Integrity of medial temporal structures may predict better improvement of spatial neglect with prism adaptation treatment

Chen, Peii; Goedert, Kelly M.; Shah, Priyanka; Foundas, Anne L.; Barrett, Anna M.

doi:10.1007/s11682-012-9200-5

Cited by 44 publications

(58 citation statements)

References 88 publications

(134 reference statements)

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“…We identified five anatomical studies on patients in the acute stage of stroke recovery from contralesional neglect (Leibovitch et al, 1998; Karnath, Himmelbach & Rorden, 2002; Mort et al, 2003; Karnath, Renning, Johannsen & Rorden, 2011; Chen, Goedert, Shah, Foundas & Barrett, 2012). Using the weighted average of these five studies may not be the best comparison to our ipsilesional neglect sample because of differences in the exclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Using the weighted average of these five studies may not be the best comparison to our ipsilesional neglect sample because of differences in the exclusion criteria. Thus, we completed a Chi-square goodness-of- fit analysis excluding the two studies conducted by Karnath and colleagues (Karnath, Himmelbach & Rorden, 2002; Karnath, Renning, Johannsen & Rorden, 2011), because unlike our participant sample and those of the Leibovitch et al (1988), Mort et al (2003), and Chen et al (2012) studies, the Karnath studies excluded individuals with visual field deficits. The weighted average proportion of contralesional patients with frontal or subcortical damage from these three studies was 0.3471.…”

Section: Resultsmentioning

confidence: 99%

“…Participants in this dataset had unilateral right hemisphere brain damage, with no history of dementia, uncontrolled glaucoma, or previous head trauma with loss of consciousness (data on subsets of the patients with contralesional neglect in this dataset have previously been published; Chen et al, 2012; Goedert et al, 2012, 2013). All 132 patients were evaluated with the Mini-Mental Status Examination (MMSE; Folstein, Folstein, & McHugh, 1975), Behavioural Inattention Test (BIT; Wilson, Cockburn & Halligan, 1987), Catherine Bergego Scale (CBS; Azouvi, Olivier, Montety, Samuel, Louis-Dreyfus & Tesio, 2003) and Barthel Index (Mahoney & Barthel, 1965).…”

Section: Methodsmentioning

confidence: 99%

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Ipsilesional neglect: Behavioral and anatomical correlates.

Sacchetti¹,

Goedert²,

Foundas³

et al. 2015

Neuropsychology

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Objective The sparse existing research on ipsilesional neglect supports an association of this disorder with damage to the right frontal and subcortical brain networks. It is believed that dysfunction in these networks may result in primarily “aiming”, motor-intentional spatial errors. The purpose of this study was to confirm whether frontal-subcortical circuits are indeed commonly affected in ipsilesional neglect and to determine the relative presence of “aiming”, motor-intentional versus “where”, perceptual-attentional spatial errors in these individuals. Methods We identified 12 participants with ipsilesional neglect based on a computerized line bisection task and used the line bisection data to quantify participants' perceptual-attentional and motor-intentional errors. We were able to discriminate between these two biases using the algebraic solutions for two separate equations, one for “aiming” and one for “where” biases. Lesion mapping was conducted for all participants using MRICroN® software; lesion checklist and overlap analysis were created from these images. Results A greater percentage of participants with ipsilesional neglect had frontal/subcortical damage (83%) compared to the expected percentage (27%) observed in published patient samples with contralesional neglect. We observed the greatest area of lesion overlap in frontal lobe white matter pathways. Nevertheless, participants with ipsilesional neglect made primarily “where” rather than “aiming” spatial errors. Conclusion Our data confirms previous research suggesting that ipsilesional neglect may result from lesions to the right frontal-subcortical networks. Furthermore, in our group, ipsilesional neglect was also strongly associated with primarily “where”, perceptual-attentional bias, and less so with “aiming” motor-intentional spatial bias.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Ipsilesional neglect: Behavioral and anatomical correlates.

