Effects of prism adaptation on motor-intentional spatial bias in neglect

Fortis, Paola; Chen, Peii; Goedert, Kelly M.; Barrett, Anna M.

doi:10.1097/wnr.0b013e32834a3e20

Cited by 59 publications

(71 citation statements)

References 24 publications

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“…19,20 Even in responsive patients, PAT may not ameliorate all neglect symptoms: this may be related to a specific effect of PAT on Aiming, but not Where, bias. 6,18,21 Using a computerized line bisection task that separately quantifies Where and Aiming spatial biases, 22 we demonstrated that five participants with left neglect experienced an improvement in Aiming bias after two sessions of PAT, with no reliable change in Where bias. 18 This specific effect of prism adaptation on Aiming bias was also observed in a large group of neurologically healthy individuals.…”

Section: Introductionmentioning

confidence: 78%

“…These results are consistent with prior work demonstrating that PAT improved Aiming, but not Where, spatial dysfunction. 18 …”

Section: Discussionmentioning

confidence: 99%

“…Under reversed conditions, visual feedback was left-right reversed, such that rightward movements of the mouse resulted in leftward movements of the cursor and vice versa. This task has demonstrated research utility and construct validity to assess Where and Aiming bias in neglect patients 10,18 and healthy controls. 22,29 Participants’ line bisection error across 16 normal and reversed trials was averaged and fractionated into Where and Aiming components (mm equivalents) as follows: 10,18,21,22,29 …”

Section: Methodsmentioning

confidence: 99%

“…13–18 Nevertheless, not all efficacy studies reported that neglect improved with prism treatment. 19,20 Even in responsive patients, PAT may not ameliorate all neglect symptoms: this may be related to a specific effect of PAT on Aiming, but not Where, bias.…”

Section: Introductionmentioning

confidence: 99%

“…The Behavioral Inattention Test (BIT) 23 and the Catherine Bergego Scale (CBS) 24,25 were administered weekly thereafter for a total of six follow-up assessments. Because prism adaptation may specifically target Aiming bias in neglect, 18,21 we hypothesized that participants with Aiming deficits would show greater improvement than those with isolated Where deficits.…”

Section: Introductionmentioning

confidence: 99%

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Presence of Motor-Intentional Aiming Deficit Predicts Functional Improvement of Spatial Neglect With Prism Adaptation

Goedert

Chen

Boston

et al. 2013

Neurorehabil Neural Repair

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Spatial neglect is a debilitating disorder for which there is no agreed upon course of rehabilitation. The lack of consensus on treatment may result from systematic differences in the syndromes’ characteristics, with spatial cognitive deficits potentially affecting perceptual-attentional Where or motor-intentional Aiming spatial processing. Heterogeneity of response to treatment might be explained by different treatment impact on these dissociated deficits: prism adaptation, for example, might reduce Aiming deficits without affecting Where spatial deficits. Here, we tested the hypothesis that classifying patients by their profile of Where-vs-Aiming spatial deficit would predict response to prism adaptation, and specifically that patients with Aiming bias would have better recovery than those with isolated Where bias. We classified the spatial errors of 24 sub-acute right-stroke survivors with left spatial neglect as: 1) isolated Where bias, 2) isolated Aiming bias or 3) both. Participants then completed two weeks of prism adaptation treatment. They also completed the Behavioral Inattention Test (BIT) and Catherine Bergego Scale (CBS) tests of neglect recovery weekly for six weeks. As hypothesized, participants with only Aiming deficits improved on the CBS, whereas, those with only Where deficits did not improve. Participants with both deficits demonstrated intermediate improvement. These results support behavioral classification of spatial neglect patients as a potential valuable tool for assigning targeted, effective early rehabilitation.

show abstract

Section: Introductionmentioning

confidence: 78%

“…These results are consistent with prior work demonstrating that PAT improved Aiming, but not Where, spatial dysfunction. 18 …”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Presence of Motor-Intentional Aiming Deficit Predicts Functional Improvement of Spatial Neglect With Prism Adaptation

Goedert

Chen

Boston

et al. 2013

Neurorehabil Neural Repair

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Neuropsychological Rehabilitation

Champod¹,

Eskes²,

Barrett³

2020

Neurovascular Neuropsychology

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Integrity of medial temporal structures may predict better improvement of spatial neglect with prism adaptation treatment

Chen

Goedert

Shah

et al. 2012

Brain Imaging and Behavior

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Prism adaptation treatment (PAT) is a promising rehabilitative method for functional recovery in persons with spatial neglect. Previous research suggests that PAT improves motor-intentional “aiming” deficits that frequently occur with frontal lesions. To test whether presence of frontal lesions predicted better improvement of spatial neglect after PAT, the current study evaluated neglect-specific improvement in functional activities (assessment with the Catherine Bergego Scale) over time in 21 right-brain-damaged stroke survivors with left-sided spatial neglect. The results demonstrated that neglect patients' functional activities improved after two weeks of PAT and continued improving for four weeks. Such functional improvement did not occur equally in all of the participants: Neglect patients with lesions involving the frontal cortex (n=13) experienced significantly better functional improvement than did those without frontal lesions (n=8). More importantly, voxel-based lesion-behavior mapping (VLBM) revealed that in comparison to the group of patients without frontal lesions, the frontal-lesioned neglect patients had intact regions in the medial temporal areas, the superior temporal areas, and the inferior longitudinal fasciculus. The medial cortical and subcortical areas in the temporal lobe were especially distinguished in the “frontal lesion” group. The findings suggest that the integrity of medial temporal structures may play an important role in supporting functional improvement after PAT.

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Effects of prism adaptation on motor-intentional spatial bias in neglect

Cited by 59 publications

References 24 publications

Presence of Motor-Intentional Aiming Deficit Predicts Functional Improvement of Spatial Neglect With Prism Adaptation

Presence of Motor-Intentional Aiming Deficit Predicts Functional Improvement of Spatial Neglect With Prism Adaptation

Neuropsychological Rehabilitation

Integrity of medial temporal structures may predict better improvement of spatial neglect with prism adaptation treatment

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