2014
DOI: 10.7243/2053-3640-2-2
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Methane-producing human subjects have higher serum glucose levels during oral glucose challenge than non-methane producers: a pilot study of the effects of enteric methanogens on glycemic regulation

Abstract: Background: Recent studies support that intestinal microbes contribute to human disease, and enteric methanogens have been specifically linked to altered gut metabolism and weight gain. In this study, we tested whether methane on breath test (as a surrogate for colonization with the predominant methanogen Methanobrevibacter smithii) is associated with altered glucose tolerance in humans. Methods: Consecutive methane producing (methane ≥3ppm, N=5) and non-methane producing (methane <3ppm, N=15) subjects undergo… Show more

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Cited by 16 publications
(30 citation statements)
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References 37 publications
(53 reference statements)
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“…In human studies, we showed that methane‐producing individuals with obesity had a 6.8 kg/m 2 greater BMI than nonmethane producing controls with obesity and subsequently demonstrated that methane and hydrogen on breath test was associated with both greater BMI and higher percent body fat in a general population cohort ( N = 792 subjects) . We have also shown that methane‐producing individuals may have impaired glucose tolerance when challenged with a high carbohydrate load, as well as a higher susceptibility to hyperglycemia . These data support our current findings that eradication of methanogens results in improved glucose and insulin levels, which are also supported by a recent independent study suggesting a role for intestinal methane production differences in altered glycemic control in diabetic subjects .…”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…In human studies, we showed that methane‐producing individuals with obesity had a 6.8 kg/m 2 greater BMI than nonmethane producing controls with obesity and subsequently demonstrated that methane and hydrogen on breath test was associated with both greater BMI and higher percent body fat in a general population cohort ( N = 792 subjects) . We have also shown that methane‐producing individuals may have impaired glucose tolerance when challenged with a high carbohydrate load, as well as a higher susceptibility to hyperglycemia . These data support our current findings that eradication of methanogens results in improved glucose and insulin levels, which are also supported by a recent independent study suggesting a role for intestinal methane production differences in altered glycemic control in diabetic subjects .…”
Section: Discussionsupporting
confidence: 85%
“…Effects of Antibiotic Reduction of Breath Methane Mathur et al cohort (N 5 792 subjects) (15). We have also shown that methaneproducing individuals may have impaired glucose tolerance when challenged with a high carbohydrate load, as well as a higher susceptibility to hyperglycemia (16). These data support our current findings that eradication of methanogens results in improved glucose and insulin levels, which are also supported by a recent independent study suggesting a role for intestinal methane production differences in altered glycemic control in diabetic subjects (17).…”
Section: Obesitymentioning
confidence: 64%
“…These studies, which are independent of the potential issues surrounding techniques for the amplification of methanogens as well as fecal vs small intestinal sampling, support a role for methanogens in host weight gain. We have shown (1) that intestinal methane production is associated with impaired glucose tolerance, 110 which is consistent with independent data demonstrating that methane‐producing subjects with type 1 DM exhibited poorer glycemic control than that of non–methane producers, and (2) that reductions in CH 4 production after metronidazole therapy resulted in significant improvements in HbA1c 111 . Taken together, these data suggest that GI colonization with methanogens may contribute to altered glucose metabolism and the development of obesity.…”
Section: The Role Of Methanogenic Archaea In Host Metabolism and The supporting
confidence: 90%
“…Similarly, methane is one of the least explored fermentation by-products of gut Archea. A recent study from Mathur et al (2014) showed that individuals with higher numbers of enteric methanogens (methane-producing Archea) may have impaired glucose tolerance when challenged with a diet rich in carbohydrates and may also have a higher susceptibility to hyperglycemia, independent of basal insulin resistance and BMI. Thus, different microbiota-derived gaseous modulators may have a significant impact on host metabolism that still needs to be explored.…”
Section: Microbial Metabolites Following Interactions With the Dietmentioning
confidence: 99%