Effects of probiotics in periodontal diseases: a systematic review

Yanine, Nicolás; Araya, Ignacio; Brignardello‐Petersen, Romina; Carrasco-Labra, Alonso; González, Almudena Cabezas; Preciado, Arelis; Villanueva, Julio; Sanz, Mariano; Martín, Conchita

doi:10.1007/s00784-013-0990-7

Cited by 52 publications

(35 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several in vitro studies (Teughels et al, 2007; van Essche et al, 2012) and recent clinical studies (Iniesta et al, 2012; Teughels et al, 2013; Yanine et al, 2013) have suggested that these allegedly beneficial bacteria can cause antagonism toward Gram-negative bacteria.…”

Section: Discussionmentioning

confidence: 99%

Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults

Mostajo

Reijden

Buijs

et al. 2014

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Oral bacteria live in symbiosis with the host. Therefore, when mouthwashes are indicated, selective inhibition of taxa contributing to disease is preferred instead of broad-spectrum antimicrobials. The potential selectivity of an oxygenating mouthwash, Ardox-X® (AX), has not been assessed. The aim of this study was to determine the antimicrobial potential of AX and the effects of a twice-daily oral rinse on dental plaque composition.Material and methods: In vitro, 16 oral bacterial strains were tested using agar diffusion susceptibility, minimum inhibitory and minimum bactericidal concentration tests. A pilot clinical study was performed with 25 healthy volunteers. Clinical assessments and microbiological sampling of supragingival plaque were performed at 1 month before the experiment (Pre-exp), at the start of the experiment (Baseline) and after the one-week experimental period (Post-exp). During the experiment individuals used AX mouthwash twice daily in absence of other oral hygiene measures. The microbiological composition of plaque was assessed by 16S rRNA gene amplicon sequencing.Results: AX showed high inter-species variation in microbial growth inhibition. The tested Prevotella strains and Fusobacterium nucleatum showed the highest sensitivity, while streptococci and Lactobacillus acidophilus were most resistant to AX. Plaque scores at Pre-exp and Baseline visits did not differ significantly (p = 0.193), nor did the microbial composition of plaque. During a period of 7-days non-brushing but twice daily rinsing plaque scores increased from 2.21 (0.31) at Baseline to 2.43 (0.39) Post-exp. A significant microbial shift in composition was observed: genus Streptococcus and Veillonella increased while Corynebacterium, Haemophilus, Leptotrichia, Cardiobacterium and Capnocytophaga decreased (p ≤ 0.001).Conclusion: AX has the potential for selective inhibition of oral bacteria. The shift in oral microbiome after 1 week of rinsing deserves further research.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults

Mostajo

Reijden

Buijs

et al. 2014

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Evidence suggests that probiotics could be beneficial during periodontal therapy because they may aid in the reduction of pathogenic bacteria 14 and/or serve as anti‐inflammatory adjuncts 15 , 26 . However, a recent review concludes that more studies are necessary to evaluate the efficacy of probiotics in oral health maintenance 27 and to understand the mechanisms by which ingested bacteria target microbiome functions contributing to the prevention and management of major health concerns 28 . This study proposes that a treatment involving non‐surgical therapy plus intake of a L. rhamnosus SP1‐containing probiotic sachet may result in improved clinical effects compared with conventional mechanical therapy for CP.…”

mentioning

confidence: 99%

Clinical Effects of Lactobacillus rhamnosus in Non‐Surgical Treatment of Chronic Periodontitis: A Randomized Placebo‐Controlled Trial With 1‐Year Follow‐Up

Morales

Carvajal

Silva

et al. 2016

Journal of Periodontology

126

View full text Add to dashboard Cite

show abstract

“…Several clinical trials were conducted in order to study the effect of administration of probiotics in initial treatment of periodontitis [114][115][116][117]. The bacteria most frequently used as probiotic are L. reuteri (DSM 17938 + ATCC PTA 5289) [72,[118][119][120], Lactibacillus salivarius WB21 [121,122], L. reuteri (ATCC 55730 + ATCC PTA 5289) [123], L. reuteri (ATCC PTA 5289) [61], Streptoccus oralis KJ3 + Streptococcus uberis KJ2 + Streptoccus rattus JH145 [124] and L. rhamnosus SP1 [125].…”

Section: Probiotics and Periodontitismentioning

confidence: 99%

Probiotics and Periodontal Diseases

Morales¹,

Bravo²,

Bedoya³

et al. 2017

Insights Into Various Aspects of Oral Health

View full text Add to dashboard Cite

Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Probiotics have been used to directly modify the resident oral microbiome and proposed to modulate immune responses. In dentistry, probiotics have been employed as useful adjuncts for the reduction of caries development, suppressing oral Candida infection and controlling halitosis. Plaque-induced gingivitis is a gingival inflammation caused by the adherent bacterial biofilm around teeth. Gingivitis and periodontitis are considered to be a continuum of the same inflammatory process, although many gingivitis lesions do not progress to periodontitis. Periodontitis is an inflammatory process that affects the attachment structures of teeth. It constitutes a second cause of tooth loss worldwide. Conventional treatment modalities of periodontal disease include non-surgical and/or surgical management, with an emphasis on mechanical debridement. However, mechanical debridement as a sole therapy is not always effective to improve clinical parameters. A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis. Oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease. Probiotics may serve as adjunct or replacement therapy substitute antibiotics in managing human periodontal infections in future.

show abstract

Effects of probiotics in periodontal diseases: a systematic review

Abstract: The use of probiotics are described to prevent or treat periodontal diseases in some clinical trials; therefore, a systematic review of the evidence for the effect of periodontal diseases is needed.

Cited by 52 publications

References 13 publications

Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults

Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults

Clinical Effects of Lactobacillus rhamnosus in Non‐Surgical Treatment of Chronic Periodontitis: A Randomized Placebo‐Controlled Trial With 1‐Year Follow‐Up

Probiotics and Periodontal Diseases

Contact Info

Product

Resources

About