2006
DOI: 10.1016/j.ijpharm.2005.10.050
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Abstract: Recombinant human insulin was encapsulated within alginate microspheres by the emulsification/internal gelation technique with the objective of preserving protein stability during encapsulation procedure. The influence of process and formulation parameters was evaluated on the morphology and encapsulation efficiency of insulin. The in vitro release of insulin from microspheres was studied under simulated gastrointestinal conditions and the in vivo activity of protein after processing was assessed by subcutaneo… Show more

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Cited by 177 publications
(99 citation statements)
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“…The control of particles size remains a main challenge but the retention of biological activity of encapsulant has been reported (Silva, Ribeiro, Figueiredo, Goncalves, & Veiga, 2006). Differential scanning calorimetry (DSC) can be used to characterize the thermal behaviour of polyelectrolytes and biomolecules which is correlated to their structure, hydrophilic properties and association state.…”
Section: Introductionmentioning
confidence: 99%
“…The control of particles size remains a main challenge but the retention of biological activity of encapsulant has been reported (Silva, Ribeiro, Figueiredo, Goncalves, & Veiga, 2006). Differential scanning calorimetry (DSC) can be used to characterize the thermal behaviour of polyelectrolytes and biomolecules which is correlated to their structure, hydrophilic properties and association state.…”
Section: Introductionmentioning
confidence: 99%
“…It could be achieved by altering the formulation variables like process or concentration (independent variables), which eventually escalate end-user (Silva et al, 2006), Improved proteolytic stability (Bowey et al, 2012), Oral/nasal delivery Zhang et al, 2011), Protection from acidic pH of stomach (Leong et al, 2011) Preserved the bio-stability during the preparation process, reduced injection site reactions and transient nausea (Ryan et al, 2013).…”
Section: Designing and Development Of Novel Drug Delivery Systemsmentioning
confidence: 99%
“…It is obtained from marine brown algae and has the ability to form a gel network in the presence of divalent cations such as calcium in aqueous media. Thus, alginate beads are successfully prepared by ionotropic gelation [9,10]. More effective beads for the controlled release of drugs can be prepared using the combination of chitosan and alginate.…”
Section: Introductionmentioning
confidence: 99%