Sacchetti¹,

Goedert²,

Foundas³

et al. 2015

Neuropsychology

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“…Medial temporal structures play an important role in supporting functional improvement after prism adaptation treatment [46] and anterior cerebellar cortex in computation or compensation of ipsidirectional visual error [47]. Moreover, severe occipital lesions were associated with a lack of error reduction, poor neglect recovery and reduced oculo-motor system amelioration [43].…”

Section: Differences Between Enrolled Patientsmentioning

confidence: 99%

Efficacy of Prisms in Neglect Treatment: A Randomized Single Blind Study

Mancuso¹,

Capitani²

2016

Int J Phys Med Rehabil

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Objective: Unilateral Spatial Neglect (USN) commonly occurs after lesions in the right hemisphere. This complex syndrome can be defined as a failure to report, respond, or orient to contralateral stimuli. Patients show several symptoms in everyday life, such as eating only on the right side of the plate, or forgetting to look left before crossing the street.Among the different bottom-up treatments, prisms adaptation has found considerable application, producing a high number of scientific papers, even if these are not always consistent in their conclusions.The aim of this randomized single blind study was to verify the efficacy of prisms in improving neglect syndrome when compared to neutral lenses in a group of stroke in patients with neglect.Methods: All patients were randomized into two groups: Experimental Group (EG) and Control Group (CG). The EG was treated with pointing exercises wearing prismatic lenses producing a deviation of the visual field of 10° to the right, while the CG was treated with pointing exercises wearing neutral lenses that did not produce any deviation of the visual field. Both groups were treated for two weeks.We compared with Analysis of Variance the two groups of stroke patients at two different treatment times, at the enrollment time (T0) and after two weeks (T1). Results:We have compared the EG and CG at T0 and T1 time: both groups show a significant improvement in outcome measure. The analysis between groups highlights that this effect can be related to the time rather than to the group of treatment. Conclusion:According to our results we can conclude that pointing with no visible arm is useful in neglect treatment and that prisms produce some further benefits even if the low number of subjects enrolled is still insufficient to give clear evidence in the use of prisms.

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“…Secondly, USN is a heterogeneous disorder and some tests fail to detect specific aspects of neglect [10,17]. Thirdly, from several researches there are suggestions of the need of more behavioural tests to evaluate the treatment outcomes [18][19][20], because in some cases the conventional and behavioural evaluations may dissociate [21].…”

Section: Introductionmentioning

confidence: 99%

Normative data for distal line bisection and baking tray task

Facchin

Beschin²,

Pisano

et al. 2016

Neurol Sci

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Line bisection is one of the tests used to diagnose unilateral spatial neglect (USN). Despite its wide application, no procedure or norms were available for the distal variant when the task was performed at distance with a laser pointer. Furthermore, the baking tray task was an ecological test aimed at diagnosing USN in a more natural context. The aim of this study was to collect normative values for these two tests in an Italian population. We recruited a sample of 191 healthy subjects with ages ranging from 20 to 89 years. They performed line bisection with a laser pointer on three different line lengths (1, 1.5, and 2 m) at a distance of 3 m. After this task, the subjects performed the baking tray task and a second repetition of line bisection to test the reliability of measurement. Multiple regression analysis revealed no significant effects of demographic variables on the performance of both tests. Normative cut-off values for the two tests were developed using non-parametric tolerance intervals. The results formed the basis for clinical use of these two tools for assessing lateralized performance of patients with brain injury and for diagnosing USN.

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Integrity of medial temporal structures may predict better improvement of spatial neglect with prism adaptation treatment

Cited by 44 publications

References 88 publications

Ipsilesional neglect: Behavioral and anatomical correlates.

Ipsilesional neglect: Behavioral and anatomical correlates.

Efficacy of Prisms in Neglect Treatment: A Randomized Single Blind Study

Normative data for distal line bisection and baking tray task

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