Effects of prepartum zinc-methionine supplementation on feed digestibility, rumen fermentation patterns, immunity status, and passive transfer of immunity in dairy cows

Chen, Fengting; Li, Yan; Shen, Yizhao; Guo, Yanfei; Li, Qiufeng; Cao, Yong; Zhang, Xiujiang; Li, Yunqi; Wang, Zhonghua; Gao, Yanxia; Li, Jianguo

doi:10.3168/jds.2019-17991

Cited by 18 publications

(18 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ZM supplementation reportedly enhanced the resistance to infection by increasing the total immunoglobulin concentration in weaning calves (29). In addition, a recent study demonstrated that ZM supplementation increased the concentrations of IgA and IgM in the colostrum of dairy cows (33). In the present study, we found that not only ZM, but also ZP increased the plasma IgG concentrations.…”

Section: Discussionsupporting

confidence: 72%

“…Researches have shown that zinc suppresses pro-inflammatory cytokines production, whereas zinc deficiency induces the production of pro-inflammatory cytokines such as IL-1β and IL-6 (35). Chen et al (33) suggested that the blood concentration of IL-1 in dairy cows decreased linearly, with the dose of ZM increasing. So far, there are few studies on the effect of ZP on plasma cytokines.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Supplementation With Zinc Proteinate Increases the Growth Performance by Reducing the Incidence of Diarrhea and Improving the Immune Function of Dairy Calves During the First Month of Life

Jin

Gao

et al. 2022

Front. Vet. Sci.

View full text Add to dashboard Cite

Two experiments were conducted to identify the optimal dose of zinc proteinate (ZP) in the diet for dairy calves and then to compare early supplementation with the ZP or zinc methionine (ZM) on the growth performance, incidence of diarrhea, antioxidant status, and immune function of dairy calves during their first month of life. In Experiment 1, forty newborn female Holstein dairy calves were randomly divided into four groups (n = 10): a control group (without ZP supplementation, ZP0) or groups that received ZP supplementation at 40, 80, and 120 mg zinc/day, respectively (ZP40, ZP80, and ZP120). The experiment lasted 14 days, and the growth performance, incidence of diarrhea, and serum zinc concentration were analyzed. In Experiment 2, thirty-six newborn female Holstein dairy calves were randomly allocated to three groups (n = 12): a negative control group (without zinc supplementation, CON), a positive control group (supplemented with 80 mg zinc/day in the form of zinc methionine, ZM), and a ZP group (supplemented with 80 mg zinc/day in the form of ZP). The experiment lasted 28 days, and the growth performance, incidence of diarrhea, serum zinc concentration, serum antioxidant indicators, and concentrations of plasma immunoglobulins and cytokines were determined on days 7, 14, 21, and 28. Results showed that in Experiment 1, supplementation with ZP to yield 80 mg zinc/day increased the ADG (P < 0.01) and serum zinc concentration (P < 0.01), and decreased the F/G (P < 0.01) and the incidence of diarrhea (P < 0.05) during days 1–14. In Experiment 2, compared with the CON group, ZP increased the ADG (P < 0.01), serum zinc concentration (P < 0.01), and plasma immunoglobulin G (IgG; P < 0.01) and IgM (P < 0.01) concentrations, but reduced the incidence of diarrhea (P < 0.01), serum malondialdehyde (P < 0.01), and plasma interleukin-1β (P < 0.01) concentrations during days 1–28. Overall, ZP supplementation to yield 80 mg zinc/day improves the growth performance and immune function, and decrease the incidence of diarrhea of dairy calves, which was comparable to the same dose of zinc in the form of ZM.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Supplementation With Zinc Proteinate Increases the Growth Performance by Reducing the Incidence of Diarrhea and Improving the Immune Function of Dairy Calves During the First Month of Life

