Effects of pre-existing undernutrition on treatment-related complications and treatment outcomes in children with acute lymphoblastic leukemia: A tertiary care center experience

Effect of pre-treatment nutritional status, folate and vitamin B12 levels on induction chemotherapy in children with acute lymphoblastic leukemia

“…The high prevalence (66%) of baseline undernutrition in our patients was comparable to reports from other Indian centres [4,5,17] but was not found to be associated with poor survival in our patients unlike that in the previous reports [4,5], possibly due to different methods of assessment of nutritional status [5]. The association of low serum albumin levels with worse outcome in children with ALL has also been reported by a previous study [18].…”

“…The proportion of undernourished children with ALL varies from nearly 10% in the developed nations [2,3] to more than 60% in the developing countries [4][5][6]. Low folate and B12 levels are common in Indian children [7], and lower levels in children with ALL has been earlier reported [8].…”

Impact of Sociodemographic Factors and Nutrition on the Duration of Induction Phase of Chemotherapy in children with Acute lymphoblastic leukemia: A Tertiary Center Experience from North India

“…Interestingly, both undernutrition and obesity are associated with an inferior event free-survival as reported by Orgel et al [11] A study from India by Roy et al stated that undernourished children experience more episodes of febrile neutropenia resulting in poor outcome. [12,13] Thus, nutritional status of the child at the start of treatment correlates with outcome. In our study, however, the duration of induction was not significantly affected by the nutritional status of the child (P = 0.079).…”

Evaluation of malnutrition as a predictor of adverse outcomes in febrile neutropenia associated with paediatric haematological malignancies

“…suggested poor treatment tolerance and increased complications in patients with malnourishment. In their retrospective cohort study on the effect of undernutrition on treatment outcomes and complications in paediatric ALL, Roy et al . also reported that low values of neutropenia and poor treatment tolerance were related to malnutrition and incidence of febrile neutropenia was also higher in the malnutrition group.…”