Effects of Pretraining Intrastriatal Administration of p-Chloroamphetamine on Inhibitory Avoidance

The Role of Muscarinic and Nicotinic Cholinergic Neurotransmission in Aversive Conditioning: Comparing Pavlovian Fear Conditioning and Inhibitory Avoidance

“…Salado-Castillo et al (1996) demonstrated that posttraining infusion of GABAergic drugs into various regions of the dorsal striatum interfered with memory consolidation following inhibitory avoidance training. Similar effects have been found recently following a variety of serotonergic manipulations (Solana-Figueroa et al 2002;Prado-Alcala et al 2003a,b). The effects of intrastriatal cholinergic manipulations on inhibitory avoidance will be discussed below.…”

Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats

“…In two recent studies it was found that intrastriatal infusions of PCA (Solana-Figueroa et al, 2002a) and serotonin (Prado-Alcalá et al, 2003) also produced marked retention deficits of inhibitory avoidance. In these cases, both serotonin released by PCA and direct infusion of serotonin should have activated 5-HT2 receptors.…”

“…Congruent with this expectation, we have recently reported that indeed, intrastriatal administration of PCA produces a marked deficit in retention of inhibitory avoidance (Solana-Figueroa et al, 2002a). Furthermore, activation of intrastriatal 5-HT receptors, induced by infusion of serotonin itself, has the same detrimental effect (Prado-Alcalá et al, 2003).…”

“…In spite of the abundant literature regarding the effects of systemic administration of serotonergic drugs on memory (e.g., Altman and Normile, 1987;Archer, 1982;Meneses, 1999Meneses, , 2002Misane et al, 1998;Ö gren, 1982, 1986aSolana-Figueroa et al, 1999, 2002b, there is a conspicuous scarcity of reports regarding the cognitive effects of their central administration. It is reasonable to postulate that serotonin (5-HT) must interact with other neurotransmitters in those cerebral regions known to participate in cognition.…”

Impaired Object Recognition Memory Following Methamphetamine, but not p-Chloroamphetamine- or d-Amphetamine-Induced Neurotoxicity

“…Animals given a neurotoxic regimen of either PCA (a drug that causes long-lasting depressions in serotonergic, but not dopaminergic terminal markers), or d-AMPH (a drug that causes enduring losses in markers of dopaminergic, but not serotonergic terminals), were unimpaired in the task of OR. Although there is a large body of research investigating the PCA-induced impairments, most of these studies examined behavioral changes immediately after PCA administration (Solana-Figueroa et al, 2002;Archer et al, 1982;Ö gren, 1982). Ruotsalainen et al (2000) report mild impairments in response inhibition in animals 3 weeks following a neurotoxic regimen of PCA, but no impairment in a 5-choice serial reaction time task of attention.…”