Effects of probiotic supplementation on very low dose AFB1-induced neurotoxicity in adult male rats

Şahin, Gizem Aytekin; Karabulut, Derya; Ünal, Gökhan; Şahin, Habibe

doi:10.1016/j.lfs.2022.120798

Cited by 17 publications

(13 citation statements)

References 57 publications

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“…Furthermore, a recent data by Aytekin et al ( 64 ) reported that AFB1 (25 μg/kg) prolonged immobility time of rats in FST and caused oxidative damage in the brain and triggered inflammatory processes, resulting in anxiety and depression-like behaviors. Oxidative stress plays an essential role in developing behavioral impairment, and depression or anxiety are also related to concomitant oxidative damage and inflammation ( 65 ).…”

Section: Resultsmentioning

confidence: 98%

Effect of aflatoxin B1 exposure on the progression of depressive-like behavior in rats

et al. 2022

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While it is well documented that aflatoxin B1 (AFB1); one of the most toxic food contaminants is linked to the development of depression. However, the mechanism on how it affects the gut and brain health leading to depressive-like behavior remains unclear. This study was conducted to determine the effect of AFB1 on the progression of depressive-like behavior. Thirty-two (n = 32) male Sprague Dawley rats were randomly allocated into four groups: control, low-dose (5 μg AFB1/kg), high-dose (25 μg AFB1/kg) and positive control group; exposed on chronic unpredictable mild stress (CUMS). After 4 weeks of exposure, sucrose preference test (SPT) and force swim test (FST) were used to measure behavioral despair. Fecal samples were selectively cultured to profile the bacteria. Body weight and relative organs weights were compared among groups. AFB1 and CUMS caused reduction in body weight and food intake as well as increased relative weight of adrenal glands, liver, and brain. Rats in AFB1 and CUMS groups had suppressed sucrose preference and prolonged immobility time in FST, wherein this could indicate anhedonia. Besides, fecal count of Lactobacillus spp. was significantly low following AFB1 exposure, with increasing count of Bifidobacterium spp, in comparison to the control. Indeed, further biochemical analysis and metagenomic approach are warranted to explore the underlying mechanisms on the role of gut microbiota dysbiosis and dysregulation of gut-brain axis due to AFB1 neurotoxicity on the progression of depressive-like behavior.

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Section: Resultsmentioning

confidence: 98%

Effect of aflatoxin B1 exposure on the progression of depressive-like behavior in rats

et al. 2022

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“…LAB probiotic (VSL#3 ® ) supplementation in aflatoxin-B1-induced neurotoxicity in adult male rats resulted in decreased oxidative stress and inflammatory markers. The probiotic supplementation is effective at reducing the neurotoxic effects of aflatoxin B1 in rats [ 54 ]. Another LAB probiotic formulation known as ProBiotic-4 significantly improved the memory deficits, cerebral neuronal and synaptic injuries, glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice.…”

Section: Resultsmentioning

confidence: 99%

Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review

et al. 2023

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Background: In recent years, the potential role of probiotics has become prominent in the discoveries of neurotherapy against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties and exert their effects via various mechanisms of actions. This review aimed to evaluate the effects of LAB on neuroprotection reported in the literature. Methods: A database search on Google Scholar, PubMed, and Science Direct revealed a total of 467 references, of which 25 were included in this review based on inclusion criteria which comprises 7 in vitro, 16 in vivo, and 2 clinical studies. Results: From the studies, LAB treatment alone or in probiotics formulations demonstrated significant neuroprotective activities. In animals and humans, LAB probiotics supplementation has improved memory and cognitive performance mainly via antioxidant and anti-inflammatory pathways. Conclusions: Despite promising findings, due to limited studies available in the literature, further studies still need to be explored regarding synergistic effects, efficacy, and optimum dosage of LAB oral bacteriotherapy as treatment or prevention against neurodegenerative diseases.

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“…Moreover, Aytekin Sahin et al. (2022) have shown that the Bifidobacterium strain can ameliorate AFB 1 ‐induced toxicity through its antioxidant and anti‐inflammatory effects. In the case of OTA‐induced damage in rabbits, experimental results have revealed that the administration of Aspergillus awamori significantly improved the condition by regulating oxidative stress and immunity (El‐Deep et al., 2020).…”

Section: Effect Of Probiotics On Exposure To Foodborne Mycotoxinsmentioning

confidence: 99%

Insights into the intestinal toxicity of foodborne mycotoxins through gut microbiota: A comprehensive review

Ruan,

Huang,

Yue

et al. 2023

Comp Rev Food Sci Food Safe

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Mycotoxins, which are fungal metabolites, pose a significant global food safety concern by extensively contaminating food and feed, thereby seriously threatening public health and economic development. Many foodborne mycotoxins exhibit potent intestinal toxicity. However, the mechanisms underlying mycotoxin‐induced intestinal toxicity are diverse and complex, and effective prevention or treatment methods for this condition have not yet been established in clinical and animal husbandry practices. In recent years, there has been increasing attention to the role of gut microbiota in the occurrence and development of intestinal diseases. Hence, this review aims to provide a comprehensive summary of the intestinal toxicity mechanisms of six common foodborne mycotoxins. It also explores novel toxicity mechanisms through the “key gut microbiota–key metabolites–key targets” axis, utilizing multiomics and precision toxicology studies with a specific focus on gut microbiota. Additionally, we examine the potential beneficial effects of probiotic supplementation on mycotoxin‐induced toxicity based on initial gut microbiota‐mediated mycotoxicity. This review offers a systematic description of how mycotoxins impact gut microbiota, metabolites, and genes or proteins, providing valuable insights for subsequent toxicity studies of mycotoxins. Furthermore, it lays a theoretical foundation for preventing and treating intestinal toxicity caused by mycotoxins and advancing food safety practices.

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Effects of probiotic supplementation on very low dose AFB1-induced neurotoxicity in adult male rats

Cited by 17 publications

References 57 publications

Effect of aflatoxin B1 exposure on the progression of depressive-like behavior in rats

Effect of aflatoxin B1 exposure on the progression of depressive-like behavior in rats

Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review

Insights into the intestinal toxicity of foodborne mycotoxins through gut microbiota: A comprehensive review

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