Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood

Peterson, Bradley S.; Rauh, Virginia; Bansal, Ravi; Hao, Xuejun; Toth, Zachary; Nati, Giancarlo; Walsh, Kirwan; Miller, Rachel L.; Arias, Franchesca; Semanek, David; Perera, Frederica P.

doi:10.1001/jamapsychiatry.2015.57

Cited by 297 publications

(220 citation statements)

References 44 publications

(41 reference statements)

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“…People's exposures to PAHs -complex mixtures containing over 100 compounds-are associated Prenatal PAHs exposures are harmful to the developing brain, high levels of PAH-DNA adducts in cord blood have been associated with neural tube defects, and occupational exposures during pregnancy increase the risk for small for gestational age babies [25][26][27]. In the U.S.…”

Section: Cognition Effects and Brain Structural Changesmentioning

confidence: 99%

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Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

et al. 2016

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Air pollution (indoor and outdoor air) is a major issue in public health as epidemiological studies haven pointed to the numerous detrimental health consequences (notably, respiratory and cardiovascular pathology). In the last fifteen years, air pollution has also been considered as a potent environmental risk factor for neurological diseases and neuropathology. In this review, the authors examine the impact of air pollution on children's brain development and its clinical, cognitive, brain structural and metabolic consequences. Long-term potential consequences for adults' brain and effects on multiple sclerosis are also discussed. One challenge is assessing lifetime exposures to outdoor and indoor environments, including occupational exposures: how much, for how long and what type. The diffuse neuroinflammation, the damage to the neurovascular unit, and the production of auto-antibodies to neural and tight junction proteins are worrisome findings in children chronically exposed to concentrations above current standards for ozone and fine particulate matter (PM 2.5 ) and may constitute significant risk factors for the development of Article Outline

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Section: Cognition Effects and Brain Structural Changesmentioning

confidence: 99%

“…Readers also have to be aware that high levels of poverty, low educational attainment, and below average mother's IQ are critical confounder factors to evaluate cognition in children exposed to air pollutants [25].…”

Section: Cognition Effects and Brain Structural Changesmentioning

confidence: 99%

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

et al. 2016

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“…Better air quality reduces infant mortality (Bobak and Leon 1992;Greenstone 2003a, 2003b;Currie and Neidell 2005;Loomis et al 1999) and respiratory problems in both infants and adults (Chauhan and Johnston 2003;Emmanuel 2000;Romieu et al 2002) and can even improve mental health and cognition (Peterson et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Medium- and long-term consequences of pollution on labor supply: evidence from Indonesia

2017

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We use a natural experiment in Indonesia to study the medium-and long-term effects of air pollution on labor supply. We find that exposure to air pollution reduces hours worked and while the medium-term effects are larger in magnitude, some effects do persist in the long term. More interestingly, we are able to provide some insight regarding the underlying channels that contribute to the reduced labor supply. Own health seems to be the only responsible channel in the long term, while in the medium term, a different channel based on dependent caregiving is the most important. JEL Classification: J22, Q53

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“…Since the report, new evidence has become known on the adverse effects of pollution on neurodevelopment. [4][5][6] > Importantly, the toxic health effects of vehicle-related pollution are greater in those socioeconomically deprived, living closer to busy roads, in poor housing, with inadequate diet, accompanying tobacco smoking and in the presence of family stress. > All of these effects are further enhanced by the infl uence of climate change, with atmospheric conditions increasing accumulation of pollutants and formation of ozone and secondary particles.…”

mentioning

confidence: 99%

‘Every breath we take: the lifelong impact of air pollution’ – a call for action

Holgate

2017

Clinical Medicine

106

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Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood

Cited by 297 publications

References 44 publications

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

Medium- and long-term consequences of pollution on labor supply: evidence from Indonesia

‘Every breath we take: the lifelong impact of air pollution’ – a call for action

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