Effects of preparation conditions on the monodispersity of albumin microspheres

El-Mahdy, M.; Ibrahim, E. S.; Safwat, S. M.; El‐Sayed, Amr; Ohshima, Hiroyuki; Makino, Kimiko; Muramatsu, Nobuhiro; Kondo, Tamotsu

doi:10.3109/02652049809008248

Cited by 32 publications

(13 citation statements)

References 27 publications

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“…8 shows PDVB spacers for LCDs, manufactured by Sekisui Chemical Industries Co. Ltd. using a SPG membrane emulsification technique [34]. Figure 9 shows an example of manufacture of quite large polymer beads (in the size range 80-500 µm) manufactured using an interfacial polymerisation method [15,51]. In this case the membrane used was stainless steel perforated with approximately circular pores of 140 microns in diameter.…”

Section: Production Of Polymer Microspheresmentioning

confidence: 99%

Recent developments in manufacturing emulsions and particulate products using membranes

Vladisavljević

Williams

2005

Advances in Colloid and Interface Science

323

196

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Membrane emulsification is a relatively new technique for the highly controlled production of particulates. This review focuses on the recent developments in this area, ranging from the production of simple oil-in-water (O/W) or water-in-oil (W/O) emulsions to multiple emulsions of different types, solid-in-oil-in-water (S/O/W) dispersions, coherent solids (silica particles, solid lipid microspheres, solder metal powder), and structured solids (solid lipid microcarriers, gel microbeads, polymeric microspheres, core-shell microcapsules and hollow polymeric microparticles). Other emerging technologies that extend the capabilities into different membrane materials and operation methods (such as rotating membranes, repeated membrane extrusion of coarsely pre-emulsified feeds) are introduced. The results of experimental work carried out by cited researchers in the field together with those of the current authors are presented in a tabular form in a rigorous and systematic manner. These demonstrate a wide range of products that can be manufactured using different membrane approaches. Opportunities for creation of new and novel entities are highlighted for low throughput applications (medical diagnostics, healthcare) and for large scale productions (consumer and personal products).

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Section: Production Of Polymer Microspheresmentioning

confidence: 99%

Recent developments in manufacturing emulsions and particulate products using membranes

Vladisavljević

Williams

2005

Advances in Colloid and Interface Science

323

196

View full text Add to dashboard Cite

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“…The size distribution was estimated with the SPAN (size distribution) factor (EI-Mahdy et al, 1998), which is defined as Eq. (1):…”

Section: Characterization Of the Size And Size Distribution Of Calciumentioning

confidence: 99%

Microencapsulated probiotics using emulsification technique coupled with internal or external gelation process

Song

Gao

et al. 2013

Carbohydrate Polymers

117

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“…values related to the mean. Polydispersity was determined by the SPAN factor (El-Mahdy et al, 1998) (v, 50), where D(v, 90), D(v, 10) and D(v, 50) are volume size diameters at 90, 10 and 50% of the cumulative volume, respectively. A high value of SPAN indicates a wide distribution in size and a high polydispersity.…”

Section: Morphological and Particle Size Analysismentioning

confidence: 99%

Alginate microspheres prepared by internal gelation: Development and effect on insulin stability

Silva

Ribeiro

Figueiredo

et al. 2006

International Journal of Pharmaceutics

184

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Recombinant human insulin was encapsulated within alginate microspheres by the emulsification/internal gelation technique with the objective of preserving protein stability during encapsulation procedure. The influence of process and formulation parameters was evaluated on the morphology and encapsulation efficiency of insulin. The in vitro release of insulin from microspheres was studied under simulated gastrointestinal conditions and the in vivo activity of protein after processing was assessed by subcutaneous administration of extracted insulin from microspheres to streptozotocin-induced diabetic rats. Microspheres mean diameter, ranging from 21 to 287 m, decreased with the internal phase ratio, emulsifier concentration, mixer rotational speed and increased with alginate concentration. Insulin encapsulation efficiency, near 75%, was not affected by emulsifier concentration, mixer rotational speed and zinc/insulin hexamer molar ratio but decreased either by increasing internal phase ratio and calcium/alginate mass ratio or by decreasing acid/calcium molar ratio and alginate concentration. A high insulin release, above 75%, was obtained at pH 1.2 and under simulated intestinal pH a complete dissolution of microspheres occurred. Extracted insulin from microspheres decreased hyperglycemia of diabetic rats proving to be bioactive and showing that encapsulation in alginate microspheres using the emulsification/internal gelation is an appropriate method for protein encapsulation.

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Effects of preparation conditions on the monodispersity of albumin microspheres

Cited by 32 publications

References 27 publications

Recent developments in manufacturing emulsions and particulate products using membranes

Recent developments in manufacturing emulsions and particulate products using membranes

Microencapsulated probiotics using emulsification technique coupled with internal or external gelation process

Alginate microspheres prepared by internal gelation: Development and effect on insulin stability

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