Effects of polyphenol compounds fromAlchemilla vulgaris on morphofunctional state of thyroid gland in rats exposed to low temperature

Abstract

In control rats and animals receiving polyphenol compounds extracted from Alchemilla vulgaris, intense cooling stimulated synthesis of thyroid hormones and promoted their peripheral deiodination. In control rats, the period of recovery after cooling (readaptation period) was characterized by a compensatory reduction in thyroid function. In rats receiving test preparation, this period was characterized by significant activation of thyroid hormone synthesis and by further growth of reserve follicles that appeared during the cooling. Key Words: polyphenol compounds; thyroid gland," morphometry; thyroid hormones; coolingNegative anthropogenic factors of modern life reduce individual and population health capacities, increase the incidence of specific pathology, and contribute to the development of new diseases caused by ecological stress [ 1 ]. Treatment with plant preparations is one of the most efficient ways of increasing body resistance [4][5][6][7]9]. Active components of many phytopreparations are represented by polyphenol compounds (PPC), characterized by a wide spectrum of biological activities and low toxicity [2]. Neurohumoral mechanisms and, in particular the effects of thyroid hormones play an important role in increasing the body resistance to nonspecific stress factors [5].In this study we investigated the effects of PPC extracted from the overground part ofAlchemilla vulgaris on the functional activity of the thyroid gland in rats exposed to extreme cooling. MATERIALS AND METHODSThe PPC preparation from the overground part of Alchemilla vulgaris was prepared in the

Weight Loss in Animals and Humans Treated with “Weighlevel”, a Combination of Four Medicinal Plants Used in Traditional Arabic and Islamic Medicine

“…This system is generally accepted as a model for fat depletion (fat burning). The amines of A. vulgaris L. are mainly the tannins reported to increase the metabolic rate in cold environments [ 11 ] and the flavonoids are reported to regulate digestive enzymes and to have cardioprotective effects [ 29 ]. Besides metabolic stimulation [ 12 ], olive leaf extracts were shown to inhibit intestinal glucose absorption, and a hypoglycemic effect was reported together with hypotensive and hypolipidemic properties [ 30 – 32 ].…”

“…Olive leaves are a typical herbal remedy of the Mediterranean area and reported to possess hypoglycemic, hypotensive-diuretic and antioxidant properties [ 7 , 10 ]. Extracts from both of these plant leaves have been shown to increase the basal metabolic rate [ 11 , 12 ]. For centuries, mint as well as cumin has been used to reduce appetite [ 8 ] to improve digestion by relieving digestive symptoms such as pain, spasm, gas and dyspepsia and creating a sensation of fullness [ 13 ].…”

Lady's mantle (Alchemilla vulgaris L., Rosaceae): A review of traditional uses, phytochemical profile, and biological properties

“…According to an in vivo study, the extract prepared from the aerial part of lady's mantle and containing polyphenolic compounds was found to stimulate synthesis and peripheral deiodination of thyroid hormones in rats which were subjected to intense cooling. (Borodin et al, 1999;Pawlaczyk et al, 2009). Lady's mantle was reported to possess inhibitory activity of pancreatic lipase, as well, shown in the study of Slanc et al (2009).…”

The genus Alchemilla L. (Rosaceae) in the Altai State Nature Reserve and contiguous areas

“…Тем не менее, данные об их видовом составе можно использовать для выявления актуальных флорогенетических тенденций (Chkalov, Zolotukhin, 2018). Кроме того, манжетки являются ценным лекарственным сырьем (Schimmer, Escheibach, 1997;Borodin et al, 1999;Shrivastava, John, 2006;Ergene et al, 2010;Nikolova et al, 2012;Akkol et al, 2015;Cindrić et al, 2015), что делает изучение их видового состава и межвидовых различий в фармакологических свойствах важной практической задачей (Trendafilova et al, 2012;Akkol et al, 2015).…”