot study of the effects of enteric methanogens on glycemic regulation

Methane-producing human subjects have higher serum glucose levels during oral glucose challenge than non-methane producers: a pilot study of the effects of enteric methanogens on glycemic regulation

Dietary fibre as functional ingredient in meat products: a novel approach for healthy living — a review

Propionate Promotes Fatty Acid Oxidation through the Up-Regulation of Peroxisome Proliferator-Activated Receptor α in Intestinal Epithelial Cells

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Effects of Propionate on Lipid Biosynthesis in Isolated Rat Hepatocytes

Cited by 209 publications

References 24 publications

Methane-producing human subjects have higher serum glucose levels during oral glucose challenge than non-methane producers: a pilot study of the effects of enteric methanogens on glycemic regulation

Methane-producing human subjects have higher serum glucose levels during oral glucose challenge than non-methane producers: a pilot study of the effects of enteric methanogens on glycemic regulation

Dietary fibre as functional ingredient in meat products: a novel approach for healthy living — a review

Propionate Promotes Fatty Acid Oxidation through the Up-Regulation of Peroxisome Proliferator-Activated Receptor &alpha; in Intestinal Epithelial Cells

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Propionate Promotes Fatty Acid Oxidation through the Up-Regulation of Peroxisome Proliferator-Activated Receptor α in Intestinal Epithelial Cells