Jin

Gao

et al. 2022

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…tion period, whereas in our study we performed total replacement of STM by OTM sources in both pre-and postpartum TMRs. Chen et al (2020) reported that supplementation of Zn-methionine given to prepartum cows increased DMI linearly, with increasing inclusion levels from 0 to 60 mg/kg of DM. Changes in feed intake are normally accompanied by changes in feeding behavior.…”

Section: Discussionmentioning

confidence: 99%

Effects of replacing inorganic salts of trace minerals with organic trace minerals in pre- and postpartum diets on feeding behavior, rumen fermentation, and performance of dairy cows

Mion

Winters

King

et al. 2022

Journal of Dairy Science

View full text Add to dashboard Cite

Our objectives were to evaluate the effects of complete replacement of supplementary inorganic salts of trace minerals (STM) by organic trace minerals (OTM) in both pre-and postpartum diets on feeding behavior, ruminal fermentation, rumination activity, energy metabolism, and lactation performance in dairy cows. Pregnant cows and heifers (n = 273) were blocked by parity and body condition score and randomly assigned to either STM or OTM diets at 45 ± 3 d before their expected calving date. Both groups received the same diet, except for the source of trace minerals (TM). The STM group was supplemented with Co, Cu, Mn, and Zn sulfates and Na selenite, whereas the OTM group was supplemented with Co, Cu, Mn, and Zn proteinates and selenized yeast. Treatments continued until 156 days in milk and pre-and postpartum diets were formulated to meet 100% of recommended levels of each TM in both treatments, taking into consideration both basal and supplemental levels. Automatic feed bins were used to assign treatments to individual cows and to measure feed intake and feeding behavior. Rumination activity was monitored by sensors attached to a collar from wk −3 to 3 relative to calving. Blood metabolites were evaluated on d −21, −10, −3, 0, 3, 7, 10, 14, 23, and 65 relative to calving. Ruminal fluid samples were collected using an ororuminal sampling device on d −21, 23, and 65 relative to calving, for measurement of ruminal pH and concentration of volatile fatty acids. Cows were milked twice a day and milk components were measured monthly. Cows supplemented with OTM tended to have longer daily feeding time (188 vs. 197 min/d), and greater dry matter intake (DMI; 12.9 vs. 13.3 kg), and had a more positive energy balance (3.6 vs. 4.2 Mcal/d) and shorter rumination time per kg of dry matter (DM; 40.1 vs. 37.5 min/kg of DM) than cows supplemented with STM during the prepartum period. In the postpartum period, OTM increased DMI in multiparous cows (24.1 vs. 24.7 kg/d) but not in primiparous cows (19.1 vs. 18.7 kg/d). The difference in DMI of multiparous cows was more evident in the first 5 wk of lactation, when it averaged 1 kg/d. Milk yield was not affected by treatment in multiparous cows (44.1 vs. 44.2 kg/d); however, primiparous cows supplemented with OTM had lesser yields than primiparous cows supplemented with STM (31.9 vs. 29.8 kg/d). Cows supplemented with OTM had a greater percentage of protein in milk (3.11 vs. 3.17%), reduced concentration of nonesterified fatty acids in serum (0.45 vs. 0.40 mmol/L), and rumination activity (30.1 vs. 27.8 min/kg of DM) than cows supplemented with STM. At the end of the transition period, cows supplemented with OTM had reduced molar proportion of acetate, reduced pH, and tended to have a greater concentration of total volatile fatty acids in ruminal fluid. In conclusion, complete replacement of STM by OTM caused modest changes in rumen fermentation, feeding behavior, energy metabolism, and performance of dairy cows, improving postpartum DMI in multiparous cows and reducing circulating l...

show abstract

“…Supplementing a diet with Zn vs. no supplemental Zn has previously been shown to increase dietary N digestibility or retention in some studies ( Carmichael et al, 2018 , 2019 ; Alijani et al, 2020 ). However, the majority of studies showed no effect of Zn sources on N digestibility and retention ( Pino and Heinrichs, 2016 ; Faulkner and Weiss, 2017 ; Alijani et al, 2020 ; Chen et al, 2020 ). Nevertheless, Daniel et al (2020) observed that dietary CP digestibility decreased by a 1% unit when an organic form of Cu, Mn, and Zn (proteinate) replaced 30% of the inorganic form of these minerals.…”

