Effects of prenatal nicotine exposure on rat striatal dopaminergic and nicotinic systems

Fung, Yiu K.; Lau, Yuen-Sum

doi:10.1016/0091-3057(89)90419-x

Cited by 90 publications

(39 citation statements)

References 29 publications

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“…Decreases in birth weight have been reported from animal studies using daily doses of 6 to 9 mg/kg/day nicotine via continuous infusion (Cutler et al 1996;Richardson and Tizabi 1994;Tizabi et al 2000;Vaglenova et al 2004), which produces venous serum nicotine levels higher than in most smokers. Other studies using s.c. injections or a continuous nicotine infusion that delivered a daily dose similar to or higher than that in the present study (1.5 to 5 mg/kg/day) have generally found no effect on birth weight (Fung and Lau 1989;Johns et al 1993;Levin et al 1993;Romero and Chen 2004;Shacka et al 1997;Sobrian et al 2003). Thus the reduced birth weight observed with a relatively low daily nicotine dose in the present study suggests that prenatal nicotine treatment may be more potent when administered via repeated i.v.…”

Section: Discussionmentioning

confidence: 35%

“…Numerous studies have shown a wide range of behavioral impairments in rodents prenatally exposed to nicotine, including impaired performance in the radial arm maze and Morris water maze (Levin et al 1993;Sorenson et al 1991;Yanai et al 1992), lower response and reinforcement rates under operant schedules of food delivery (Martin and Becker 1971), poorer operant discrimination performance (Martin and Becker 1971), and reduced pre-pulse inhibition of acoustic startle response . Although several animal studies have found that offspring prenatally exposed to nicotine can also exhibit hyperactivity (Ajarem and Ahmad 1998;Fung and Lau 1989;Martin and Becker 1970;Peters et al 1979;Vaglenova et al 2004), other studies have reported conflicting results (see Table 1). Some studies report hyperactivity in only a subset of rats (less than 20%), with no significant overall effect of prenatal nicotine exposure (Richardson and Tizabi 1994;Tizabi et al 1997).…”

Section: Introductionmentioning

confidence: 83%

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Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

LeSage

Gustaf

Dufek

et al. 2006

Pharmacology Biochemistry and Behavior

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Maternal tobacco use is associated with adverse developmental outcomes in offspring, including hyperactivity. Animal studies attempting to model this phenomenon have primarily used continuous s.c. nicotine infusion as the method of nicotine administration, which does not model the intermittent bolus delivery of nicotine associated with smoking in humans. The purpose of the present experiment was to examine the locomotor activity of pre-weanling offspring of pregnant rats exposed to an i.v. nicotine dosing protocol that approximates the pattern of nicotine exposure in moderate to heavy smokers. Pregnant rats were administered an i.v. bolus of 0.03 mg/kg nicotine (N=13) or saline (N=10) every 14 min for 16 hr/day, resulting in a total daily dose of 2 mg/kg (base), from gestational day 4 to delivery. Pups from each litter were tested for spontaneous locomotor activity on postnatal days (PND) 19-21 and nicotine-induced locomotor activity on PND 22. Mean birth weight was significantly lower in nicotine-exposed pups compared to controls, but body weights were equivalent between groups by the time of behavioral testing. Mean total distance traveled, vertical counts, and stereotypy counts were lower on PND 19 in nicotine-exposed pups compared to controls, but only the difference in mean stereotypy counts was statistically significant. Within session analysis revealed that both distance traveled and stereotypy were significantly decreased in nicotine-exposed pups in the first five minutes of the session on PND 19. Total time spent in the center of the field was also lower in nicotine exposed pups. Nicotine-induced increases in activity on PND 22 did not differ according to gestational exposure. These findings demonstrate that prenatal nicotine exposure in a model that mimics the pattern of nicotine exposure from cigarette smoking in humans results in offspring that exhibit low birth weight and hypoactivity in a novel environment.

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Section: Discussionmentioning

confidence: 35%

Section: Introductionmentioning

confidence: 83%

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

LeSage

Gustaf

Dufek

et al. 2006

Pharmacology Biochemistry and Behavior

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“…This dose of nicotine is estimated to be roughly comparable to a human smoking four cigarettes per day (Levin, Wilkerson, Jones, Christopher, & Briggs, 1996; see also Fung &Lau, 1989, andMurrin, Ferrer, Zeng, &Haley, 1987). All injections were performed in a small room near the animal colony facilities and were given approximately 2-3 hr after the onset of the light phase.…”

Section: Nicotine Administrationmentioning

confidence: 99%

Differential Effects of Nicotine and Complex Housing on Subsequent Experience-Dependent Structural Plasticity in the Nucleus Accumbens.

