Effects of Polyphenols from Grape Seeds on Renal Lithiasis

Gráses, F.; Prieto, Rafel M.; Fernández-Cabot, Rafel A.; Costa-Bauzà, Antònia; Tur, Fernando; Torres, José

doi:10.1155/2015/813737

Cited by 30 publications

(25 citation statements)

References 38 publications

(38 reference statements)

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“…Initial subepithelial calcification of renal papilla is pre-requisite step in the development of calcium oxalate renal stone. 38 Therefore, elevated renal calcium level in lithiatic control rats indicates calcification of renal papilla and development of calcium oxalate stone in the renal tissue. Furthermore, inhibition of renal calcium level by EA-MBS at specified doses indicates their role in the prevention of calcium oxalate papillary calculus formation.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of ethyl acetate fraction of Biophytum sensitivum extract against sodium oxalate-induced urolithiasis in rats

Pawar

Vyawahare²

2017

Journal of Traditional and Complementary Medicine

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The methanolic whole plant extract of Biophytum sensitivum (感应草gǎnyìng cǎo) has been found to possess antiurolithiatic effect. The present study was undertaken to evaluate the antiurolithiatic effect of some fractions of methanolic whole plant extract of B. sensitivum (MBS) in rats as a step toward activity-directed isolation of antiurolithiatic component. The MBS was successively extracted with dichloromethane, ethyl acetate, ethanol and water to obtain fractions. Sodium oxalate (70 mg/kg, i.p.) was administered to rats for seven days to develop calcium oxalate urolithiasis. These rats were treated with two doses (20 and 40 mg/kg, p.o.) of the fractions, 1 h before sodium oxalate injections. Antiurolithiatic activity was assessed by estimating biochemical changes in urine, serum and kidney homogenate along with histological changes in kidney tissue. Sodium oxalate administration caused biochemical alterations in urine which was found to be prevented significantly by the ethyl acetate fraction. Supplementation with ethyl acetate fraction prevented the elevation of serum creatinine, uric acid and blood urea nitrogen levels. The elevated calcium, oxalate and phosphate levels in the kidney tissue homogenate of lithiatic rats were significantly reduced by the treatment with ethyl acetate fraction. The ethyl acetate fraction also caused significant decrease in lipid peroxidation activity, accumulation of calcium oxalate deposits and histological changes in the kidney tissue. The results showed that the antiurolithiatic component of the methanolic whole plant extract of the plant is contained in the ethyl acetate fraction. The effect is attributed to its diuretic, antioxidant, nephroprotective properties and effect on lowering the concentration of urinary stone-forming constituents.

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Section: Discussionmentioning

confidence: 99%

Protective effect of ethyl acetate fraction of Biophytum sensitivum extract against sodium oxalate-induced urolithiasis in rats

Pawar

Vyawahare²

2017

Journal of Traditional and Complementary Medicine

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“…In COM-treated NRK-52E renal proximal tubular cell line, catechins reestablished the proteolysis of caspase 3 and mitochondrial membrane potential because of its increased SOD activity [72]. This elevated SOD activity of catechins successfully produced inhibitory effects on the renal papillary calcification and enhancement of COM papillary calculi [70][71][72][73]. 8-Hydroxy-20-deoxyguanosine (8-OHdG), OPN and MDA activity was also regulated by catechins in the ethylene glycolinduced rat model of nephrolithiasis [72].…”

Section: Phyto-molecules In the Inhibition Of Kidney Stone Formationmentioning

confidence: 99%

“…Decreases mitochondrial membrane potential (MMP), Caspase-3 activity, renal calcium crystallization,.renal papillary calcification, calcium oxalate monohydrate and papillary calculus formation. [8,72,73] Epigallocatechin-3-gallate (EGCG) Reduces free-radical production, crystal binding capability, urinary oxalate excretion, activities of urinary gammaglutamyl transpeptidase and N-acetylglucosaminidase and α-enolase expression. [8,74] Diosmin Reduces capillary hyper-permeability and glomeruli and tubules degeneration, Diameter of the capillaries and vessels in the cortex is restored.…”

Section: Phyto-molecule Mechanism Of Action Referencementioning

confidence: 99%

Phyto-molecules for Kidney Stones Treatment and Management

Gupta¹,

Kanwar²

2018

Biochem Anal Biochem

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It has been centuries since humans are being affected by kidney stones or urolithiasis. In the past decade, in rural and the urban sectors, kidney stone cases are rising at an alarming rate having a high relapse rate. The rate and prevalence of urolithiasis has been attributed to a number of factors such as age, fluid intake, infections of the urinary tract, climatic conditions sex, genetic predisposition, ethnicity as well as diet. Kidney stones may cause extreme pain and blockage of urine flow, urinary tract infection, hydronephrosis and severe bleeding which necessitates the use of surgery in some cases to remove or break the stones. Although a number of treatments for kidney stones are available which include extracorporeal shock wave lithotripsy (ESWL) and drug therapy but the expensive nature of these therapies and the severe side effects caused by exposure to these shock waves such as acute renal injury, decreased renal function and increased stone recurrence limit their use. As proposed by several in vivo and in vitro studies and clinical trials, using phyto-molecules in the treatment and management of kidney stones has emerged as a novel option. The following study discuses about the various plants, their chemical constituents involved along with their mechanism of action that can be used for the treatment of kidney stones.

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“…Lots of studies provide evidence of correlation between antioxidant levels and kidney stones. It seems that antioxidant therapy reduced calcium oxalate precipitation and increased urinary oxalate excretion in patients with kidney stones (Davalos, Konno, Eshghi, & Choudhury, 2010;Grases et al, 2015;Selvam, 2002). Moreover, free radical scavengers like phenolic compounds provide protection against the deposition of stone (Ghalayini, Al-Ghazo, & Harfeil, 2011).…”

Section: Antioxidative Activity and Fcr Assaymentioning

confidence: 99%

Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double‐blind, placebo‐controlled, clinical trial

Movaghati

Yousefi

Saghebi³

et al. 2019

Phytotherapy Research

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Preclinical studies have shown beneficial effects of black seed (Nigella sativa L.) in the prevention and treatment of renal stones. Hence, we designed a study to evaluate the renal‐stone‐dissolving efficacy of black seed. Sixty patients with renal stones were randomly enrolled in two arms of a randomized, triple‐blind, placebo‐controlled, clinical trial. The patients were treated by black seed capsules (500 mg) or placebo two times per day for 10 weeks. Patients were assessed in terms of size of renal stones by using sonography before and after intervention. In the black seed group, 44.4% of patients excreted their stones completely, and the size of the stones remained unchanged and decreased in 3.7% and 51.8% of patients, respectively. In contrast, in the placebo group, 15.3% of the patients excreted their stones completely, 11.5% had reduction in stone size, 15.3% had increase in stone size, and 57.6% had no change in their stone size. The difference in the mean size of renal stones after the study was significant between the two groups (p < 0.05). N. sativa L., as compared with placebo, is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.

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Effects of Polyphenols from Grape Seeds on Renal Lithiasis

Cited by 30 publications

References 38 publications

Protective effect of ethyl acetate fraction of Biophytum sensitivum extract against sodium oxalate-induced urolithiasis in rats

Protective effect of ethyl acetate fraction of Biophytum sensitivum extract against sodium oxalate-induced urolithiasis in rats

Phyto-molecules for Kidney Stones Treatment and Management

Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double‐blind, placebo‐controlled, clinical trial

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