Section: Discussionmentioning

confidence: 99%

Effect of zinc sources and experimental conditions on zinc balance in growing wethers

Lee

Copelin

Socha

2022

Translational Animal Science

View full text Add to dashboard Cite

Three experiments were conducted with growing wethers to evaluate apparent excretion and retention of Zn from various sources. In Exp. 1 and 2, Zn-ethylene diamine (ZE), Zn hydroxychloride (ZHYD), Zn-lysine/glutamate (ZAA), and Zn-glycinate (ZG) were used and ZnSO4 (ZS), Zn hydroxychloride (ZHYD), Zn-lysine/glutamate (ZAA), and Zn-glycinate (ZG) were used in Exp. 3. In Exp. 1, 8 wethers were used in a replicated 4 × 4 Latin Square design. In Exp. 2 and 3, 40 wethers were used in a randomized block design. In Exp. 1, each period (total 4 periods) consisted of 14-day diet adaptation and 4 days of total collection of feces and urine. In Exp. 2 and 3, wethers received a basal diet for 14 days and received experimental diets for 9 days (diet adaptation), followed by 4 days of total collection of feces and urine. Total collection was conducted in wooden metabolic cages. All data were analyzed using the MIXED procedure of SAS as a Latin square design for Exp. 1 and a completed randomized block design for Exp. 2 and 3. In all experiments, dry matter intake did not differ among treatments except that it tended to be different in Exp. 2. In Exp. 1, no difference in Zn excretion (88%) and retention (11%) as proportion of Zn intake was observed among Zn sources. In Exp. 2, total tract digestibility of crude protein was greater (P < 0.01) for ZAA than ZE and ZG (82.0 vs. 79.1 and 77.8%, respectively) and greater (P < 0.01) for ZHYD than ZG (80.2 vs. 77.8%). However, total tract digestibility of neutral detergent fiber was low (on average 16%) for all treatments with no difference among treatments in Exp. 2. Apparent excretion and retention of Zn as proportion of Zn intake did not differ among treatments, and Zn retention (~1.4% of Zn intake) was very low for all treatments. In Exp. 3, ZHYD and ZAA had greater retention of Zn (17.8 vs. 1.5%; P = 0.01) than ZG. Fecal Zn excretion was greater (97.3 vs. 81.2%; P = 0.01) for ZG vs. ZHYD and ZAA, and Zn retention for ZG was only 1.5% of Zn intake. In conclusion, potential increases in Zn absorption and retention were observed for ZHYD and ZAA compared with ZS and ZG in Exp. 3 and these differences were not found in Exp. 1 and 2. Experiment 1 used a Latin square design and Exp. 2 used a diet containing largely undigestible fiber. These experimental conditions may have affected Zn metabolism in wethers. Inconsistent results on Zn balance for ZG among the experiments warrant further studies regarding its bioavailability.

show abstract

Effects of prepartum zinc-methionine supplementation on feed digestibility, rumen fermentation patterns, immunity status, and passive transfer of immunity in dairy cows

Cited by 18 publications

References 45 publications

Supplementation With Zinc Proteinate Increases the Growth Performance by Reducing the Incidence of Diarrhea and Improving the Immune Function of Dairy Calves During the First Month of Life

Supplementation With Zinc Proteinate Increases the Growth Performance by Reducing the Incidence of Diarrhea and Improving the Immune Function of Dairy Calves During the First Month of Life

Effects of replacing inorganic salts of trace minerals with organic trace minerals in pre- and postpartum diets on feeding behavior, rumen fermentation, and performance of dairy cows

Effect of zinc sources and experimental conditions on zinc balance in growing wethers

Contact Info

Product

Resources

About