2010
DOI: 10.1179/147683010x12611460764769
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Effects of postnatal protein malnutrition on learning and memory procedures

Abstract: Protein malnutrition induces structural, neurochemical and functional changes in the central nervous system leading to alterations in cognitive and behavioral development of rats. The aim of this work was to investigate the effects of postnatal protein malnutrition on learning and memory tasks. Previously malnourished (6% protein) and well-nourished rats (16% protein) were tested in three experiments: working memory tasks in the Morris water maze (Experiment I), recognition memory of objects (Experiment II), a… Show more

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Cited by 39 publications
(43 citation statements)
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References 50 publications
(80 reference statements)
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“…Learning and memory can be assessed at the performance data from the 24 successive trials at the MWM task and the long-lasting reference memory is analyzed according to the 26 th trial data at the Memory Retention Test. Previous studies have also demonstrated that the performance of malnourished rats was impaired compared to control rats both during learning acquisition and memory retention test (Fukuda et al, 2002;Fukuda et al, 2007;Valadares et al, 2010;Zhang et al, 2010) and other studies have presented results related to functional and morphological changes in the hippocampal formation as a consequence of early protein malnutrition (Fukuda et al, 2007;Matos et al, 2011) and protein deprivation in adulthood (Lukoyanov & Andrade, 2000).…”
Section: Discussionmentioning
confidence: 97%
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“…Learning and memory can be assessed at the performance data from the 24 successive trials at the MWM task and the long-lasting reference memory is analyzed according to the 26 th trial data at the Memory Retention Test. Previous studies have also demonstrated that the performance of malnourished rats was impaired compared to control rats both during learning acquisition and memory retention test (Fukuda et al, 2002;Fukuda et al, 2007;Valadares et al, 2010;Zhang et al, 2010) and other studies have presented results related to functional and morphological changes in the hippocampal formation as a consequence of early protein malnutrition (Fukuda et al, 2007;Matos et al, 2011) and protein deprivation in adulthood (Lukoyanov & Andrade, 2000).…”
Section: Discussionmentioning
confidence: 97%
“…Considering several prior studies, it is plausible that the behavioral changes observed may be due to morphological, biochemical and/or functional alterations in the Central Nervous System (Almeida et al, 1996a;Bedi, 1991;Cintra et al, 1990;Galler et al, 1995;Huang et al, 2003;Lukoyanov & Andrade, 2000;Matos et al, 2011;Morgane et al, 1993;Morgane et al, 2002;Zhang et al, 2010), specifi cally on stress response regulation (Camargo, Nascimento, & Almeida, 2008;Françolin-Silva & Almeida, 2004;Rocinholi et al, 1997), observed in prenatal (Almeida, Tonkiss, & Galler, 1996b;Almeida, Tonkiss, & Galler, 1996c;Morgane et al, 1993) and postnatal malnutrition (Almeida et al, 1991;Camargo & Almeida, 2005;Castro, Tracy, & Rudy, 1989;Fukuda et al, 2002;Fukuda et al, 2007;Valadares et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
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“…Vários efeitos da desnutrição precoce sobre o comportamento dos animais na fase adulta já foram documentados em outros estudos (Hernandes, Françolin-Silva, Valadares, Fukuda, & Almeida, 2005;Valadares, Fukuda, Françolin-Silva, Hernandes, & Almeida, 2010). Um desses efeitos é o aumento da motivação por comida ou por água desses animais, quando expostos à privação (Laus, Vales, Costa, & Almeida, 2011).…”
Section: Discussionunclassified
“…Modifications of functionality in nervous system cells due to nutrient deficiency promote changes in the processes involved in learning and memory (Valadares et al 2010). However, this fact is not fully proven because there are studies that indicate improvement in spatial memory in undernourished rodents (Smart et al 1976).…”
mentioning
confidence: 99%