Hamilton¹,

Kolb²

2005

Behavioral Neuroscience

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Drugs and other forms of experience (e.g., complex housing) share the ability to alter the dendritic fields of cortical and subcortical neurons. Although such modifications are typically considered advantageous, recent research has demonstrated that psychomotor stimulants (cocaine and amphetamine) block subsequent experience-dependent structural plasticity in the nucleus accumbens (NAcc) and parietal neocortex. The authors investigated whether these findings generalize to another commonly used stimulant (nicotine) and further asked whether prior experience blocks subsequent nicotine-related structural plasticity. Rats were given daily injections of nicotine (or saline) for 14 days either before (Experiment 1) or after (Experiment 2) 2.5-3.0 months of complex (or standard) housing. Nicotine blocked housing-related increases in dendritic branching, length, spine density, and total spines in NAcc; however, complex housing did not block the effects of nicotine. The findings indicate that there are important differences in the capacity of drugs and experience to influence subsequent modifications in dendritic structure.

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“…,Pliszka et al, 1996,Castellanos, 1997. In animal studies, maternal nicotine exposure produces sexdependent alterations in the development of DA neurochemical markers (Fung, 1988,Fung, 1989,Ribary and Lichtensteiger, 1989,Lichtensteiger and Schlumpf, 1993,Muneoka et al, 1997, and induces hyperactivity in the offspring, which is believed to result from alterations in mesolimbic and nigrostriatal DA systems ,Fung and Lau, 1989,Richardson and Tizabi, 1994,Tizabi et al, 1997,Ajarem and Ahmad, 1998. However, one point of intense controversy is whether the actions of nicotine are mediated directly on DA neurons or are the result of indirect effects such as hypoxia (Slotkin, 1998).…”

Section: Introductionmentioning

confidence: 99%

Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons

2007

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We have combined anatomical and functional methodologies to provide a comprehensive analysis of the properties of nicotinic acetylcholine receptors (nAChRs) on developing dopamine (DA) neurons. Double-labeling in situ hybridization was used to examine the expression of nAChR subunit mRNAs within developing midbrain DA neurons. As brain maturation progressed there was a change in the pattern of subunit mRNA expression within DA neurons, such that α3 and α4 subunits declined and α6 mRNA increased. Although there were strong similarities in subunit mRNA expression in substantia nigra (SNc) and ventral tegmental area (VTA), there was higher expression of α4 mRNA in SNc than VTA at gestational day (G)15, and of α5, α6 and β3 mRNAs during postnatal development. Using a superfusion neurotransmitter release paradigm to functionally characterize nicotine-stimulated release of [ 3 H]DA from striatal slices, the properties of the nAChRs on DA terminals were also found to change with age. Functional nAChRs were detected on striatal terminals at G18. There was a decrease in maximal release in the first postnatal week, followed by an increase in nicotine efficacy and potency during the second and third postnatal weeks. In the transition from adolescence (postnatal days (P) 30 and 40) to adulthood, there was a complex pattern of functional maturation of nAChRs in ventral, but not dorsal, striatum. In males, but not females, there were significant changes in both nicotine potency and efficacy during this developmental period. These findings suggest that nAChRs may play critical functional roles throughout DA neuronal maturation. Keywords adolescent; fetal; nicotine; sex; striatum; maternal smoking Maternal smoking during pregnancy has been correlated with a number of adverse outcomes in the offspring (Lichtensteiger et al., 1988,Lichtensteiger andSchlumpf, 1993), including cognitive deficits that are often manifested in early childhood as attention deficit hyperactivity disorder (ADHD) (Millberger et al., 1996). Though the underlying neurobiological mechanism * Correspondence to: Dr. Layla Azam Department of Biology, University of Utah 257 South 1400 East Salt Lake City, UT 84112 Tel.: (801) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ,Pliszka et al., 1996,Castellanos, 1997. In animal studies, maternal nicotine exposure produces sexdependent alterations in the development of DA neurochemical markers (Fung, 1988,Fung, 1989,Ribary and Lichtensteiger, 1989,Lichtensteiger and Schlumpf, 1993,Muneoka et al., 1997, and induces hyperactivity in the offspring, which is believed...

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Effects of prenatal nicotine exposure on rat striatal dopaminergic and nicotinic systems

Cited by 90 publications

References 29 publications

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Differential Effects of Nicotine and Complex Housing on Subsequent Experience-Dependent Structural Plasticity in the Nucleus Accumbens.

Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons

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